PMID- 32568655 OWN - NLM STAT- MEDLINE DCOM- 20201104 LR - 20210409 IS - 1524-4628 (Electronic) IS - 0039-2499 (Linking) VI - 51 IP - 7 DP - 2020 Jul TI - Matrix Metalloproteinase-9 and Monocyte Chemoattractant Protein-1 Are Associated With Collateral Status in Acute Ischemic Stroke With Large Vessel Occlusion. PG - 2232-2235 LID - 10.1161/STROKEAHA.120.029395 [doi] AB - BACKGROUND AND PURPOSE: In ischemic stroke, inflammatory status may condition the development of collateral circulation. Here we assessed the relationship between systemic inflammatory biomarkers and collateral status in large vessel occlusion before mechanical thrombectomy. METHODS: HIBISCUS-STROKE is a cohort study including acute ischemic stroke patients with large vessel occlusion treated with mechanical thrombectomy following admission magnetic resonance imaging. MMP-9 (matrix metalloproteinase-9) and MCP-1 (monocyte chemoattractant protein-1) were measured on blood sampling collected at admission. Collateral status was assessed on pretreatment Digital subtraction angiography and categorized into poor (Higashida score, 0-2) and good (Higashida score, 3-4). A multiple logistic regression model was performed to detect independent markers of good collateral status. RESULTS: One hundred and twenty-two patients were included, of them 71 patients (58.2%) had a good collateral status. In univariate analysis, low MMP-9 levels (P=0.01), high MCP-1 levels (P<0.01), a low National Institute of Health Stroke Score (P=0.046), a high diastolic blood pressure (P=0.049), the absence of tandem occlusion (P=0.046), a high Alberta Stroke Program Early CT Score (P<0.01) and a low volume on the diffusion-weighted imaging (P<0.01) were associated with good collateral status. Following multivariate analysis, low MMP-9 levels (P=0.02) and high MCP-1 levels (P<0.01) remained associated with good collateral status. CONCLUSIONS: Low MMP-9 and high MCP-1 levels were associated with good pretreatment collateral status in patients with acute ischemic stroke with large vessel occlusion. These results might suggest a relationship between collateral status and inflammation. FAU - Mechtouff, Laura AU - Mechtouff L AD - Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France. AD - INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France. FAU - Bochaton, Thomas AU - Bochaton T AD - Cardiac Intensive Care Unit (T.B.), Hospices Civils de Lyon, France. AD - INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France. FAU - Paccalet, Alexandre AU - Paccalet A AD - INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France. FAU - Crola Da Silva, Claire AU - Crola Da Silva C AD - INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France. FAU - Buisson, Marielle AU - Buisson M AD - Clinical Investigation Center, INSERM 1407 (M.B., C.A., N.M., M.O.), Hospices Civils de Lyon, France. FAU - Amaz, Camille AU - Amaz C AD - Clinical Investigation Center, INSERM 1407 (M.B., C.A., N.M., M.O.), Hospices Civils de Lyon, France. FAU - Derex, Laurent AU - Derex L AD - Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France. FAU - Ong, Elodie AU - Ong E AD - Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France. AD - INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France. FAU - Berthezene, Yves AU - Berthezene Y AD - Neuroradiology Department (Y.B., O.F.E.), Hospices Civils de Lyon, France. AD - CREATIS, CNRS UMR 5220, INSERM U1044 (Y.B.), University Lyon 1, France. FAU - Eker, Omer Faruk AU - Eker OF AD - Neuroradiology Department (Y.B., O.F.E.), Hospices Civils de Lyon, France. FAU - Dufay, Nathalie AU - Dufay N AD - NeuroBioTec, CRB (N.D.), Hospices Civils de Lyon, France. FAU - Mewton, Nathan AU - Mewton N AD - Clinical Investigation Center, INSERM 1407 (M.B., C.A., N.M., M.O.), Hospices Civils de Lyon, France. FAU - Ovize, Michel AU - Ovize M AD - Clinical Investigation Center, INSERM 1407 (M.B., C.A., N.M., M.O.), Hospices Civils de Lyon, France. AD - INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France. FAU - Cho, Tae-Hee AU - Cho TH AD - Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France. AD - INSERM U1060, CarMeN laboratory (L.M., T.B., A.P., C.C.D.S., E.O., M.O., T.-H.C.), University Lyon 1, France. FAU - Nighoghossian, Norbert AU - Nighoghossian N AD - Stroke Department (L.M., L.D., E.O., T.-H.C., N.N.), Hospices Civils de Lyon, France. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20200617 PL - United States TA - Stroke JT - Stroke JID - 0235266 RN - 0 (Biomarkers) RN - 0 (CCL2 protein, human) RN - 0 (Chemokine CCL2) RN - EC 3.4.24.35 (MMP9 protein, human) RN - EC 3.4.24.35 (Matrix Metalloproteinase 9) SB - IM CIN - Stroke. 2021 Jan;52(1):e16. PMID: 33370182 CIN - Stroke. 2021 Jan;52(1):e15. PMID: 33370195 MH - Adult MH - Aged MH - Aged, 80 and over MH - Biomarkers/blood MH - Brain Ischemia/blood/pathology MH - Carotid Artery Diseases/complications MH - Chemokine CCL2/*blood MH - Cohort Studies MH - *Collateral Circulation MH - Female MH - Humans MH - Inflammation/blood MH - Male MH - Matrix Metalloproteinase 9/*blood MH - Middle Aged MH - Stroke/*blood/*pathology OTO - NOTNLM OT - brain edema OT - collateral circulation OT - digital subtraction angiography OT - matrix metalloproteinase 9 OT - monocyte chemoattractant proteins EDAT- 2020/06/23 06:00 MHDA- 2020/11/05 06:00 CRDT- 2020/06/23 06:00 PHST- 2020/06/23 06:00 [entrez] PHST- 2020/06/23 06:00 [pubmed] PHST- 2020/11/05 06:00 [medline] AID - 10.1161/STROKEAHA.120.029395 [doi] PST - ppublish SO - Stroke. 2020 Jul;51(7):2232-2235. doi: 10.1161/STROKEAHA.120.029395. Epub 2020 Jun 17.