PMID- 32570271
OWN - NLM
STAT- MEDLINE
DCOM- 20220114
LR  - 20220114
IS  - 1530-0447 (Electronic)
IS  - 0031-3998 (Linking)
VI  - 89
IP  - 4
DP  - 2021 Mar
TI  - Progression of left ventricular diastolic function in the neonate and early 
      childhood from transmitral color M-mode filling analysis.
PG  - 987-995
LID - 10.1038/s41390-020-1011-6 [doi]
AB  - BACKGROUND: We implemented sophisticated color M-mode analysis to assess 
      age-dependent progression of left ventricular (LV) diastolic function. METHODS: 
      Normal infants were prospectively enrolled for serial echocardiograms at 1 week, 
      1 month, 6 months, 1 year, and 2 years. From color M-mode scans, propagation 
      velocity (V(P)), strength of filling (V(S)), and intraventricular pressure 
      difference (IVPD) in 3 segments along apex-to-mitral valve scan line were 
      measured. RESULTS: Age-wise comparisons of diastolic filling from 121 
      echocardiograms in 31 infants showed V(P) (cm/s), V(S) (cm(2)/s), and E-wave IVPD 
      (mmHg) at 1 week to be 66.2 +/- 11.9, 75.3 +/- 19.9, and 1.5 +/- 0.4, respectively, 
      while V(P), V(S), and E-wave IVPD at 1 month were 80.3 +/- 14.4, 101.2 +/- 28.3, and 
      2.42 +/- 1.1, respectively. There were significant differences in V(P) and 
      segmental IVPD between first week and first month (p < 0.005) and IVPD between 
      the age groups (p < 0.001). CONCLUSIONS: Comprehensive analysis of transmitral 
      color M-mode data is feasible in infants, enabling calculation of pressure drop 
      between the LV base and apex and strength of propagation from two distinct 
      slopes. Profound changes very early followed by relatively constant filling 
      mechanics in later infancy indicate significant LV maturation occurring during 
      the first month of life. IMPACT: We implemented sophisticated analytic methods 
      for color M-mode echocardiography in infants to assess age- and 
      dimension-dependent changes in left ventricular diastolic function. Comprehensive 
      characterization of transmitral color M-mode flow was feasible, enabling 
      calculation of pressure drop between left ventricular base and apex and strength 
      of propagation. Left ventricular diastolic filling function has predictable 
      maturational progression, with significant differences in the intraventricular 
      pressure between infants from birth to 2 years. This study forms the basis for 
      future studies to examine alteration of early diastolic filling in congenital 
      heart disease.
FAU - Erickson, Collin T
AU  - Erickson CT
AD  - Department of Pediatric Cardiology, University of Nebraska College of Medicine 
      and Children's Hospital and Medical Center, Omaha, NE, USA.
FAU - Meyers, Brett
AU  - Meyers B
AD  - Department of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
FAU - Li, Ling
AU  - Li L
AD  - Department of Pediatric Cardiology, University of Nebraska College of Medicine 
      and Children's Hospital and Medical Center, Omaha, NE, USA.
FAU - Craft, Mary
AU  - Craft M
AD  - Department of Pediatric Cardiology, University of Nebraska College of Medicine 
      and Children's Hospital and Medical Center, Omaha, NE, USA.
FAU - Jani, Vivek
AU  - Jani V
AD  - Taussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, 
      Baltimore, MD, USA.
FAU - Bliamptis, John
AU  - Bliamptis J
AD  - Taussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, 
      Baltimore, MD, USA.
FAU - Moukagna, Karl Stessy Bisselou
AU  - Moukagna KSB
AD  - Department of Pediatric Cardiology, University of Nebraska College of Medicine 
      and Children's Hospital and Medical Center, Omaha, NE, USA.
FAU - Danford, David A
AU  - Danford DA
AD  - Department of Pediatric Cardiology, University of Nebraska College of Medicine 
      and Children's Hospital and Medical Center, Omaha, NE, USA.
FAU - Vlachos, Pavlos
AU  - Vlachos P
AD  - Department of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
FAU - Kutty, Shelby
AU  - Kutty S
AD  - Taussig Heart Center, Department of Pediatrics, Johns Hopkins Hospital, 
      Baltimore, MD, USA. skutty1@jhmi.edu.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20200622
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
SB  - IM
MH  - Blood Flow Velocity
MH  - Child, Preschool
MH  - Diastole
MH  - Disease Progression
MH  - Echocardiography
MH  - Echocardiography, Doppler, Color/methods
MH  - Heart/*diagnostic imaging
MH  - Heart Ventricles/diagnostic imaging
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Function, Left
MH  - Ventricular Pressure
EDAT- 2020/06/23 06:00
MHDA- 2022/01/15 06:00
CRDT- 2020/06/23 06:00
PHST- 2019/10/29 00:00 [received]
PHST- 2020/06/03 00:00 [accepted]
PHST- 2020/05/22 00:00 [revised]
PHST- 2020/06/23 06:00 [pubmed]
PHST- 2022/01/15 06:00 [medline]
PHST- 2020/06/23 06:00 [entrez]
AID - 10.1038/s41390-020-1011-6 [pii]
AID - 10.1038/s41390-020-1011-6 [doi]
PST - ppublish
SO  - Pediatr Res. 2021 Mar;89(4):987-995. doi: 10.1038/s41390-020-1011-6. Epub 2020 
      Jun 22.