PMID- 32569519
OWN - NLM
STAT- MEDLINE
DCOM- 20210601
LR  - 20210601
IS  - 1545-4509 (Electronic)
IS  - 0066-4154 (Linking)
VI  - 89
DP  - 2020 Jun 20
TI  - HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity.
PG  - 717-739
LID - 10.1146/annurev-biochem-011520-102754 [doi]
AB  - In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble 
      with a peptide and take it to the cell surface for surveillance by lymphocytes. 
      These include natural killer (NK) cells and gammadelta T cells of innate immunity and alphabeta 
      T cells of adaptive immunity. In healthy cells, the presented peptides derive 
      from human proteins, to which lymphocytes are tolerant. In pathogen-infected 
      cells, HLA class I expression is perturbed. Reduced HLA class I expression is 
      detected by KIR and CD94:NKG2A receptors of NK cells. Almost any change in 
      peptide presentation can be detected by alphabeta CD8(+) T cells. In responding to 
      extracellular pathogens, HLA class II glycoproteins, expressed by specialized 
      antigen-presenting cells, present peptides to alphabeta CD4(+) T cells. In comparison to 
      the families of major histocompatibility complex (MHC) class I, MHC class II and 
      alphabeta T cell receptors, the antigenic specificity of the gammadelta T cell receptors is 
      incompletely understood.
FAU - Djaoud, Zakia
AU  - Djaoud Z
AD  - Department of Structural Biology and Department of Microbiology and Immunology, 
      Stanford University School of Medicine, Stanford, California 94305, USA; email: 
      zdjaoud@stanford.edu, peropa@stanford.edu.
FAU - Parham, Peter
AU  - Parham P
AD  - Department of Structural Biology and Department of Microbiology and Immunology, 
      Stanford University School of Medicine, Stanford, California 94305, USA; email: 
      zdjaoud@stanford.edu, peropa@stanford.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Biochem
JT  - Annual review of biochemistry
JID - 2985150R
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (KLRD1 protein, human)
RN  - 0 (NK Cell Lectin-Like Receptor Subfamily D)
RN  - 0 (Receptors, Antigen, T-Cell, alpha-beta)
RN  - 0 (Receptors, Antigen, T-Cell, gamma-delta)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Antigen Presentation
MH  - CD8-Positive T-Lymphocytes/cytology/immunology
MH  - Evolution, Molecular
MH  - Gene Expression Regulation
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*chemistry/classification/genetics/immunology
MH  - Histocompatibility Antigens Class 
      II/*chemistry/classification/genetics/immunology
MH  - Humans
MH  - *Immunity, Cellular
MH  - Immunity, Innate
MH  - Killer Cells, Natural/cytology/immunology
MH  - Models, Molecular
MH  - NK Cell Lectin-Like Receptor Subfamily D/*chemistry/genetics/immunology
MH  - Protein Interaction Domains and Motifs
MH  - Protein Structure, Secondary
MH  - Receptors, Antigen, T-Cell, alpha-beta/*chemistry/genetics/immunology
MH  - Receptors, Antigen, T-Cell, gamma-delta/*chemistry/genetics/immunology
MH  - Receptors, KIR/*chemistry/classification/genetics/immunology
MH  - Signal Transduction
OTO - NOTNLM
OT  - HLA
OT  - KIR
OT  - TCR
OT  - haplotype
OT  - lymphocyte
OT  - polymorphism
EDAT- 2020/06/23 06:00
MHDA- 2021/06/02 06:00
CRDT- 2020/06/23 06:00
PHST- 2020/06/23 06:00 [entrez]
PHST- 2020/06/23 06:00 [pubmed]
PHST- 2021/06/02 06:00 [medline]
AID - 10.1146/annurev-biochem-011520-102754 [doi]
PST - ppublish
SO  - Annu Rev Biochem. 2020 Jun 20;89:717-739. doi: 
      10.1146/annurev-biochem-011520-102754.