PMID- 32558252
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20230124
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Linking)
VI  - 21
IP  - 1
DP  - 2021 Jan
TI  - Stem cell donor HLA typing improves CPRA in kidney allocation.
PG  - 138-147
LID - 10.1111/ajt.16156 [doi]
AB  - The Organ Procurement and Transplantation Network (OPTN) Kidney Allocation System 
      provides a priority to sensitized candidates based on the calculated panel 
      reactive antibody (CPRA) value. The human leukocyte antigen (HLA) haplotype 
      reference panel used for calculation of the CPRA by the United Network for Organ 
      Sharing (UNOS), the OPTN contractor, has limitations. We derived a novel panel 
      from the National Marrow Donor Program HLA haplotype data set and compared the 
      accuracy of CPRA values generated with this panel (NMDP-CPRA) to those generated 
      from the UNOS panel (UNOS-CPRA), using predicted and actual deceased donor kidney 
      offers for a cohort of 24 282 candidates. The overall accuracy for kidney offers 
      was similar using NMDP-CPRA and UNOS-CPRA. Accuracy was slightly higher for 
      NMDP-CPRA than UNOS-CPRA for candidates in several highly sensitized CPRA 
      categories, with deviations in linkage disequilibrium for Caucasians and the 
      smaller size of the UNOS panel as contributing factors. HLA data derived from 
      stem cell donors yields CPRA values that are comparable to those derived from 
      deceased kidney donors while improving upon several problems with the current 
      reference panel. Consideration should be given to using stem cell donors as the 
      reference panel for calculation of CPRA to improve equity in kidney transplant 
      allocation.
CI  - (c) 2020 The American Society of Transplantation and the American Society of 
      Transplant Surgeons.
FAU - Kransdorf, Evan P
AU  - Kransdorf EP
AUID- ORCID: 0000-0002-0507-2412
AD  - Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, California, USA.
FAU - Pando, Marcelo J
AU  - Pando MJ
AD  - Transplant Immunology Laboratory, Scott & White Medical Center, Temple, Texas, 
      USA.
FAU - Stewart, Darren
AU  - Stewart D
AUID- ORCID: 0000-0002-6764-4842
AD  - Research Department, United Network for Organ Sharing, Richmond, Virginia, USA.
FAU - Lindblad, Kelsi
AU  - Lindblad K
AD  - Research Department, United Network for Organ Sharing, Richmond, Virginia, USA.
FAU - Bray, Robert
AU  - Bray R
AD  - HLA Laboratory, Emory University Medical Center, Atlanta, Georgia, USA.
FAU - Murphey, Cathi
AU  - Murphey C
AD  - HLA Laboratory, Southwest Immunodiagnostics, San Antonio, Texas, USA.
FAU - Kaur, Navchetan
AU  - Kaur N
AD  - Department of Pathology, Tulane University School of Medicine, New Orleans, 
      Louisiana, USA.
FAU - Patel, Jignesh K
AU  - Patel JK
AD  - Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, California, USA.
FAU - Kim, Irene
AU  - Kim I
AD  - Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, 
      California, USA.
FAU - Zhang, Xiaohai
AU  - Zhang X
AUID- ORCID: 0000-0002-7188-7855
AD  - Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, 
      California, USA.
FAU - Maiers, Martin
AU  - Maiers M
AD  - National Marrow Donor Program, Minneapolis, Minnesota, USA.
FAU - Kobashigawa, Jon A
AU  - Kobashigawa JA
AD  - Cedars-Sinai Medical Center, Smidt Heart Institute, Los Angeles, California, USA.
AD  - Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, 
      California, USA.
FAU - Gragert, Loren
AU  - Gragert L
AUID- ORCID: 0000-0002-5945-6518
AD  - Department of Pathology, Tulane University School of Medicine, New Orleans, 
      Louisiana, USA.
AD  - National Marrow Donor Program, Minneapolis, Minnesota, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200713
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (HLA Antigens)
RN  - 0 (Isoantibodies)
SB  - IM
MH  - HLA Antigens
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Isoantibodies
MH  - Kidney
MH  - Stem Cells
MH  - Tissue Donors
MH  - *Tissue and Organ Procurement
OTO - NOTNLM
OT  - Organ Procurement and Transplantation Network (OPTN)
OT  - United Network for Organ Sharing (UNOS)
OT  - clinical research/practice
OT  - health services and outcomes research
OT  - histocompatibility
OT  - kidney transplantation/nephrology
OT  - organ allocation
OT  - organ procurement and allocation
OT  - panel reactive antibody (PRA)
OT  - sensitization
EDAT- 2020/06/20 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/06/20 06:00
PHST- 2020/04/08 00:00 [received]
PHST- 2020/05/19 00:00 [revised]
PHST- 2020/06/13 00:00 [accepted]
PHST- 2020/06/20 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/06/20 06:00 [entrez]
AID - S1600-6135(22)08324-1 [pii]
AID - 10.1111/ajt.16156 [doi]
PST - ppublish
SO  - Am J Transplant. 2021 Jan;21(1):138-147. doi: 10.1111/ajt.16156. Epub 2020 Jul 
      13.