PMID- 32561475
OWN - NLM
STAT- MEDLINE
DCOM- 20210223
LR  - 20210223
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Linking)
VI  - 219
DP  - 2020 Oct 1
TI  - Neural correlates of self- and other-referential processing in young adolescents 
      and the effects of testosterone and peer similarity.
PG  - 117060
LID - S1053-8119(20)30546-2 [pii]
LID - 10.1016/j.neuroimage.2020.117060 [doi]
AB  - During adolescence, self-concept develops profoundly, accompanied by major 
      changes in hormone levels. Self-evaluations become more complex, and peers and 
      their opinions increasingly salient. Neuroimaging studies have investigated self- 
      and other-related processing in adolescents, however, the influence of similarity 
      of peers on these processes is still unclear, as well as functional connectivity 
      underlying such processes. We investigated the effect of peer similarity on 
      neural activity and connectivity underlying self- and other-referential 
      processing, by distinguishing between a similar and dissimilar peer when making 
      other-evaluations. Moreover, we explored the association between testosterone and 
      brain activity during self-evaluations. Sixty-six young adolescents underwent 
      functional MRI while performing a trait judgement task in which they indicated 
      whether an adjective described themselves, a similar or a dissimilar classmate. 
      The ventral medial prefrontal cortex (MPFC) showed increased engagement in 
      self-referential processing, and the posterior cingulate cortex and right 
      temporal parietal junction during other-evaluations. However, activity did not 
      differ between the similar and dissimilar other conditions. Functional 
      connectivity of the ventral MPFC included the striatum when evaluating the 
      similar peer and frontoparietal regions when evaluating the dissimilar peer. 
      Furthermore, inter-individual differences in testosterone levels were positively 
      associated with dorsal MPFC activity in males. This study provides insight into 
      the influence of peer similarity on activity and connectivity underlying 
      other-referential processing in young adolescents, and suggests that testosterone 
      affects neural correlates of self-referential processing.
CI  - Copyright (c) 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - van Buuren, Mariet
AU  - van Buuren M
AD  - Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral 
      and Movement Sciences, Institute for Brain and Behavior Amsterdam, Vrije 
      Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT, Amsterdam, the 
      Netherlands. Electronic address: m.van.buuren@vu.nl.
FAU - Walsh, Reubs J
AU  - Walsh RJ
AD  - Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral 
      and Movement Sciences, Institute for Brain and Behavior Amsterdam, Vrije 
      Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT, Amsterdam, the 
      Netherlands.
FAU - Sijtsma, Hester
AU  - Sijtsma H
AD  - Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral 
      and Movement Sciences, Institute for Brain and Behavior Amsterdam, Vrije 
      Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT, Amsterdam, the 
      Netherlands.
FAU - Hollarek, Miriam
AU  - Hollarek M
AD  - Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral 
      and Movement Sciences, Institute for Brain and Behavior Amsterdam, Vrije 
      Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT, Amsterdam, the 
      Netherlands.
FAU - Lee, Nikki C
AU  - Lee NC
AD  - Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral 
      and Movement Sciences, Institute for Brain and Behavior Amsterdam, Vrije 
      Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT, Amsterdam, the 
      Netherlands.
FAU - Bos, Peter A
AU  - Bos PA
AD  - Institute of Education and Child Studies, Faculty of Social and Behavioral 
      Sciences, Leiden University, Wassenaarseweg 52, 2333, AK, Leiden, the 
      Netherlands.
FAU - Krabbendam, Lydia
AU  - Krabbendam L
AD  - Department of Clinical, Neuro and Developmental Psychology, Faculty of Behavioral 
      and Movement Sciences, Institute for Brain and Behavior Amsterdam, Vrije 
      Universiteit Amsterdam, Van der Boechorststraat 7, 1081, BT, Amsterdam, the 
      Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200616
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Adolescent
MH  - Brain/*diagnostic imaging
MH  - Brain Mapping
MH  - Child
MH  - Emotions/physiology
MH  - Female
MH  - Humans
MH  - Judgment/*physiology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Peer Group
MH  - Saliva/chemistry
MH  - *Self Concept
MH  - *Social Perception
MH  - Testosterone/*analysis
OTO - NOTNLM
OT  - Adolescence
OT  - Medial prefrontal cortex
OT  - Peer similarity
OT  - Self
OT  - Testosterone
OT  - fMRI
COIS- Declaration of competing interest None.
EDAT- 2020/06/21 06:00
MHDA- 2021/02/24 06:00
CRDT- 2020/06/21 06:00
PHST- 2020/01/06 00:00 [received]
PHST- 2020/05/24 00:00 [revised]
PHST- 2020/06/12 00:00 [accepted]
PHST- 2020/06/21 06:00 [pubmed]
PHST- 2021/02/24 06:00 [medline]
PHST- 2020/06/21 06:00 [entrez]
AID - S1053-8119(20)30546-2 [pii]
AID - 10.1016/j.neuroimage.2020.117060 [doi]
PST - ppublish
SO  - Neuroimage. 2020 Oct 1;219:117060. doi: 10.1016/j.neuroimage.2020.117060. Epub 
      2020 Jun 16.