PMID- 32565981
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Jul
TI  - Germline mutations in MEN1 are associated with the tumorigenesis of pituitary 
      adenoma associated with meningioma.
PG  - 561-568
LID - 10.3892/ol.2020.11601 [doi]
AB  - Pituitary adenoma and meningioma are two of the most common benign tumors in the 
      central nervous system. Pituitary adenoma associated with meningioma (PAM) is a 
      rare disease, the tumorigenesis of which remains unclear. Therefore, the aim of 
      the present study was to investigate the tumorigenesis of PAM. A total of 8,197 
      patients with pituitary adenoma were analyzed. Furthermore, the clinical data of 
      57 patients with PAM were compared with patients with multiple endocrine 
      neoplasia 1 (MEN-1) syndrome. Whole exome sequencing (WES) was performed on 23 
      samples from patients with PAM and the germline mutation was verified by Sanger 
      sequencing. The age of tumor penetrance (age of patients at diagnosis) for PAM 
      was significantly higher than that for patients with MEN-1. Compared with MEN-1 
      patients, there was a significant association between PAM and female sex 
      (P=0.004). Clonal analysis and phylogenetic tree construction suggested that the 
      pituitary adenoma and meningioma in PAM don't originate from a common progenitor. 
      WES revealed that 5/23 PAM samples had the recurrent germline mutation MEN1 
      c.1523G>A; p.G508D, which may be a genetic risk factor for PAM. Compared with 
      patients with sporadic pituitary adenoma, the difference was statistically 
      significant (P=0.0004). Compared with wild-type MEN1, there was a significant 
      association between the MEN1 mutation and recurrence of pituitary adenoma, young 
      age and larger diameter of the meningioma. The present study indicated that 
      germline mutations in MEN1 may be associated with the tumorigenesis of PAM.
CI  - Copyright: (c) Zhu et al.
FAU - Zhu, Haibo
AU  - Zhu H
AD  - Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital 
      Medical University, Beijing 100070, P.R. China.
FAU - Miao, Yazhou
AU  - Miao Y
AD  - Cell Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 
      Beijing 100070, P.R. China.
FAU - Shen, Yutao
AU  - Shen Y
AD  - Cell Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 
      Beijing 100070, P.R. China.
FAU - Guo, Jing
AU  - Guo J
AD  - Cell Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 
      Beijing 100070, P.R. China.
FAU - Xie, Weiyan
AU  - Xie W
AD  - Cell Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 
      Beijing 100070, P.R. China.
FAU - Zhao, Sida
AU  - Zhao S
AD  - Cell Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 
      Beijing 100070, P.R. China.
FAU - Dong, Wei
AU  - Dong W
AD  - Cell Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 
      Beijing 100070, P.R. China.
FAU - Zhang, Yazhuo
AU  - Zhang Y
AD  - Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital 
      Medical University, Beijing 100070, P.R. China.
AD  - Cell Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 
      Beijing 100070, P.R. China.
AD  - Cell Laboratory, Beijing Institute for Brain Disorders Brain Tumor Center, 
      Beijing 100070, P.R. China.
AD  - Department of Neurosurgery, China National Clinical Research Center for 
      Neurological Diseases, Beijing 100070, P.R. China.
FAU - Li, Chuzhong
AU  - Li C
AD  - Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital 
      Medical University, Beijing 100070, P.R. China.
AD  - Cell Laboratory, Beijing Neurosurgical Institute, Capital Medical University, 
      Beijing 100070, P.R. China.
AD  - Cell Laboratory, Beijing Institute for Brain Disorders Brain Tumor Center, 
      Beijing 100070, P.R. China.
AD  - Department of Neurosurgery, China National Clinical Research Center for 
      Neurological Diseases, Beijing 100070, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20200513
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC7285847
OTO - NOTNLM
OT  - MEN1
OT  - PAM
OT  - germline mutation
EDAT- 2020/06/23 06:00
MHDA- 2020/06/23 06:01
PMCR- 2020/05/13
CRDT- 2020/06/23 06:00
PHST- 2019/05/13 00:00 [received]
PHST- 2020/03/09 00:00 [accepted]
PHST- 2020/06/23 06:00 [entrez]
PHST- 2020/06/23 06:00 [pubmed]
PHST- 2020/06/23 06:01 [medline]
PHST- 2020/05/13 00:00 [pmc-release]
AID - OL-0-0-11601 [pii]
AID - 10.3892/ol.2020.11601 [doi]
PST - ppublish
SO  - Oncol Lett. 2020 Jul;20(1):561-568. doi: 10.3892/ol.2020.11601. Epub 2020 May 13.