PMID- 32569983
OWN - NLM
STAT- MEDLINE
DCOM- 20210426
LR  - 20210426
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 400
DP  - 2020 Dec 5
TI  - Increased serum levels of aldehydes are associated with cardiovascular disease 
      and cardiovascular risk factors in adults.
PG  - 123134
LID - S0304-3894(20)31123-7 [pii]
LID - 10.1016/j.jhazmat.2020.123134 [doi]
AB  - Previous studies have identified several genetic and environmental risk factors 
      for cardiovascular disease (CVD), but little is known about the associations 
      between serum aldehydes and CVD risk. Herein, we examined associations between 
      serum levels of aldehydes and the risk of CVD and CVD subtypes among 1947 U.S. 
      adults participating in the National Health and Nutrition Examination Survey 
      (NHANES) 2013-2014. Bayesian kernel machine regression (BKMR) was used to analyze 
      the combined effect of serum aldehydes on the overall risk of CVD. We found that 
      isopentanaldehyde concentrations were positively associated with the odds of CVD 
      (adjusted odds ratio (aOR): 2.17; 95 % confidence interval (95 % CI): 1.36, 
      3.46). The result of BKMR also indicated a positive association of mixed 
      aldehydes with CVD risk. Isopentanaldehyde had the highest posterior inclusion 
      probabilities (PIP = 0.90). Each one-unit (ng/mL) increase in the 
      isopentanaldehyde concentration was associated with a 25.0 mg/dL increase in 
      triglycerides and a 0.9 x 10(9)/L increase in white blood cell (WBC) count in the 
      fully adjusted model. Current evidence suggests that isopentanaldehyde may 
      increase the risk of CVD by elevating triglycerides and WBC count.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Xu, Cheng
AU  - Xu C
AD  - State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing 
      Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of 
      Ministry of Education, Center for Global Health, Nanjing Medical University, 
      Nanjing, China.
FAU - Liang, Jingjia
AU  - Liang J
AD  - State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing 
      Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of 
      Ministry of Education, Center for Global Health, Nanjing Medical University, 
      Nanjing, China.
FAU - Xu, Shuqin
AU  - Xu S
AD  - State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing 
      Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of 
      Ministry of Education, Center for Global Health, Nanjing Medical University, 
      Nanjing, China.
FAU - Liu, Qian
AU  - Liu Q
AD  - State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing 
      Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of 
      Ministry of Education, Center for Global Health, Nanjing Medical University, 
      Nanjing, China.
FAU - Xu, Jin
AU  - Xu J
AD  - State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing 
      Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of 
      Ministry of Education, Center for Global Health, Nanjing Medical University, 
      Nanjing, China; Department of Maternal, Child, and Adolescent Health, School of 
      Public Health, Nanjing Medical University, Nanjing, China.
FAU - Gu, Aihua
AU  - Gu A
AD  - State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing 
      Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of 
      Ministry of Education, Center for Global Health, Nanjing Medical University, 
      Nanjing, China. Electronic address: aihuagu@njmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200611
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Aldehydes)
SB  - IM
MH  - Adult
MH  - *Aldehydes/blood
MH  - Bayes Theorem
MH  - *Cardiovascular Diseases/blood/epidemiology
MH  - Heart Disease Risk Factors
MH  - Humans
MH  - Nutrition Surveys
MH  - Risk Factors
OTO - NOTNLM
OT  - Aldehydes
OT  - BKMR
OT  - Cardiovascular disease
OT  - Triglycerides
OT  - White blood cells count
EDAT- 2020/06/23 06:00
MHDA- 2021/04/27 06:00
CRDT- 2020/06/23 06:00
PHST- 2020/04/11 00:00 [received]
PHST- 2020/06/02 00:00 [revised]
PHST- 2020/06/04 00:00 [accepted]
PHST- 2020/06/23 06:00 [pubmed]
PHST- 2021/04/27 06:00 [medline]
PHST- 2020/06/23 06:00 [entrez]
AID - S0304-3894(20)31123-7 [pii]
AID - 10.1016/j.jhazmat.2020.123134 [doi]
PST - ppublish
SO  - J Hazard Mater. 2020 Dec 5;400:123134. doi: 10.1016/j.jhazmat.2020.123134. Epub 
      2020 Jun 11.