PMID- 32558031
OWN - NLM
STAT- MEDLINE
DCOM- 20210406
LR  - 20230314
IS  - 1552-6569 (Electronic)
IS  - 1051-2284 (Print)
IS  - 1051-2284 (Linking)
VI  - 30
IP  - 5
DP  - 2020 Sep
TI  - Observation of Reduced Homeostatic Metabolic Activity and/or Coupling in White 
      Matter Aging.
PG  - 658-665
LID - 10.1111/jon.12744 [doi]
AB  - BACKGROUND AND PURPOSE: Transvascular water exchange plays a key role in the 
      functional integrity of the blood-brain barrier (BBB). In white matter (WM), a 
      variety of imaging modalities have demonstrated age-related changes in structure 
      and metabolism, but the extent to which water exchange is altered remains 
      unclear. Here, we investigated the cumulative effects of healthy aging on WM 
      capillary water exchange. METHODS: A total of 38 healthy adults (aged 36-80 
      years) were studied using 7T dynamic contrast enhanced MRI. Blood volume fraction 
      (v(b) ) and capillary water efflux rate constant (k(po) ) were determined by 
      fitting changes in the (1) H(2) O longitudinal relaxation rate constant (R(1) ) 
      during contrast agent bolus passage to a two-compartment exchange model. WM 
      volume was determined by morphometric analysis of structural images. RESULTS: 
      R(1) values and WM volume showed similar trajectories of age-related decline. 
      Among all subjects, v(b) and k(po) averaged 1.7 (+/-0.5) mL/100 g of tissue and 2.1 
      (+/-1.1) s(-1) , respectively. While v(b) showed minimal changes over the 
      40-year-age span of participants, k(po) declined 0.06 s(-1) (ca. 3%) per year (r 
      = -.66; P < .0005), from near 4 s(-1) at age 30 to ca. 2 s(-1) at age 70. The 
      association remained significant after controlling for WM volume. CONCLUSIONS: 
      Previous studies have shown that k(po) tracks Na(+) , K(+) -ATPase 
      activity-dependent water exchange at the BBB and likely reflects 
      neurogliovascular unit (NGVU) coupled metabolic activity. The age-related decline 
      in k(po) observed here is consistent with compromised NGVU metabolism in older 
      individuals and the dysregulated cellular bioenergetics that accompany normal 
      brain aging.
CI  - (c) 2020 American Society of Neuroimaging.
FAU - Anderson, Valerie C
AU  - Anderson VC
AUID- ORCID: 0000-0001-5271-9410
AD  - Advanced Imaging Research Center, Oregon Health & Science University, Portland, 
      OR.
FAU - Tagge, Ian J
AU  - Tagge IJ
AD  - Advanced Imaging Research Center, Oregon Health & Science University, Portland, 
      OR.
FAU - Li, Xin
AU  - Li X
AD  - Advanced Imaging Research Center, Oregon Health & Science University, Portland, 
      OR.
FAU - Quinn, Joseph F
AU  - Quinn JF
AD  - Department of Neurology, Oregon Health & Science University, Portland, OR.
FAU - Kaye, Jeffrey A
AU  - Kaye JA
AD  - Department of Neurology, Oregon Health & Science University, Portland, OR.
FAU - Bourdette, Dennis N
AU  - Bourdette DN
AD  - Department of Neurology, Oregon Health & Science University, Portland, OR.
FAU - Spain, Rebecca I
AU  - Spain RI
AD  - Department of Neurology, Oregon Health & Science University, Portland, OR.
FAU - Riccelli, Louis P
AU  - Riccelli LP
AD  - Diagnostic Radiology, Oregon Health & Science University, Portland, OR.
FAU - Sammi, Manoj K
AU  - Sammi MK
AD  - Advanced Imaging Research Center, Oregon Health & Science University, Portland, 
      OR.
FAU - Springer, Charles S Jr
AU  - Springer CS Jr
AD  - Advanced Imaging Research Center, Oregon Health & Science University, Portland, 
      OR.
FAU - Rooney, William D
AU  - Rooney WD
AD  - Advanced Imaging Research Center, Oregon Health & Science University, Portland, 
      OR.
LA  - eng
GR  - K25 AG033638/AG/NIA NIH HHS/United States
GR  - P30 AG066518/AG/NIA NIH HHS/United States
GR  - S10 OD018224/OD/NIH HHS/United States
GR  - R01 EB007258/EB/NIBIB NIH HHS/United States
GR  - P30 AG008017/AG/NIA NIH HHS/United States
GR  - NS089260/NH/NIH HHS/United States
GR  - R01 NS040801/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20200617
PL  - United States
TA  - J Neuroimaging
JT  - Journal of neuroimaging : official journal of the American Society of 
      Neuroimaging
JID - 9102705
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*metabolism
MH  - Blood-Brain Barrier/diagnostic imaging/metabolism
MH  - Brain/*diagnostic imaging/metabolism
MH  - Female
MH  - Homeostasis/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - White Matter/*diagnostic imaging/metabolism
PMC - PMC7529981
MID - NIHMS1615562
OTO - NOTNLM
OT  - Aging
OT  - blood brain barrier, DCE-MRI, water cycling
OT  - white matter
EDAT- 2020/06/20 06:00
MHDA- 2021/04/07 06:00
PMCR- 2021/09/01
CRDT- 2020/06/20 06:00
PHST- 2020/04/13 00:00 [received]
PHST- 2020/06/01 00:00 [revised]
PHST- 2020/06/02 00:00 [accepted]
PHST- 2020/06/20 06:00 [pubmed]
PHST- 2021/04/07 06:00 [medline]
PHST- 2020/06/20 06:00 [entrez]
PHST- 2021/09/01 00:00 [pmc-release]
AID - 10.1111/jon.12744 [doi]
PST - ppublish
SO  - J Neuroimaging. 2020 Sep;30(5):658-665. doi: 10.1111/jon.12744. Epub 2020 Jun 17.