PMID- 32566562 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220830 IS - 2305-5839 (Print) IS - 2305-5847 (Electronic) IS - 2305-5839 (Linking) VI - 8 IP - 10 DP - 2020 May TI - Effectiveness of intravenous immunoglobulin for children with severe COVID-19: a rapid review. PG - 625 LID - 10.21037/atm-20-3305 [doi] LID - 625 AB - BACKGROUND: Intravenous immunoglobulin (IVIG) is usually used as supportive therapy, but the treatment of COVID-19 by IVIG is controversial. This rapid review aims to explore the clinical effectiveness and safety of IVIG in the treatment of children with severe COVID-19. METHODS: We systematically searched the literature on the use of IVIG in patients with COVID-19, severe acute respiratory syndrome (SARS) or Middle East respiratory syndrome (MERS), including both adults and children. We assessed the risk of bias and quality of evidence and reported the main findings descriptively. RESULTS: A total of 1,519 articles were identified by initial literature search, and finally six studies met our inclusion criteria, included one randomized controlled trial (RCT), four case series and one case report involving 198 patients. One case series showed the survival of COVID-19 patients with acute respiratory distress syndrome (ARDS) was not improved by IVIG. One case report showed high-dose IVIG could improve the outcome of COVID-19 adults. Three observational studies showed inconsistent results of the effect of IVIG on SARS patients. One RCT showed that IVIG did not reduce mortality or the incidence of nosocomial infection in adults with severe SARS. The quality of evidence was between low and very low. CONCLUSIONS: The existing evidence is insufficient to support the efficacy or safety of IVIG in the treatment of COVID-19. CI - 2020 Annals of Translational Medicine. All rights reserved. FAU - Zhang, Jingyi AU - Zhang J AD - School of Public Health, Lanzhou University, Lanzhou 730000, China. AD - Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. FAU - Yang, Yinmei AU - Yang Y AD - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. FAU - Yang, Nan AU - Yang N AD - Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. FAU - Ma, Yanfang AU - Ma Y AD - Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. FAU - Zhou, Qi AU - Zhou Q AD - The First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China. FAU - Li, Weiguo AU - Li W AD - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. FAU - Wang, Xia AU - Wang X AD - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. FAU - Huang, Liping AU - Huang L AD - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. FAU - Luo, Xufei AU - Luo X AD - School of Public Health, Lanzhou University, Lanzhou 730000, China. AD - Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. FAU - Fukuoka, Toshio AU - Fukuoka T AD - Emergency and Critical Care Center, the Department of General Medicine, Department of Research and Medical Education at Kurashiki Central Hospital, Okayama, Japan. AD - Advisory Committee in Cochrane Japan, Tokyo, Japan. FAU - Ahn, Hyeong Sik AU - Ahn HS AD - Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea. AD - Korea Cochrane Centre, Seoul, Korea. FAU - Lee, Myeong Soo AU - Lee MS AD - Korea Institute of Oriental Medicine, Daejeon, Korea. AD - University of Science and Technology, Daejeon, Korea. FAU - Luo, Zhengxiu AU - Luo Z AD - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. FAU - Chen, Yaolong AU - Chen Y AD - School of Public Health, Lanzhou University, Lanzhou 730000, China. AD - Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. AD - Lanzhou University, an Affiliate of the Cochrane China Network, Lanzhou 730000, China. AD - Chinese GRADE Center, Lanzhou 730000, China. AD - Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou University, Lanzhou 730000, China. FAU - Liu, Enmei AU - Liu E AD - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. FAU - Yang, Kehu AU - Yang K AD - School of Public Health, Lanzhou University, Lanzhou 730000, China. AD - Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China. AD - Key Laboratory of Evidence Based Medicine and Knowledge Translation of Gansu Province, Lanzhou University, Lanzhou 730000, China. FAU - Fu, Zhou AU - Fu Z AD - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing 400014, China. AD - Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China. LA - eng PT - Journal Article PL - China TA - Ann Transl Med JT - Annals of translational medicine JID - 101617978 PMC - PMC7290641 OTO - NOTNLM OT - COVID-19 OT - children OT - intravenous immunoglobulin (IVIG) OT - rapid review COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm-20-3305). MSL serves as the unpaid editorial board member of Annals of Translational Medicine from Nov 2019 to Oct 2021. The other authors have no conflicts of interest to declare. EDAT- 2020/06/23 06:00 MHDA- 2020/06/23 06:01 PMCR- 2020/05/01 CRDT- 2020/06/23 06:00 PHST- 2020/06/23 06:00 [entrez] PHST- 2020/06/23 06:00 [pubmed] PHST- 2020/06/23 06:01 [medline] PHST- 2020/05/01 00:00 [pmc-release] AID - atm-08-10-625 [pii] AID - 10.21037/atm-20-3305 [doi] PST - ppublish SO - Ann Transl Med. 2020 May;8(10):625. doi: 10.21037/atm-20-3305.