PMID- 32566448
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 2206-3552 (Print)
IS  - 2206-3552 (Electronic)
IS  - 2206-3552 (Linking)
VI  - 5
IP  - 3
DP  - 2020
TI  - Minocycline Combined with Vancomycin for the Treatment of Methicillin-Resistant 
      Coagulase-Negative Staphylococcal Prosthetic Joint Infection Managed with 
      Exchange Arthroplasty.
PG  - 110-117
LID - 10.7150/jbji.43254 [doi]
AB  - Introduction: Treatment of methicillin-resistant (MR) staphylococcal prosthetic 
      joint infections (PJIs) remains a matter of discussion, with vancomycin-rifampin 
      combination therapy being the preferred treatment for DAIR and one-stage exchange 
      arthroplasty strategies. This study analyzes the outcomes of patients with 
      chronic methicillin-resistant coagulase-negative staphylococcal PJIs treated with 
      vancomycin-minocycline combination therapy. Methods: This prospective, single 
      center cohort study included all chronic MR coagulase-negative staphylococcal 
      PJIs (01/2004-12/2014) treated with exchange arthroplasty and at least 4 weeks of 
      minocycline-vancomycin. The following endpoints were considered: reinfection 
      including relapse (same microorganism) and a new infection (different 
      microorganism) and PJI-related deaths. Their outcomes were compared with PJIs 
      treated with rifampin-vancomycin during the same period. Results: Thirty-four 
      patients (median age, 69 years) with 22 hip and 12 knee arthroplasty infections 
      were included. Sixteen (47%) had previously been managed in another center. 
      Median vancomycin MIC of strains was 3 mg/L. Nineteen underwent one-stage, 15 
      two-stage exchange arthroplasty. After a median [IQR] follow-up of 43 [26-68] 
      months, 2 patients relapsed and 6 developed a new PJI. Compared to 36 
      rifampin-vancomycin treated PJIs, relapse- or reinfection-free survival rates 
      didn't differ, but more new infections developed in the minocycline group (6 vs 
      3; P 0.3). Conclusions: Minocycline-vancomycin combination therapy for chronic MR 
      coagulase-negative staphylococcal PJIs seems to be an interesting therapeutic 
      alternative.
CI  - (c) The author(s).
FAU - Bart, Geraldine
AU  - Bart G
AD  - Service de Medecine Interne et Rhumatologie, Groupe Hospitalier Diaconesses-Croix 
      Saint-Simon, Paris, France.
FAU - Zeller, Valerie
AU  - Zeller V
AD  - Service de Medecine Interne et Rhumatologie, Groupe Hospitalier Diaconesses-Croix 
      Saint-Simon, Paris, France.
AD  - Centre de Reference des Infections Osteo-Articulaires Complexes, Groupe 
      Hospitalier Diaconesses-Croix Saint-Simon, Paris, France.
FAU - Kerroumi, Younes
AU  - Kerroumi Y
AD  - Centre de Reference des Infections Osteo-Articulaires Complexes, Groupe 
      Hospitalier Diaconesses-Croix Saint-Simon, Paris, France.
FAU - Heym, Beate
AU  - Heym B
AD  - Centre de Reference des Infections Osteo-Articulaires Complexes, Groupe 
      Hospitalier Diaconesses-Croix Saint-Simon, Paris, France.
AD  - Laboratoire des Centres de Sante et Hopitaux d'Ile de France, Groupe Hospitalier 
      Diaconesses-Croix Saint-Simon, Paris, France.
FAU - Meyssonnier, Vanina
AU  - Meyssonnier V
AD  - Service de Medecine Interne et Rhumatologie, Groupe Hospitalier Diaconesses-Croix 
      Saint-Simon, Paris, France.
AD  - Centre de Reference des Infections Osteo-Articulaires Complexes, Groupe 
      Hospitalier Diaconesses-Croix Saint-Simon, Paris, France.
FAU - Desplaces, Nicole
AU  - Desplaces N
AD  - Centre de Reference des Infections Osteo-Articulaires Complexes, Groupe 
      Hospitalier Diaconesses-Croix Saint-Simon, Paris, France.
FAU - Kitzis, Marie Dominique
AU  - Kitzis MD
AD  - Laboratoire de Microbiologie, Groupe Hospitalier Paris Saint-Joseph, Paris, 
      France.
FAU - Ziza, Jean Marc
AU  - Ziza JM
AD  - Service de Medecine Interne et Rhumatologie, Groupe Hospitalier Diaconesses-Croix 
      Saint-Simon, Paris, France.
AD  - Centre de Reference des Infections Osteo-Articulaires Complexes, Groupe 
      Hospitalier Diaconesses-Croix Saint-Simon, Paris, France.
FAU - Marmor, Simon
AU  - Marmor S
AD  - Centre de Reference des Infections Osteo-Articulaires Complexes, Groupe 
      Hospitalier Diaconesses-Croix Saint-Simon, Paris, France.
AD  - Service de Chirurgie Osseuse et Traumatologique; Groupe Hospitalier 
      Diaconesses-Croix Saint-Simon, Paris, France.
LA  - eng
PT  - Journal Article
DEP - 20200412
PL  - Germany
TA  - J Bone Jt Infect
JT  - Journal of bone and joint infection
JID - 101701849
PMC - PMC7295649
OTO - NOTNLM
OT  - methicillin-resistant Staphylococcus
OT  - minocycline, rifampicin
OT  - prosthetic joint infection
COIS- Competing Interests: The authors have declared that no competing interest exists.
EDAT- 2020/06/23 06:00
MHDA- 2020/06/23 06:01
PMCR- 2020/04/12
CRDT- 2020/06/23 06:00
PHST- 2019/12/20 00:00 [received]
PHST- 2020/03/14 00:00 [accepted]
PHST- 2020/06/23 06:00 [entrez]
PHST- 2020/06/23 06:00 [pubmed]
PHST- 2020/06/23 06:01 [medline]
PHST- 2020/04/12 00:00 [pmc-release]
AID - jbjiv05p0110 [pii]
AID - 10.7150/jbji.43254 [doi]
PST - epublish
SO  - J Bone Jt Infect. 2020 Apr 12;5(3):110-117. doi: 10.7150/jbji.43254. eCollection 
      2020.