PMID- 32573832
OWN - NLM
STAT- MEDLINE
DCOM- 20210310
LR  - 20210310
IS  - 1939-1676 (Electronic)
IS  - 0891-6640 (Print)
IS  - 0891-6640 (Linking)
VI  - 34
IP  - 4
DP  - 2020 Jul
TI  - Prevalence and characterization of hypoadrenocorticism in dogs with signs of 
      chronic gastrointestinal disease: A multicenter study.
PG  - 1399-1405
LID - 10.1111/jvim.15752 [doi]
AB  - BACKGROUND: Dogs with hypoadrenocorticism (HA) frequently show signs of 
      gastrointestinal disease (SGD). The prevalence of dogs presented for chronic SGD 
      with HA is unknown. OBJECTIVES: The aims of this study were to determine the 
      prevalence of HA in dogs with chronic SGD and to identify clinical and laboratory 
      variables for HA in this population. ANIMALS: One hundred fifty-one dogs with 
      chronic SGD. METHODS: In this multicentered prevalence study a standardized 
      workup was performed in prospectively enrolled dogs with SGD > 3 weeks duration. 
      Basal serum cortisol concentration was measured in every dog with ACTH 
      stimulation test (ACTHST) if basal serum cortisol concentration was <3 mug/dL. 
      RESULTS: Basal serum cortisol concentration was <3 mug/dL in 80/151 (53%) dogs, 
      <2 mug/dL in 42/151 (28%) dogs, and < 1 mug/dL in 9/151 (6%) dogs. In 6/151 dogs HA 
      was diagnosed based on ACTHST (stimulated serum cortisol 
      concentration < 2 mug/dL), a prevalence of 4%. There was no difference in history, 
      physical examination, and laboratory variables between dogs with HA and those 
      with other causes of chronic SGD. In 4/6 dogs with HA, there was melena or 
      hematochezia indicating gastrointestinal blood loss. Hyperkalemia, hyponatremia, 
      or both was not observed in any dog. CONCLUSION AND CLINICAL IMPORTANCE: The 
      prevalence of HA among dogs with chronic SGD is higher than in the general 
      population. Based on these results, testing adrenal function should be performed 
      as a standard screening test in dogs with chronic SGD to differentiate between HA 
      and chronic enteropathies.
CI  - (c) 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley 
      Periodicals, Inc. on behalf of the American College of Veterinary Internal 
      Medicine.
FAU - Hauck, Christina
AU  - Hauck C
AUID- ORCID: 0000-0002-1665-0740
AD  - Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig 
      Maximilian University of Munich, Munich, Germany.
FAU - Schmitz, Silke S
AU  - Schmitz SS
AUID- ORCID: 0000-0003-1084-7013
AD  - Hospital for Small Animals, Royal (Dick) School of Veterinary Studies and The 
      Roslin Institute, University of Edinburgh, Edinburgh, UK.
FAU - Burgener, Iwan A
AU  - Burgener IA
AUID- ORCID: 0000-0002-8516-0040
AD  - Department for Companion Animals and Horses, Clinic for Small Animal Internal 
      Medicine, University of Veterinary Medicine, Vienna, Austria.
FAU - Wehner, Astrid
AU  - Wehner A
AD  - Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig 
      Maximilian University of Munich, Munich, Germany.
FAU - Neiger, Reto
AU  - Neiger R
AD  - Small Animal Hospital Hofheim, Hofheim, Germany.
FAU - Kohn, Barbara
AU  - Kohn B
AD  - Clinic for Small Animals, Freie Universitat Berlin, Berlin, Germany.
FAU - Rieker, Thomas
AU  - Rieker T
AD  - AniCura Kleintierspezialisten Ravensburg, Ravensburg, Germany.
FAU - Reese, Sven
AU  - Reese S
AD  - Institute of Anatomy, Histology and Embryology, LMU Munich, Munich, Germany.
FAU - Unterer, Stefan
AU  - Unterer S
AD  - Clinic of Small Animal Medicine, Centre for Clinical Veterinary Medicine, Ludwig 
      Maximilian University of Munich, Munich, Germany.
LA  - eng
GR  - IDEXX Laboratories/
PT  - Journal Article
PT  - Multicenter Study
DEP - 20200623
PL  - United States
TA  - J Vet Intern Med
JT  - Journal of veterinary internal medicine
JID - 8708660
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenal Insufficiency/blood/diagnosis/epidemiology/*veterinary
MH  - Adrenocorticotropic Hormone/pharmacology
MH  - Animals
MH  - Dog Diseases/blood/*diagnosis/epidemiology
MH  - Dogs
MH  - Female
MH  - Gastrointestinal Diseases/blood/diagnosis/*veterinary
MH  - Gastrointestinal Hemorrhage/veterinary
MH  - Hydrocortisone/blood
MH  - Male
MH  - Melena/veterinary
MH  - Prevalence
MH  - Prospective Studies
PMC - PMC7379021
OTO - NOTNLM
OT  - Addison's disease
OT  - atypical hypoadrenocorticism
OT  - chronic diarrhea
OT  - cortisol
COIS- Some of the hematology, serum biochemistry profiles, and serum cortisol 
      measurements were performed free of charge by IDEXX Laboratories, Ludwigsburg, 
      Germany. Authors declare no conflict of interest.
EDAT- 2020/06/24 06:00
MHDA- 2021/03/11 06:00
PMCR- 2020/07/01
CRDT- 2020/06/24 06:00
PHST- 2019/05/09 00:00 [received]
PHST- 2020/02/15 00:00 [revised]
PHST- 2020/02/21 00:00 [accepted]
PHST- 2020/06/24 06:00 [pubmed]
PHST- 2021/03/11 06:00 [medline]
PHST- 2020/06/24 06:00 [entrez]
PHST- 2020/07/01 00:00 [pmc-release]
AID - JVIM15752 [pii]
AID - 10.1111/jvim.15752 [doi]
PST - ppublish
SO  - J Vet Intern Med. 2020 Jul;34(4):1399-1405. doi: 10.1111/jvim.15752. Epub 2020 
      Jun 23.