PMID- 32574503
OWN - NLM
STAT- MEDLINE
DCOM- 20210817
LR  - 20210817
IS  - 1715-5320 (Electronic)
IS  - 1715-5312 (Linking)
VI  - 45
IP  - 12
DP  - 2020 Dec
TI  - Caloric restriction-induced weight loss with a high-fat diet does not fully 
      recover visceral adipose tissue inflammation in previously obese C57BL/6 mice.
PG  - 1353-1359
LID - 10.1139/apnm-2020-0220 [doi]
AB  - Caloric restriction (CR) reduces body weight and systemic inflammation, but the 
      effects on adipose tissue under dietary lipid overload are controversial. We 
      evaluated the effects of CR-induced weight loss with a high-fat diet on adipose 
      tissue inflammation of obese mice. Male mice were assigned into low-fat diet (LF) 
      and high-fat diet (HF) groups. After 8 weeks, the mice in the HF group were 
      reassigned for another 7 weeks into the following 3 conditions: (i) kept in the 
      HF condition; (ii) changed to low-fat diet ad libitum (LFAL); and (iii) changed 
      to high-fat calorie-restricted (RHF) diet to reach LFAL body weight. Serum 
      markers, adipocytokines, morphology, and inflammatory infiltrates in 
      retroperitoneal adipose tissue (RAT) were accessed. The body weights of the LFAL 
      and RHF groups were reduced, equaling the body weights of the LF group. The LFAL 
      mice had restored almost all inflammatory markers as the LF mice, except tumor 
      necrosis factor-alpha (TNF-alpha), monocyte chemoattractant protein-1 (MCP-1), and 
      adiponectin. Compared with the HF group, the RHF group had lowered visceral 
      adiposity, retroperitoneal adipocyte sizes, and RAT inflammatory cell 
      infiltration, as well as TNF-alpha, interleukin-6, and hepatic and serum C-reactive 
      protein, which were higher than that of the LFAL group; adiponectin and MCP-1 did 
      not change. CR with high-fat diet reduced body weight and attenuated visceral 
      adiposity but did not fully recover visceral tissue inflammation. Novelty Caloric 
      restriction in a high-fat diet ameliorated visceral adiposity. Caloric 
      restriction in a high-fat diet did not recover visceral adipose tissue 
      inflammation.
FAU - Rodrigues, M O M
AU  - Rodrigues MOM
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
FAU - Evangelista-Silva, P H
AU  - Evangelista-Silva PH
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
FAU - Neves, N N
AU  - Neves NN
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
FAU - Moreno, L G
AU  - Moreno LG
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
FAU - Santos, C S
AU  - Santos CS
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
FAU - Rocha, K L S
AU  - Rocha KLS
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
FAU - Ottone, V O
AU  - Ottone VO
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
FAU - Batista-da-Silva, B
AU  - Batista-da-Silva B
AD  - Instituto de Biotecnologia, Universidade Federal de Uberlandia, Uberlandia, MG 
      38408-100, Brazil.
FAU - Dias-Peixoto, M F
AU  - Dias-Peixoto MF
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
FAU - Magalhaes, F C
AU  - Magalhaes FC
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
FAU - Esteves, E A
AU  - Esteves EA
AD  - Programa Multicentrico de Pos-graduacao em Ciencias Fisiologicas, Universidade 
      Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, MG 39100-000, 
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20200623
PL  - Canada
TA  - Appl Physiol Nutr Metab
JT  - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition 
      et metabolisme
JID - 101264333
RN  - 0 (Adipokines)
SB  - IM
MH  - Adipokines
MH  - Adiposity
MH  - Animals
MH  - *Caloric Restriction
MH  - Diet, Fat-Restricted
MH  - *Diet, High-Fat
MH  - Inflammation/*pathology
MH  - Intra-Abdominal Fat/*pathology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Obesity
MH  - *Weight Loss
OTO - NOTNLM
OT  - caloric restriction
OT  - high-fat diet
OT  - inflammation
OT  - obesity
OT  - obesite
OT  - restriction calorique
OT  - regime riche en graisses
OT  - tissu adipeux visceral
OT  - visceral adipose tissue
EDAT- 2020/06/24 06:00
MHDA- 2021/08/18 06:00
CRDT- 2020/06/24 06:00
PHST- 2020/06/24 06:00 [pubmed]
PHST- 2021/08/18 06:00 [medline]
PHST- 2020/06/24 06:00 [entrez]
AID - 10.1139/apnm-2020-0220 [doi]
PST - ppublish
SO  - Appl Physiol Nutr Metab. 2020 Dec;45(12):1353-1359. doi: 10.1139/apnm-2020-0220. 
      Epub 2020 Jun 23.