PMID- 32573395
OWN - NLM
STAT- MEDLINE
DCOM- 20210615
LR  - 20210615
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 42
IP  - 8
DP  - 2020 Aug
TI  - An evidence of brain-heart disorder: mental stress-induced myocardial ischemia 
      regulated by inflammatory cytokines.
PG  - 670-675
LID - 10.1080/01616412.2020.1783879 [doi]
AB  - OBJECTIVE: Underlying Coronary Artery Disease (CAD) complicated by Mental 
      Stress-Induced Myocardial Ischemia (MSIMI) has been linked with an increased risk 
      for adverse cardiovascular events and even sudden death. However, the underlying 
      mechanisms of MSIMI remain unknown. In this study, we investigated cytokine 
      levels at baseline inflammation status and during acute inflammatory responses to 
      mental stress in patients with known CAD who presented with MSIMI. METHOD: 77 
      patients with known CAD were recruited and all underwent echocardiography before 
      and during arithmetic stress task. MSIMI was diagnosed by new or worsening wall 
      motion abnormalities greater than or equal to a 5% reduction of left ventricle 
      ejection fraction. Inflammatory markers were measured both before and immediately 
      after the Mental Stress (MS) by ELISA kits. Repeated measures models were used to 
      report the responses and mixed linear regression models were used to report the 
      differences between MSIMI negative and positive patients. RESULT: MS induced a 
      significant increase in Stromal Cell-Derived Factor-1alpha (SDF-1alpha) and Monocyte 
      Chemoattractant Protein-1 (MCP-1) in all subjects; 20.78% of the patients with 
      known CAD developed MSIMI during the arithmetic task. MSIMI positive patients had 
      significantly lower baseline levels of Interleukin-1beta (IL-1beta) and Tumor Necrosis 
      Factor-alpha (TNF-alpha), but a higher response in levels of SDF-1alpha than MSIMI negative 
      patients. CONCLUSION: MS can induce acute inflammatory responses. MSIMI is 
      associated with lower levels of IL-1beta and TNF-alpha at baseline and higher levels of 
      SDF-1alpha in response to MS.
FAU - Liu, Meiyan
AU  - Liu M
AD  - Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical 
      University , Beijing, China.
FAU - Liu, Jianyang
AU  - Liu J
AD  - Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical 
      University , Beijing, China.
FAU - Zhang, Lijun
AU  - Zhang L
AD  - Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical 
      University , Beijing, China.
FAU - Xu, Wan
AU  - Xu W
AD  - Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical 
      University , Beijing, China.
FAU - He, Dongfang
AU  - He D
AD  - Department of Cardiology, Beijing Anzhen Hospital Affiliated to Capital Medical 
      University , Beijing, China.
FAU - Wei, Wanlin
AU  - Wei W
AD  - Department of Cardiology, PLA Army General Hospital , Beijing, China.
FAU - Ge, Yingbin
AU  - Ge Y
AD  - Department of Physiology, Nanjing Medical University , Jiangsu, China.
FAU - Dandu, Chaitu
AU  - Dandu C
AD  - Department of Neurosurgery, Wayne State University School of Medicine , MI, USA.
LA  - eng
PT  - Journal Article
DEP - 20200623
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Inflammation/*blood/complications
MH  - Inflammation Mediators/blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Ischemia/*blood/complications
MH  - Stress, Psychological/*blood/complications
OTO - NOTNLM
OT  - CAD
OT  - IL-1beta
OT  - MCP-1
OT  - MSIMI
OT  - SDF-1alpha
OT  - TNF-alpha
EDAT- 2020/06/24 06:00
MHDA- 2021/06/16 06:00
CRDT- 2020/06/24 06:00
PHST- 2020/06/24 06:00 [pubmed]
PHST- 2021/06/16 06:00 [medline]
PHST- 2020/06/24 06:00 [entrez]
AID - 10.1080/01616412.2020.1783879 [doi]
PST - ppublish
SO  - Neurol Res. 2020 Aug;42(8):670-675. doi: 10.1080/01616412.2020.1783879. Epub 2020 
      Jun 23.