PMID- 32558632
OWN - NLM
STAT- MEDLINE
DCOM- 20210712
LR  - 20210712
IS  - 1476-8305 (Electronic)
IS  - 1028-415X (Linking)
VI  - 23
IP  - 10
DP  - 2020 Oct
TI  - The interaction between dietary Non-Enzymatic Antioxidant Capacity (NEAC) with 
      variants of Melanocortin-4 receptor (MC4R) 18q21.23-rs17782313 locus on 
      hypothalamic hormones and cardio-metabolic risk factors in obese individuals from 
      Iran.
PG  - 824-837
LID - 10.1080/1028415X.2020.1780738 [doi]
AB  - Background: In the current study, we aimed to evaluate the interaction between 
      dietary Non-Enzymatic Antioxidant Capacity (NEAC) and rs17782313 polymorphism on 
      hypothalamic hormones and cardio-metabolic risk factors. Methods: A total of 287 
      subjects (aged 20-50 years, 147 males and 140 females) enrolled in the 
      cross-sectional study. Dietary NEAC was assessed using databases of NEAC 
      measurements compiled from outcomes for three different analyses: oxygen radical 
      absorbance capacity (ORAC), ferric reducing-antioxidant power (FRAP), and total 
      radical-trapping antioxidant parameter (TRAP) and genotyping for the near MC4R 
      rs17782313 was carried out by Polymerase chain reaction-restriction fragments 
      length polymorphism (PCR-RFLP) method. Results: The significant interactions were 
      found between adherence to the dietary NEAC and MC4R rs17782313 in relation to 
      high-density lipoprotein-cholesterol (HDL-C), glucose, alpha-melanocyte stimulating 
      hormone (alpha-MSH), insulin and quantitative insulin sensitivity check index 
      (QUICKI) (P (Interaction) = 0.03, 0.01, 0.04, 0.04 and 0.04, respectively). In 
      homozygous subjects for the minor allele, the serum insulin level and QUICKI in 
      participants with the highest adherence to TRAP were significantly higher than 
      those with the lowest adherence (p < 0.001). There was a significant inverse 
      association between high ORAC score and risk of metabolic syndrome even after 
      adjusting for potential confounders (OR: 0.33; 95%CI:0.13-0.81) and also a 
      significant inverse association between high NEAC (ORAC, FRAP and TRAP assays) 
      score and high triglyceride (TG) level was found in obese adults. Conclusion: In 
      conclusion, our study found for the first time that the NEAC significantly 
      interacts with the rs17782313 genotypes to influence several metabolic risk 
      factors in obesity.
FAU - Mohammadi, Mohaddeseh
AU  - Mohammadi M
AD  - Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Khodarahmi, Mahdieh
AU  - Khodarahmi M
AD  - Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Kahroba, Houman
AU  - Kahroba H
AD  - Molecular Medicine Research Center, Tabriz University of Medical Sciences, 
      Tabriz, Iran.
FAU - Farhangi, Mahdieh Abbasalizad
AU  - Farhangi MA
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
FAU - Vajdi, Mahdi
AU  - Vajdi M
AD  - Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20200619
PL  - England
TA  - Nutr Neurosci
JT  - Nutritional neuroscience
JID - 100892202
RN  - 0 (Hypothalamic Hormones)
RN  - 0 (MC4R protein, human)
RN  - 0 (Receptor, Melanocortin, Type 4)
SB  - IM
MH  - Adult
MH  - *Cardiometabolic Risk Factors
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Hypothalamic Hormones/genetics/*metabolism
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Obesity/epidemiology/genetics/*metabolism
MH  - *Oxygen Radical Absorbance Capacity
MH  - Polymorphism, Single Nucleotide
MH  - Receptor, Melanocortin, Type 4/*genetics/*metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Melanocortin-4 receptor‌
OT  - Obesity
OT  - TAC
OT  - antioxidants
OT  - gene-diet interaction
OT  - metabolic factors
OT  - oxidative stress
OT  - polymorphism
EDAT- 2020/06/20 06:00
MHDA- 2021/07/13 06:00
CRDT- 2020/06/20 06:00
PHST- 2020/06/20 06:00 [pubmed]
PHST- 2021/07/13 06:00 [medline]
PHST- 2020/06/20 06:00 [entrez]
AID - 10.1080/1028415X.2020.1780738 [doi]
PST - ppublish
SO  - Nutr Neurosci. 2020 Oct;23(10):824-837. doi: 10.1080/1028415X.2020.1780738. Epub 
      2020 Jun 19.