PMID- 32564049
OWN - NLM
STAT- MEDLINE
DCOM- 20200720
LR  - 20200720
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 48
IP  - 285
DP  - 2020 Jun 17
TI  - Endocrine abnormalities induced by the antiviral drugs and frequency of their 
      occurrence.
PG  - 209-214
AB  - Viral infections lead to many disorders with a different course and prognosis. 
      Clinical trials are ongoing on new groups of antiviral drugs, which are very 
      promising. However, treatment with antiviral drugs causes numerous adverse 
      effects (AEs) including hormonal dysfunctions. The aim of this article is to 
      discuss endocrine abnormalities induced by the antiviral drugs including 
      frequency of their occurrence. The review is based on the available literature in 
      the Medline database and considers the latest articles describing endocrine 
      disorders with relation to antiviral therapy. The hormonal and metabolic 
      dysfunctions were discussed, including the AEs like: osteoporosis, osteomalacia, 
      hypoand hyperthyroidism, metabolic syndrome, lipodystrophy, hyperglycemia, 
      diabetes mellitus and others. Awareness of frequency and type of complications 
      caused by antiviral drugs, enables faster linking of the disease with the 
      therapy, so it allows the personalization of treatment. It's necessary to monitor 
      the general condition of the patients and appropriate diagnostic parameters that 
      it can help diagnose hormonal disorders and adjust an individual antiviral 
      therapy for the patient with endocrinopathy.
CI  - (c) 2020 MEDPRESS.
FAU - Dyrka, Kamil
AU  - Dyrka K
AD  - Medical University of Poznan, Poland: Student's Scientific Group of Department of 
      Endocrinology, Metabolism and Internal Diseases.
FAU - Miedziaszczyk, MiLosz
AU  - Miedziaszczyk M
AD  - Medical University of Poznan, Poland: Student's Scientific Circle of Clinical 
      Pharmacy of Department of Clinical Pharmacy and Biopharmacy.
FAU - Szalek, Edyta
AU  - Szalek E
AD  - Medical University of Poznan, Poland: Department of Clinical Pharmacy and 
      Biopharmacy.
FAU - Lacka, Katarzyna
AU  - Lacka K
AD  - Medical University of Poznan, Poland: Department of Endocrinology, Metabolism and 
      Internal Diseases.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 0 (Antiviral Agents)
SB  - IM
MH  - *Antiviral Agents/adverse effects
MH  - *Diabetes Mellitus/chemically induced
MH  - Drug-Related Side Effects and Adverse Reactions
MH  - Humans
MH  - *Hyperglycemia/chemically induced
MH  - *Osteoporosis/chemically induced
OTO - NOTNLM
OT  - antiviral drugs
OT  - endocrine disorders
EDAT- 2020/06/22 06:00
MHDA- 2020/07/21 06:00
CRDT- 2020/06/22 06:00
PHST- 2020/06/22 06:00 [entrez]
PHST- 2020/06/22 06:00 [pubmed]
PHST- 2020/07/21 06:00 [medline]
AID - PML285-209 [pii]
PST - ppublish
SO  - Pol Merkur Lekarski. 2020 Jun 17;48(285):209-214.