PMID- 32566615
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 2305-5839 (Print)
IS  - 2305-5847 (Electronic)
IS  - 2305-5839 (Linking)
VI  - 8
IP  - 9
DP  - 2020 May
TI  - Pulmonary light chain deposition disease: a case series and literature review.
PG  - 588
LID - 10.21037/atm-20-2708 [doi]
LID - 588
AB  - BACKGROUND: Light chain deposition disease (LCDD) is a systemic disorder 
      typically characterized by non-amyloid monoclonal immunoglobulin light chain 
      deposition in tissues. LCDD is recognized as a multisystem disease, in which the 
      kidneys and liver are often affected. However, it is rarely encountered as a 
      localized pulmonary disease. This study set out to characterize the clinical 
      manifestations and features of pulmonary light-chain deposition disease (PLCDD) 
      by conducting a retrospective analysis of clinical data obtained from patients, 
      with the aim of improving clinical understanding of PLCDD. METHODS: Data from 
      inpatients diagnosed with PLCDD at Shanghai Pulmonary Hospital (Shanghai, China) 
      between January 2010 and December 2018 were retrospectively collected and 
      analyzed. RESULTS: A total of 4 PLCDD patients confirmed with PLCDD by pulmonary 
      tissue biopsy were analyzed. All of the patients were female and were found by 
      physical examination. Chest images of each patient's lungs showed multiple cystic 
      cavities with nodules. A history of Sjogren's syndrome was present with 1 
      patient, 2 patients were diagnosed with Sjogren's syndrome after surgery 
      (including 1 diagnosed with Sjogren's syndrome in the 8th year of follow up), and 
      3 patients had leukopenia. The longest follow-up period was 8 years. During the 
      follow-up period, 2 patients developed pulmonary lesions (1 patient had an 
      enlarged original cystic lesion in basal segment of right lower lobe 2 years 
      after surgery, while the other developed new nodules 7 years after surgery). 
      CONCLUSIONS: PLCDD is characterized by multiple cystic changes with nodules in 
      both lungs and can be easily complicated by lymphoid diseases such as Sjogren's 
      syndrome. The clinical symptoms cannot be characterized, and the diagnosis 
      depends on lung biopsy.
CI  - 2020 Annals of Translational Medicine. All rights reserved.
FAU - Wei, Ping
AU  - Wei P
AD  - Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, 
      Tongji University, Shanghai 200082, China.
FAU - Tao, Rujia
AU  - Tao R
AD  - Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, 
      Tongji University, Shanghai 200082, China.
FAU - Liu, Yihan
AU  - Liu Y
AD  - Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, 
      Tongji University, Shanghai 200082, China.
FAU - Xie, Huikang
AU  - Xie H
AD  - Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, 
      Tongji University, Shanghai 200082, China.
FAU - Jiang, Sen
AU  - Jiang S
AD  - Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, 
      Tongji University, Shanghai 200082, China.
FAU - Yu, Dong
AU  - Yu D
AD  - Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, 
      Tongji University, Shanghai 200082, China.
FAU - Lu, Haiwen
AU  - Lu H
AD  - Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, 
      Tongji University, Shanghai 200082, China.
FAU - Cao, Weijun
AU  - Cao W
AD  - Department of Pulmonary and Critical Care Medicine, Shanghai Pulmonary Hospital, 
      Tongji University, Shanghai 200082, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Transl Med
JT  - Annals of translational medicine
JID - 101617978
PMC - PMC7290530
OTO - NOTNLM
OT  - Pulmonary light-chain deposition disease (PLCDD)
OT  - chest computed tomography (chest CT)
OT  - prognosis
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at http://dx.doi.org/10.21037/atm-20-2708). The authors have no 
      conflicts of interest to declare.
EDAT- 2020/06/23 06:00
MHDA- 2020/06/23 06:01
PMCR- 2020/05/01
CRDT- 2020/06/23 06:00
PHST- 2020/06/23 06:00 [entrez]
PHST- 2020/06/23 06:00 [pubmed]
PHST- 2020/06/23 06:01 [medline]
PHST- 2020/05/01 00:00 [pmc-release]
AID - atm-08-09-588 [pii]
AID - 10.21037/atm-20-2708 [doi]
PST - ppublish
SO  - Ann Transl Med. 2020 May;8(9):588. doi: 10.21037/atm-20-2708.