PMID- 32572434 OWN - NLM STAT- MEDLINE DCOM- 20200924 LR - 20200924 IS - 0371-0874 (Print) IS - 0371-0874 (Linking) VI - 72 IP - 3 DP - 2020 Jun 25 TI - [The effects and mechanism of caloric restriction on energy metabolism]. PG - 371-381 AB - Caloric restriction (CR) is explored to limit the caloric intake without malnutrition. CR can affect the levels of various metabolites in organism, such as lipids, free fatty acids, ketones, bile acids and amino acids, etc, and is thought being able to extend the lifespan, postpone and reduce the incidence of age-related disorders (e.g., type 2 diabetes, cancer and cardiovascular diseases). These effects are mainly attributed to the role of CR in energy metabolism. The mechanism of CR on energy metabolism is closely related to biological clock, hormonal production, gastrointestinal flora and inflammation. Here we briefly review the effects and mechanism of CR on energy metabolism. FAU - Fan, Xiao-Na AU - Fan XN AD - Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Chen, Lin-Xi AU - Chen LX AD - Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China. FAU - Xu, Ge-Yang AU - Xu GY AD - Department of Physiology, School of Medicine, Jinan University, Guangzhou 510632, China. xugeyangliang@163.com. LA - chi PT - Journal Article PL - China TA - Sheng Li Xue Bao JT - Sheng li xue bao : [Acta physiologica Sinica] JID - 20730130R SB - IM MH - *Caloric Restriction MH - *Diabetes Mellitus, Type 2 MH - Energy Metabolism MH - Humans MH - Longevity EDAT- 2020/06/24 06:00 MHDA- 2020/09/25 06:00 CRDT- 2020/06/24 06:00 PHST- 2020/06/24 06:00 [entrez] PHST- 2020/06/24 06:00 [pubmed] PHST- 2020/09/25 06:00 [medline] PST - ppublish SO - Sheng Li Xue Bao. 2020 Jun 25;72(3):371-381.