PMID- 32562169
OWN - NLM
STAT- MEDLINE
DCOM- 20211129
LR  - 20221207
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 25
IP  - 1
DP  - 2021 Mar
TI  - Relationship between obstructive sleep apnoea during rapid eye movement sleep and 
      metabolic syndrome parameters in patients with type 2 diabetes mellitus.
PG  - 309-314
LID - 10.1007/s11325-020-02129-7 [doi]
AB  - PURPOSE: Sleep-disordered breathing (SDB) is associated with hypertension, poor 
      glycemic control and dyslipidemia. Usually, apnoea events tend to be more 
      prominent during rapid eye movement (REM) sleep than non-REM (NREM) sleep. We 
      examined which SDB parameters are associated with blood pressure (BP), HbA1c and 
      lipid profile in patients with type 2 diabetes (T2D). METHODS: A total of 185 
      patients with T2D who underwent polysomnography were analysed. Exclusion criteria 
      were: the presence of pulmonary diseases, central sleep apnoea, treated SDB, or 
      REM sleep < 30 min. To predict BP, HbA1c, and lipid profiles, we performed 
      multiple linear regression analyses adjusted for known risk factors. 
      Subsequently, we performed multivariable logistic regression analyses. RESULTS: 
      Patient characteristics (mean +/- standard deviation/median) were as follows: age 
      58.0 +/- 11.8 years, body mass index 26.0 kg/m2 (24.1-28.9 kg/m2 ), systolic BP 134 
      +/- 19 mmHg, mean BP 98 +/- 14 mmHg, HbA1c 7.4% (6.8-8.4%), triglyceride 143 mg/dL 
      (97-195 mg/dL), non-high density lipoprotein (non-HDL) cholesterol 143 mg/dL 
      (120-163 mg/dL), REM-apnoea-hypopnea index (AHI) 35.1/h (21.1-53.1/h). The 
      analyses revealed that REM-AHI was independently associated with systolic and 
      mean BP, whereas NREM-AHI was not. A statistically significant association was 
      not observed between REM-AHI and HbA1c or lipid profile. CONCLUSION: In patients 
      with T2D, REM-AHI was associated with systolic and mean BP. The alteration of BP, 
      associated with SDB during REM sleep, may be an important pathophysiological link 
      between SDB and cardiovascular diseases.
FAU - Uchida, Takayasu
AU  - Uchida T
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, 2-2-2 Toranomon, 
      Minato-ku, Tokyo, 105-8470, Japan.
FAU - Nishimura, Akihiro
AU  - Nishimura A
AUID- ORCID: 0000-0002-9347-1228
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, 2-2-2 Toranomon, 
      Minato-ku, Tokyo, 105-8470, Japan. toranishi@gmail.com.
FAU - Kasai, Takatoshi
AU  - Kasai T
AD  - Sleep Center, Toranomon Hospital, Tokyo, Japan.
AD  - Department of Cardiovascular Medicine, Cardiovascular Respiratory Sleep Medicine, 
      Juntendo University, Tokyo, Japan.
FAU - Kikuno, Shota
AU  - Kikuno S
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, 2-2-2 Toranomon, 
      Minato-ku, Tokyo, 105-8470, Japan.
FAU - Nagasawa, Kaoru
AU  - Nagasawa K
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, 2-2-2 Toranomon, 
      Minato-ku, Tokyo, 105-8470, Japan.
FAU - Okubo, Minoru
AU  - Okubo M
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, 2-2-2 Toranomon, 
      Minato-ku, Tokyo, 105-8470, Japan.
FAU - Narui, Koji
AU  - Narui K
AD  - Sleep Center, Toranomon Hospital, Tokyo, Japan.
FAU - Mori, Yasumichi
AU  - Mori Y
AD  - Department of Endocrinology and Metabolism, Toranomon Hospital, 2-2-2 Toranomon, 
      Minato-ku, Tokyo, 105-8470, Japan.
LA  - eng
PT  - Journal Article
DEP - 20200619
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Lipoproteins)
RN  - 0 (Triglycerides)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Pressure/*physiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Glycated Hemoglobin
MH  - Humans
MH  - Lipoproteins/blood
MH  - Male
MH  - Metabolic Syndrome/*blood
MH  - Middle Aged
MH  - Polysomnography
MH  - Severity of Illness Index
MH  - Sleep Apnea, Obstructive/*physiopathology
MH  - Sleep, REM/*physiology
MH  - Triglycerides/blood
OTO - NOTNLM
OT  - Diabetes mellitus, type 2
OT  - Hypertension
OT  - Sleep apnoea syndromes
OT  - Sleep, REM
EDAT- 2020/06/21 06:00
MHDA- 2021/11/30 06:00
CRDT- 2020/06/21 06:00
PHST- 2020/02/14 00:00 [received]
PHST- 2020/06/13 00:00 [accepted]
PHST- 2020/06/04 00:00 [revised]
PHST- 2020/06/21 06:00 [pubmed]
PHST- 2021/11/30 06:00 [medline]
PHST- 2020/06/21 06:00 [entrez]
AID - 10.1007/s11325-020-02129-7 [pii]
AID - 10.1007/s11325-020-02129-7 [doi]
PST - ppublish
SO  - Sleep Breath. 2021 Mar;25(1):309-314. doi: 10.1007/s11325-020-02129-7. Epub 2020 
      Jun 19.