PMID- 32559636
OWN - NLM
STAT- MEDLINE
DCOM- 20210603
LR  - 20210603
IS  - 1618-131X (Electronic)
IS  - 1438-4639 (Linking)
VI  - 229
DP  - 2020 Aug
TI  - Association between pre/perinatal exposure to POPs and children's anogenital 
      distance at age 4 years: A study from the INMA-Asturias cohort.
PG  - 113563
LID - S1438-4639(20)30509-5 [pii]
LID - 10.1016/j.ijheh.2020.113563 [doi]
AB  - BACKGROUND: Prenatal exposure to endocrine-disrupting chemicals may impair 
      genital development and alter reproductive tract anatomy. Anogenital distance 
      (AGD) is a useful biomarker of exposure to chemicals that act as endocrine 
      disruptors. We evaluated associations between prenatal and perinatal exposure to 
      several persistent organic pollutants (POPs) and AGD in 4-year-old children. 
      METHODS: Data were drawn from the INMA-Asturias cohort. Pediatricians measured 
      the anofourchetal distance in female children and anoscrotal distance in male 
      children. The anogenital index (AGI) was defined as the AGD divided by the 
      child's weight at age of examination. We measured the levels of two 
      hexachlorocyclohexane isomers, hexachlorobenzene, dichlorodiphenyltrichloroethane 
      (DDT) and its metabolites, six polychlorinated biphenyl (PCB) congeners, and six 
      polybrominated diphenyl ether (PBDE) congeners in maternal serum at 12 
      gestational weeks (n = 155) and in cord blood serum (n = 229). Anthropometric and 
      parental sociodemographic variables were collected via face-to-face interviews. 
      Linear regression models were used to evaluate the relationship between exposure 
      to POPs and AGI, adjusted for confounders and stratified by sex. RESULTS: In male 
      children, we found inverse associations between AGI and maternal concentrations 
      of PCB-138 (ss = -0.041, 95% confidence interval [CI]: -0.074, -0.008, second 
      tertile), PCB-153 (ss = -0.052, 95% CI: -0.085, -0.020, second tertile), PCB-180 
      ss = -0.065, 95% CI: -0.096, -0.035, second tertile; ss = -0.042, 95% CI: -0.073, 
      -0.011, third tertile), PBDE-209 (ss = -0.031, 95% CI: -0.058, -0.006), cord serum 
      concentrations of PCB-153 (ss = -0.029, 95% CI: -0.059, -0.000, second tertile; 
      ss = -0.047, 95% CI: -0.085, -0.008, third tertile), and PCB-180 (ss = -0.041, 95% 
      CI: -0.078, -0.005, third tertile). In female children, AGI was positively 
      associated with maternal serum concentrations of PCB-101 (ss = 0.039, 95% CI: 
      0.002, 0.076, second tertile), and higher cord serum levels of 4,4'-DDT 
      (ss = 0.032, 95% CI: 0.003, 0.061, third tertile) and 4,4'-DDE (ss = 0.040, 95% CI: 
      0.011, 0.069, third tertile). CONCLUSIONS: Our findings provide evidence of 
      associations between specific POPs and AGI in boys and girls aged 4 years, and 
      suggest that pre/perinatal exposure to POPs has a feminizing effect in males and 
      a masculinizing effect in females.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier GmbH.. All rights reserved.
FAU - Garcia-Villarino, Miguel
AU  - Garcia-Villarino M
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Unit of Molecular Cancer 
      Epidemiology, University Institute of Oncology of the Principality of Asturias 
      (IUOPA), Department of Medicine, University of Oviedo, Julian Claveria Street 
      s/n, 33006, Oviedo, Asturias, Spain; Instituto de Investigacion Sanitaria del 
      Principado de Asturias (ISPA), Roma Avenue s/n. 33001, Oviedo, Asturias, Spain. 
      Electronic address: miguelvillarino@outlook.es.
FAU - Riano-Galan, Isolina
AU  - Riano-Galan I
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Instituto de Investigacion 
      Sanitaria del Principado de Asturias (ISPA), Roma Avenue s/n. 33001, Oviedo, 
      Asturias, Spain; Servicio de Pediatria, Endocrinologia, HUCA, Roma Avenue s/n. 
      33001, Oviedo, Asturias, Spain.
FAU - Rodriguez-Dehli, Ana Cristina
AU  - Rodriguez-Dehli AC
AD  - Instituto de Investigacion Sanitaria del Principado de Asturias (ISPA), Roma 
      Avenue s/n. 33001, Oviedo, Asturias, Spain; Servicio de Pediatria. Hospital San 
      Agustin, Heros Street, 4, 33410, Aviles, Asturias, Spain.
FAU - Freire, Carmen
AU  - Freire C
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Instituto de Investigacion 
      Biosanitaria de Granada (ibs.Granada), Avenida de Madrid 15, 18010, Granada, 
      Spain.
FAU - Vizcaino, Esther
AU  - Vizcaino E
AD  - Department of environmental Chemistry, Institute of Environmental Assessment and 
      Water Research (IDAEA-CSIC), Jordi Girona Street, 18-26, 08034, Barcelona, 
      Cataluna, Spain.
FAU - Grimalt, Joan O
AU  - Grimalt JO
AD  - Department of environmental Chemistry, Institute of Environmental Assessment and 
      Water Research (IDAEA-CSIC), Jordi Girona Street, 18-26, 08034, Barcelona, 
      Cataluna, Spain.
FAU - Tardon, Adonina
AU  - Tardon A
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Unit of Molecular Cancer 
      Epidemiology, University Institute of Oncology of the Principality of Asturias 
      (IUOPA), Department of Medicine, University of Oviedo, Julian Claveria Street 
      s/n, 33006, Oviedo, Asturias, Spain; Instituto de Investigacion Sanitaria del 
      Principado de Asturias (ISPA), Roma Avenue s/n. 33001, Oviedo, Asturias, Spain.
FAU - Fernandez-Somoano, Ana
AU  - Fernandez-Somoano A
AD  - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), 
      Monforte de Lemos Avenue, 3-5, 28029, Madrid, Spain; Unit of Molecular Cancer 
      Epidemiology, University Institute of Oncology of the Principality of Asturias 
      (IUOPA), Department of Medicine, University of Oviedo, Julian Claveria Street 
      s/n, 33006, Oviedo, Asturias, Spain; Instituto de Investigacion Sanitaria del 
      Principado de Asturias (ISPA), Roma Avenue s/n. 33001, Oviedo, Asturias, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200616
PL  - Germany
TA  - Int J Hyg Environ Health
JT  - International journal of hygiene and environmental health
JID - 100898843
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
SB  - IM
MH  - Adult
MH  - Anal Canal/*anatomy & histology
MH  - Anthropometry
MH  - Biological Monitoring
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Endocrine Disruptors/*blood
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Genitalia/*anatomy & histology
MH  - Halogenated Diphenyl Ethers/*blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*blood
MH  - Infant, Newborn
MH  - Male
MH  - Maternal Exposure
MH  - Maternal-Fetal Exchange
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Spain
OTO - NOTNLM
OT  - Anogenital distance
OT  - Anogenital index
OT  - Endocrine disruptor
OT  - Genital development
OT  - Persistent organic pollutant
EDAT- 2020/06/20 06:00
MHDA- 2021/06/04 06:00
CRDT- 2020/06/20 06:00
PHST- 2019/10/20 00:00 [received]
PHST- 2020/05/08 00:00 [revised]
PHST- 2020/05/18 00:00 [accepted]
PHST- 2020/06/20 06:00 [pubmed]
PHST- 2021/06/04 06:00 [medline]
PHST- 2020/06/20 06:00 [entrez]
AID - S1438-4639(20)30509-5 [pii]
AID - 10.1016/j.ijheh.2020.113563 [doi]
PST - ppublish
SO  - Int J Hyg Environ Health. 2020 Aug;229:113563. doi: 10.1016/j.ijheh.2020.113563. 
      Epub 2020 Jun 16.