PMID- 32567246
OWN - NLM
STAT- MEDLINE
DCOM- 20210921
LR  - 20210921
IS  - 2050-4527 (Electronic)
IS  - 2050-4527 (Linking)
VI  - 8
IP  - 3
DP  - 2020 Sep
TI  - Human leukocyte antigen class I (A, B) and class II (DRB1) allele and haplotype 
      frequencies in Iranian patients with Buerger's disease.
PG  - 434-440
LID - 10.1002/iid3.325 [doi]
AB  - OBJECTIVE: The aim of this study was to investigate the human leukocyte antigen 
      (HLA) class I (HLA-A and HLA-B) and II (HLA-DRB1) allele and haplotype 
      frequencies in a group of Iranian patients with Buerger's disease (BD) in 
      comparison with a normal healthy control group. METHODS: A total of 70 unrelated 
      male patients and 100 healthy controls from Sina Hospital, Tehran, Iran, 
      belonging to the same ethnic background, were enrolled in this case-control 
      study. HLA-A, B, and DRB1 typing were performed by polymerase chain reaction with 
      sequence-specific primers (PCR-SSP). RESULTS: The results of this case-control 
      study showed that the frequency of the HLA-A*03:01 (odds ratio (OR) = 2.88, P 
      value (Pv) = .002), HLA-A*29:01 (OR = 15.31, Pv < .001), HLA-DRB1*04:02 
      (OR = 3.41, Pv < .001), and HLA-DRB1*16:01 (OR = 8.16, Pv < .001) was 
      significantly higher in BD patients compared with healthy controls, whereas the 
      frequency of the HLA-DRB1*01:01 (OR = 0.03, Pv < .001) was significantly lower in 
      BD patients. The most frequent extended haplotypes in our patients were 
      HLA-A*02:01-B*55:01-DRB1*04:03. CONCLUSION: This study is the first study 
      evaluating an association between the HLA pattern and BD in the patients with BD 
      from North West and North Iran.
CI  - (c) 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & 
      Sons Ltd.
FAU - Dehghani Firouzabadi, Fatemeh
AU  - Dehghani Firouzabadi F
AD  - Department of Vascular Surgery, Sina Hospital, Tehran University of Medical 
      Science, Tehran, Iran.
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
AD  - ENT and Head and Neck Research Center and Department, Five Senses Institute, 
      Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
AD  - Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of 
      Medicine, Tehran University of Medical Sciences, Tehran, Iran.
FAU - Salimi, Javad
AU  - Salimi J
AD  - Department of Vascular Surgery, Sina Hospital, Tehran University of Medical 
      Science, Tehran, Iran.
FAU - Amirzargar, Aliakbar
AU  - Amirzargar A
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Dehghani Firouzabadi, Mohammad
AU  - Dehghani Firouzabadi M
AD  - Department of Vascular Surgery, Sina Hospital, Tehran University of Medical 
      Science, Tehran, Iran.
AD  - Department of Immunology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
AD  - ENT and Head and Neck Research Center and Department, Five Senses Institute, 
      Hazrat Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
FAU - Arbabi, Hani
AU  - Arbabi H
AD  - Project Management Department, Tarbiat Modares University, Tehran, Iran.
FAU - Mousavizadeh, Seyyed M
AU  - Mousavizadeh SM
AD  - Department of Plastic Surgery, 15 Khordad Educational Hospital, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Izadpanah, Kambiz
AU  - Izadpanah K
AUID- ORCID: 0000-0003-1833-8563
AD  - Department of Vascular Surgery, Sina Hospital, Tehran University of Medical 
      Science, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20200621
PL  - England
TA  - Immun Inflamm Dis
JT  - Immunity, inflammation and disease
JID - 101635460
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Alleles
MH  - Case-Control Studies
MH  - Gene Frequency
MH  - HLA-B Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Iran
MH  - Male
MH  - *Thromboangiitis Obliterans/genetics
PMC - PMC7416031
OTO - NOTNLM
OT  - Buerger's disease
OT  - HLA-DNA typing
OT  - MHC
OT  - polymerase chain reaction
COIS- The authors declare that there are no conflict of interests.
EDAT- 2020/06/23 06:00
MHDA- 2021/09/22 06:00
PMCR- 2020/06/21
CRDT- 2020/06/23 06:00
PHST- 2020/05/15 00:00 [received]
PHST- 2020/06/08 00:00 [revised]
PHST- 2020/06/11 00:00 [accepted]
PHST- 2020/06/23 06:00 [pubmed]
PHST- 2021/09/22 06:00 [medline]
PHST- 2020/06/23 06:00 [entrez]
PHST- 2020/06/21 00:00 [pmc-release]
AID - IID3325 [pii]
AID - 10.1002/iid3.325 [doi]
PST - ppublish
SO  - Immun Inflamm Dis. 2020 Sep;8(3):434-440. doi: 10.1002/iid3.325. Epub 2020 Jun 
      21.