PMID- 32570911
OWN - NLM
STAT- MEDLINE
DCOM- 20210301
LR  - 20210301
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 12
IP  - 6
DP  - 2020 Jun 18
TI  - Zinc Oxide Exerts Anti-Inflammatory Properties on Human Placental Cells.
LID - 10.3390/nu12061822 [doi]
LID - 1822
AB  - BACKGROUND: An aberrant and persistent inflammatory state at the fetal-maternal 
      interface is considered as a key contributor in compromised pregnancies. Decidual 
      endothelial cells (DECs) play a pivotal role in the control of the local decidual 
      inflammation. The aim of the current study was to determine whether dietary 
      supplement with zinc oxide (ZnO), due to its very low adverse effects, may be 
      useful for modulating the inflammatory response in the first trimester of 
      pregnancy. METHODS: The anti-inflammatory properties of ZnO in pregnancy were 
      evaluated by in vitro tests on endothelial cells isolated from normal deciduas 
      and on a trophoblast cell line (HTR8/Svneo). The effects of this treatment were 
      analyzed in terms of adhesion molecule expression and inflammatory cytokine 
      secretion, by real time-quantitative PCR (RT-qPCR) and enzyme-linked 
      immunosorbent assay (ELISA). RESULTS: Our data showed that ZnO was able to reduce 
      the inflammatory response of DECs, in terms of vascular cell adhesion molecule-1 
      (VCAM-1), interleukin (IL)-8, IL-6, tumor necrosis factor-alpha (TNF-alpha) and monocyte 
      chemoattractant protein-1 (MCP-1) expression induced by TNF-alpha stimulation. This 
      compound exerted no effect on intracellular adhesion molecule-1 (ICAM-1) 
      exocytosis induced by TNF-alpha on stimulated trophoblast cells, but significantly 
      reduced their IL-6 expression. CONCLUSION: According to these results, it can be 
      suggested that the ZnO supplement, through its modulation of the pro-inflammatory 
      response of DECs, can be used in pregnancy for the prevention of local decidual 
      inflammation.
FAU - Balduit, Andrea
AU  - Balduit A
AUID- ORCID: 0000-0001-5902-3205
AD  - Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
FAU - Mangogna, Alessandro
AU  - Mangogna A
AUID- ORCID: 0000-0001-7910-1274
AD  - Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
FAU - Agostinis, Chiara
AU  - Agostinis C
AUID- ORCID: 0000-0002-8315-2258
AD  - Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34134 Trieste, 
      Italy.
FAU - Zito, Gabriella
AU  - Zito G
AUID- ORCID: 0000-0002-7836-4934
AD  - Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34134 Trieste, 
      Italy.
FAU - Romano, Federico
AU  - Romano F
AUID- ORCID: 0000-0003-2157-8330
AD  - Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34134 Trieste, 
      Italy.
FAU - Ricci, Giuseppe
AU  - Ricci G
AUID- ORCID: 0000-0002-8031-1102
AD  - Institute for Maternal and Child Health, IRCCS Burlo Garofolo, 34134 Trieste, 
      Italy.
AD  - Department of Medical, Surgical and Health Science, University of Trieste, 34129 
      Trieste, Italy.
FAU - Bulla, Roberta
AU  - Bulla R
AUID- ORCID: 0000-0003-1737-5776
AD  - Department of Life Sciences, University of Trieste, 34127 Trieste, Italy.
LA  - eng
GR  - RC20/16, RC23/18, RC24/19/This work was supported by grants from the Institute 
      for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy/
PT  - Journal Article
DEP - 20200618
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Anti-Inflammatory Agents)
RN  - SOI2LOH54Z (Zinc Oxide)
SB  - IM
MH  - Adult
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - *Dietary Supplements
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - In Vitro Techniques
MH  - Inflammation/*prevention & control
MH  - Placenta/*drug effects
MH  - Polymerase Chain Reaction
MH  - Pregnancy
MH  - Pregnancy Trimester, First
MH  - Young Adult
MH  - Zinc Oxide/*pharmacology
PMC - PMC7353449
OTO - NOTNLM
OT  - dietary supplement
OT  - endothelium
OT  - inflammation
OT  - inflammatory cytokines
OT  - pregnancy
OT  - zinc oxide
COIS- In adherence to the conflict of interest policy recommended by the International 
      Committee of Medical Journal Editors (ICMJE), authors state explicitly that 
      potential conflicts of interest do not exist for this research work.
EDAT- 2020/06/24 06:00
MHDA- 2021/03/02 06:00
PMCR- 2020/06/01
CRDT- 2020/06/24 06:00
PHST- 2020/05/01 00:00 [received]
PHST- 2020/06/07 00:00 [revised]
PHST- 2020/06/16 00:00 [accepted]
PHST- 2020/06/24 06:00 [entrez]
PHST- 2020/06/24 06:00 [pubmed]
PHST- 2021/03/02 06:00 [medline]
PHST- 2020/06/01 00:00 [pmc-release]
AID - nu12061822 [pii]
AID - nutrients-12-01822 [pii]
AID - 10.3390/nu12061822 [doi]
PST - epublish
SO  - Nutrients. 2020 Jun 18;12(6):1822. doi: 10.3390/nu12061822.