PMID- 32574399
OWN - NLM
STAT- MEDLINE
DCOM- 20210519
LR  - 20230829
IS  - 1538-7836 (Electronic)
IS  - 1538-7836 (Linking)
VI  - 18
IP  - 9
DP  - 2020 Sep
TI  - Platelet MAPKs-a 20+ year history: What do we really know?
PG  - 2087-2102
LID - 10.1111/jth.14967 [doi]
AB  - The existence of mitogen activated protein kinases (MAPKs) in platelets has been 
      known for more than 20 years. Since that time hundreds of reports have been 
      published describing the conditions that cause MAPK activation in platelets and 
      their role in regulating diverse platelet functions from the molecular to 
      physiological level. However, this cacophony of reports, with inconsistent and 
      sometimes contradictory findings, has muddied the waters leading to great 
      confusion. Since the last review of platelet MAPKs was published more than a 
      decade ago, there have been more than 50 reports, including the description of 
      novel knockout mouse models, that have furthered our knowledge. Therefore, we 
      undertook an extensive literature review to delineate what is known about 
      platelet MAPKs. We specifically discuss what is currently known about how MAPKs 
      are activated and what signaling cascades they regulate in platelets 
      incorporating recent findings from knockout mouse models. In addition, we will 
      discuss the role each MAPK plays in regulating distinct platelet functions. In 
      doing so, we hope to clarify the role for MAPKs and identify knowledge gaps in 
      this field that await future researchers. In addition, we discuss the limitations 
      of current studies with a particular focus on the off-target effects of commonly 
      used MAPK inhibitors. We conclude with a look at the clinical utility of MAPK 
      inhibitors as potential antithrombotic therapies with an analysis of current 
      clinical trial data.
CI  - (c) 2020 International Society on Thrombosis and Haemostasis.
FAU - Patel, Pravin
AU  - Patel P
AUID- ORCID: 0000-0002-7598-6121
AD  - Department of Medicine, Cardeza Center for Hemostasis, Thrombosis, and Vascular 
      Biology, Cardeza Foundation for Hematologic Research, Thomas Jefferson 
      University, Philadelphia, PA, USA.
FAU - Naik, Ulhas P
AU  - Naik UP
AUID- ORCID: 0000-0001-7556-444X
AD  - Department of Medicine, Cardeza Center for Hemostasis, Thrombosis, and Vascular 
      Biology, Cardeza Foundation for Hematologic Research, Thomas Jefferson 
      University, Philadelphia, PA, USA.
LA  - eng
GR  - 2R01 HL113188-05/HL/NHLBI NIH HHS/United States
GR  - 2R01 HL113188-05/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20200723
PL  - England
TA  - J Thromb Haemost
JT  - Journal of thrombosis and haemostasis : JTH
JID - 101170508
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - *Blood Platelets/metabolism
MH  - Hemostasis
MH  - Mice
MH  - Mice, Knockout
MH  - *Mitogen-Activated Protein Kinases
MH  - Signal Transduction
OTO - NOTNLM
OT  - MAP kinase signaling system
OT  - blood platelets
OT  - hemostasis
OT  - mitogen-activated protein kinases
OT  - thrombosis
EDAT- 2020/06/24 06:00
MHDA- 2021/05/20 06:00
CRDT- 2020/06/24 06:00
PHST- 2020/05/05 00:00 [received]
PHST- 2020/06/09 00:00 [revised]
PHST- 2020/06/10 00:00 [accepted]
PHST- 2020/06/24 06:00 [pubmed]
PHST- 2021/05/20 06:00 [medline]
PHST- 2020/06/24 06:00 [entrez]
AID - S1538-7836(22)01664-6 [pii]
AID - 10.1111/jth.14967 [doi]
PST - ppublish
SO  - J Thromb Haemost. 2020 Sep;18(9):2087-2102. doi: 10.1111/jth.14967. Epub 2020 Jul 
      23.