PMID- 32557822
OWN - NLM
STAT- MEDLINE
DCOM- 20201022
LR  - 20201022
IS  - 1540-8191 (Electronic)
IS  - 0886-0440 (Linking)
VI  - 35
IP  - 7
DP  - 2020 Jul
TI  - Over 870 days of successful antibiotic suppression therapy for VRE-infected left 
      ventricular assist device.
PG  - 1746-1748
LID - 10.1111/jocs.14690 [doi]
AB  - Left ventricular assist devices (LVADs) are used in patients with advanced heart 
      failure. Infections are common complications following device placement; however, 
      the efficacy of chronic antimicrobial suppression therapy for deep-seated 
      infections is not well characterized. We report the case of a 49-year-old male 
      with a HeartMate II LVAD who presented with a methicillin-sensitive 
      Staphylococcus aureus pump pocket infection that was subsequently treated with 
      antibiotics and HeartMate III pump exchange. A vancomycin-resistant Enterococcus 
      faecium (VRE) pump pocket infection then developed and responded to surgical 
      drainage followed by long-term suppression with daptomycin then linezolid for 
      over 870 days. A second pump exchange was not required. To our knowledge, this 
      represents the longest reported use of daptomycin (341 days) without symptomatic 
      adverse events. Managing infections caused by multidrug-resistant pathogens 
      presents a clinical challenge. This case demonstrates the potential for 
      antimicrobial suppression therapy to allow for successful retention of a 
      VRE-infected LVAD.
CI  - (c) 2020 Wiley Periodicals LLC.
FAU - Radcliffe, Christopher
AU  - Radcliffe C
AUID- ORCID: 0000-0001-8352-1482
AD  - Yale School of Medicine, New Haven, Connecticut.
FAU - Grant, Matthew
AU  - Grant M
AD  - Yale School of Medicine, New Haven, Connecticut.
AD  - Department of Internal Medicine, Section of Infectious Diseases, Yale New Haven 
      Hospital, New Haven, Connecticut.
LA  - eng
PT  - Case Reports
DEP - 20200619
PL  - United States
TA  - J Card Surg
JT  - Journal of cardiac surgery
JID - 8908809
RN  - 0 (Anti-Bacterial Agents)
RN  - ISQ9I6J12J (Linezolid)
RN  - NWQ5N31VKK (Daptomycin)
SB  - IM
MH  - Anti-Bacterial Agents/*administration & dosage
MH  - Daptomycin/*administration & dosage
MH  - Drug Therapy, Combination
MH  - *Enterococcus faecium
MH  - Gram-Positive Bacterial Infections/*drug therapy/etiology/*microbiology
MH  - Heart Ventricles
MH  - Heart-Assist Devices/*adverse effects/*microbiology
MH  - Humans
MH  - Linezolid/*administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Prosthesis Failure/*adverse effects
MH  - Prosthesis-Related Infections/*drug therapy/etiology/*microbiology
MH  - Time Factors
MH  - Treatment Outcome
MH  - Vancomycin Resistance
OTO - NOTNLM
OT  - transplant
EDAT- 2020/06/20 06:00
MHDA- 2020/10/23 06:00
CRDT- 2020/06/20 06:00
PHST- 2020/06/20 06:00 [pubmed]
PHST- 2020/10/23 06:00 [medline]
PHST- 2020/06/20 06:00 [entrez]
AID - 10.1111/jocs.14690 [doi]
PST - ppublish
SO  - J Card Surg. 2020 Jul;35(7):1746-1748. doi: 10.1111/jocs.14690. Epub 2020 Jun 19.