PMID- 32564329
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20220124
IS  - 1573-7322 (Electronic)
IS  - 1382-4147 (Linking)
VI  - 27
IP  - 1
DP  - 2022 Jan
TI  - Arrhythmic risk stratification by cardiac magnetic resonance tissue 
      characterization: disclosing the arrhythmic substrate within the heart muscle.
PG  - 49-69
LID - 10.1007/s10741-020-09986-0 [doi]
AB  - Sudden cardiac death (SCD) is a pivotal health problem worldwide. The 
      identification of subjects at increased risk of SCD is crucial for the accurate 
      selection of candidates for implantable cardioverter defibrillator (ICD) therapy. 
      Current strategies for arrhythmic stratification largely rely on left ventricular 
      (LV) ejection fraction (EF), mostly measured by echocardiography, and New York 
      Heart Association functional status for heart failure with reduced EF. For 
      specific diseases, such as hypertrophic and arrhythmogenic cardiomyopathy, some 
      risk scores have been proposed; however, these scores take into account some 
      parameters that are a partial reflection of the global arrhythmic risk and show a 
      suboptimal accuracy. Thanks to a more comprehensive evaluation, cardiac magnetic 
      resonance (CMR) provides insights into the heart muscle (the so-called tissue 
      characterization) identifying cardiac fibrosis as an arrhythmic substrate. 
      Combining sequences before and after administration of contrast media and mapping 
      techniques, CMR is able to characterize the myocardial tissue composition, 
      shedding light on both intracellular and extracellular alterations. Over time, 
      late gadolinium enhancement (LGE) emerged as solid prognostic marker, strongly 
      associated with major arrhythmic events regardless of LVEF, adding incremental 
      value over current strategy in ischemic heart disease and non-ischemic 
      cardiomyopathies. The evidence on a potential prognostic role of mapping imaging 
      is promising. However, mapping techniques require further investigation and 
      standardization. Disclosing the arrhythmic substrate within the myocardium, CMR 
      should be considered as part of a multiparametric approach to personalized 
      arrhythmic stratification.
CI  - (c) 2020. Springer Science+Business Media, LLC, part of Springer Nature.
FAU - Porcari, Aldostefano
AU  - Porcari A
AD  - Cardiovascular Department, Division of Cardiology, Azienda Sanitaria 
      Universitaria Giuliano Isontina (ASUGI), University of Trieste, Via Pietro 
      Valdoni 7, 34149, Trieste, Italy.
FAU - De Luca, Antonio
AU  - De Luca A
AD  - Cardiovascular Department, Division of Cardiology, Azienda Sanitaria 
      Universitaria Giuliano Isontina (ASUGI), University of Trieste, Via Pietro 
      Valdoni 7, 34149, Trieste, Italy.
FAU - Grigoratos, Chrysanthos
AU  - Grigoratos C
AD  - Fondazione CNR - Regione Toscana "G. Monasterio", Pisa, Italy.
FAU - Biondi, Federico
AU  - Biondi F
AD  - Cardiovascular Department, Division of Cardiology, Azienda Sanitaria 
      Universitaria Giuliano Isontina (ASUGI), University of Trieste, Via Pietro 
      Valdoni 7, 34149, Trieste, Italy.
FAU - Faganello, Giorgio
AU  - Faganello G
AD  - Cardiovascular Department, Division of Cardiology, Azienda Sanitaria 
      Universitaria Giuliano Isontina (ASUGI), University of Trieste, Via Pietro 
      Valdoni 7, 34149, Trieste, Italy.
FAU - Vitrella, Giancarlo
AU  - Vitrella G
AD  - Cardiovascular Department, Division of Cardiology, Azienda Sanitaria 
      Universitaria Giuliano Isontina (ASUGI), University of Trieste, Via Pietro 
      Valdoni 7, 34149, Trieste, Italy.
FAU - Nucifora, Gaetano
AU  - Nucifora G
AD  - NorthWest Cardiac Imaging Centre, Wythenshawe Hospital, Manchester University NHS 
      Foundation Trust, Manchester, UK.
FAU - Aquaro, Giovanni Donato
AU  - Aquaro GD
AD  - Fondazione CNR - Regione Toscana "G. Monasterio", Pisa, Italy.
FAU - Merlo, Marco
AU  - Merlo M
AD  - Cardiovascular Department, Division of Cardiology, Azienda Sanitaria 
      Universitaria Giuliano Isontina (ASUGI), University of Trieste, Via Pietro 
      Valdoni 7, 34149, Trieste, Italy. marco.merlo79@gmail.com.
FAU - Sinagra, Gianfranco
AU  - Sinagra G
AD  - Cardiovascular Department, Division of Cardiology, Azienda Sanitaria 
      Universitaria Giuliano Isontina (ASUGI), University of Trieste, Via Pietro 
      Valdoni 7, 34149, Trieste, Italy.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Heart Fail Rev
JT  - Heart failure reviews
JID - 9612481
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - *Contrast Media
MH  - Death, Sudden, Cardiac/etiology/prevention & control
MH  - *Gadolinium
MH  - Humans
MH  - Magnetic Resonance Imaging, Cine
MH  - Magnetic Resonance Spectroscopy
MH  - Myocardium
MH  - Predictive Value of Tests
MH  - Risk Assessment
MH  - Risk Factors
OTO - NOTNLM
OT  - Arrhythmic stratification
OT  - Cardiac magnetic resonance
OT  - Cardiomyopathies
OT  - Late gadolinium enhancement
OT  - Mapping imaging
OT  - Sudden cardiac death
EDAT- 2020/06/22 06:00
MHDA- 2022/01/27 06:00
CRDT- 2020/06/22 06:00
PHST- 2020/06/22 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2020/06/22 06:00 [entrez]
AID - 10.1007/s10741-020-09986-0 [pii]
AID - 10.1007/s10741-020-09986-0 [doi]
PST - ppublish
SO  - Heart Fail Rev. 2022 Jan;27(1):49-69. doi: 10.1007/s10741-020-09986-0.