PMID- 32563742
OWN - NLM
STAT- MEDLINE
DCOM- 20211001
LR  - 20221207
IS  - 1872-6844 (Electronic)
IS  - 0920-1211 (Linking)
VI  - 165
DP  - 2020 Sep
TI  - Association between HLA genotype and antiseizure medications (ASMs)-induced 
      maculopapular eruption among epilepsy patients in Xinjiang, China.
PG  - 106391
LID - S0920-1211(20)30116-9 [pii]
LID - 10.1016/j.eplepsyres.2020.106391 [doi]
AB  - PURPOSE: To determine genetic associations between antiseizure medications 
      (ASMs)-induced maculopapular eruption (MPE) and human leukocyte antigen (HLA) 
      variants in Xinjiang, China. METHODS: A total of 409 patients were enrolled in 
      this study, including 36 subjects with ASMs-induced MPE (case group) and 373 
      ASMs-tolerant patients (control group). We detected the whole sequence of the HLA 
      alleles in the 409 Uighur patients using next-generation sequencing (NGS). The 
      carried rate of HLA alleles were compared between the case group, the control 
      group, and the general Chinese population. RESULTS: The carried rate of 
      HLA-A*03:01, HLA-B*07:02, HLA-C*01:02, and HLA-DRB1 *06:09 allele was 
      significantly higher in the ASMs-MPE group when compared with both the 
      ASMs-tolerant group (p = 0.000, odds ratio (OR) = 23.92, 95 % confidence interval 
      (CI) = 3.96-74.84; p = 0.000, OR = 21.40, 95 % CI = 3.55-67.52; p = 0.030, OR = 
      4.69, 95 % CI = 0.90-61.73 and p = 0.000, OR = 18.94, 95 % CI = 3.15-60.58; 
      respectively), and the general Chinese population (p = 0.000, OR = 21.34, 95 % CI 
      = 3.31-38.98; p = 0.000, OR = 23.92, 95 % CI = 3.96-74.84; p = 0.019, OR = 5.53, 
      95 % CI = 0.14-19.86 and p = 0.000, OR = 21.67, 95 % CI = 3.68-11.73; 
      respectively). Moreover, the carried rate of the HLA-B*4001 allele was 
      significantly higher in the ASMs-tolerant group when compared with the ASMs-MPE 
      group (p = 0.024, OR = 5.13, 95 % CI = 1.01-9.99). CONCLUSIONS: In this study, we 
      identified for the first time that the carried rate of HLA-A*03:01, HLA-B*07:02, 
      HLA-C*01:02, and HLA-DRB1 *06:09 allele was significantly higher in the ASMs-MPE 
      group when compared with the ASMs-tolerant group.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Zhao, Ting
AU  - Zhao T
AD  - Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province 830001, China; Institute of Clinical Pharmacy, People's 
      Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Province 830001, 
      China. Electronic address: 445839342@qq.com.
FAU - Li, Hong-Jian
AU  - Li HJ
AD  - Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang Province 830001, China.
FAU - Wang, Ting-Ting
AU  - Wang TT
AD  - Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province 830001, China.
FAU - Bahatibieke, Maerjiang
AU  - Bahatibieke M
AD  - Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province 830001, China.
FAU - Jia, Li
AU  - Jia L
AD  - Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province 830001, China.
FAU - Wang, Feng
AU  - Wang F
AD  - Department of Neurology, Children's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province 830001, China.
FAU - Liu, Wen-Li
AU  - Liu WL
AD  - Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang Province 830001, China.
FAU - Ji, Yong
AU  - Ji Y
AD  - Xinjiang Dingju Biotechnology Co., Ltd., Urumqi, Xinjiang Province 830001, China.
FAU - Sun, Li
AU  - Sun L
AD  - Institute of Clinical Pharmacy, People's Hospital of Xinjiang Uygur Autonomous 
      Region, Urumqi, Xinjiang Province 830001, China.
FAU - Sun, Yan
AU  - Sun Y
AD  - Department of Neurology, Children's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province 830001, China. Electronic address: sunkefang@163.com.
FAU - Yu, Lu-Hai
AU  - Yu LH
AD  - Department of Pharmacy, People's Hospital of Xinjiang Uygur Autonomous Region, 
      Urumqi, Xinjiang Province 830001, China. Electronic address: 1523264450@qq.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200606
PL  - Netherlands
TA  - Epilepsy Res
JT  - Epilepsy research
JID - 8703089
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-B15 Antigen)
RN  - 33CM23913M (Carbamazepine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anticonvulsants/*adverse effects/therapeutic use
MH  - Asian People/genetics
MH  - Carbamazepine/therapeutic use
MH  - China/epidemiology
MH  - Drug Eruptions/*genetics
MH  - Epilepsy/*drug therapy/epidemiology/*genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - HLA Antigens/*genetics
MH  - HLA-B15 Antigen/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
OTO - NOTNLM
OT  - Antiseizure medication
OT  - Human leukocyte antigen
OT  - Maculopapular eruption
COIS- Declaration of Competing Interest None of the authors has any conflict of 
      interest to disclose. We confirm that we have read the Journal's position on 
      issues involved in ethical publication and affirm that this report is consistent 
      with those guidelines.
EDAT- 2020/06/22 06:00
MHDA- 2021/10/02 06:00
CRDT- 2020/06/22 06:00
PHST- 2020/02/21 00:00 [received]
PHST- 2020/05/08 00:00 [revised]
PHST- 2020/06/04 00:00 [accepted]
PHST- 2020/06/22 06:00 [pubmed]
PHST- 2021/10/02 06:00 [medline]
PHST- 2020/06/22 06:00 [entrez]
AID - S0920-1211(20)30116-9 [pii]
AID - 10.1016/j.eplepsyres.2020.106391 [doi]
PST - ppublish
SO  - Epilepsy Res. 2020 Sep;165:106391. doi: 10.1016/j.eplepsyres.2020.106391. Epub 
      2020 Jun 6.