PMID- 32576160
OWN - NLM
STAT- MEDLINE
DCOM- 20210315
LR  - 20210315
IS  - 1471-2393 (Electronic)
IS  - 1471-2393 (Linking)
VI  - 20
IP  - 1
DP  - 2020 Jun 23
TI  - Real-world in-hospital outcomes and potential predictors of heart failure in 
      primigravid women with heart disease in Southwestern China.
PG  - 372
LID - 10.1186/s12884-020-03058-9 [doi]
LID - 372
AB  - BACKGROUND: Little is known about the status of maternal, obstetric, and neonatal 
      complications and the potential predictors of developing heart failure (HF) in 
      mothers with underlying heart disease (HD) in Southwestern China. METHODS: The 
      eligible records from the YiduCloud database from December 1, 2010 to December 
      31, 2019 were screened. The maternal clinical characteristics and the in-hospital 
      outcomes were collected and compared in primigravid women with and without HD. 
      The HD subtypes analyzed included valvular HD (VHD), cardiomyopathy, adult 
      congenital HD (ACHD), pulmonary hypertension (PH), and other cardiac conditions. 
      RESULTS: Among 45,067 primigravid women, 508 (1.1%) had HD, in which 207 (41%) 
      had ACHD, 66 (13%) had VHD, 84 (17%) had cardiomyopathy, 7 (1%) had PH, and 144 
      (28%) had other cardiac diseases. The maternal cardiac events and the neonatal 
      complications occurred in 28% and 23.3%, respectively, of women with HD and were 
      predominant in the PH group. In multivariable regression, HF was associated with 
      the New York Heart Association (NYHA) class >/=3 (OR = 15.9, 95% confidence 
      interval [CI] = 2.5-99.7; P = 0.003), heart rate >/= 100 bpm (OR = 3.8, 95% 
      CI = 1.1-13.5; P = 0.036), ejection fraction </=60% (OR = 6.4, 95% CI = 2.0-21.0; 
      P = 0.002) and left ventricular end-diastolic diameter >/= 50 mm (OR = 3.4, 95% 
      CI = 1.1-11.2; P = 0.041) at the beginning of pregnancy. CONCLUSIONS: Maternal 
      and neonatal complications are higher in primigravid women with HD particularly 
      in the PH group compared with primigravid women without HD. Women with HD should 
      be guided on the potential predictors for HF and closely monitored during 
      pregnancy to reduce maternal and neonatal complications.
FAU - Wang, Wuwan
AU  - Wang W
AD  - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Wang, Lu
AU  - Wang L
AD  - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Feng, Panpan
AU  - Feng P
AD  - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Liu, Xiyao
AU  - Liu X
AD  - Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Xiang, Rui
AU  - Xiang R
AD  - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Wen, Li
AU  - Wen L
AD  - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Huang, Wei
AU  - Huang W
AD  - Department of Cardiology, The First Affiliated Hospital of Chongqing Medical 
      University, Chongqing, China. weihuangcq@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20200623
PL  - England
TA  - BMC Pregnancy Childbirth
JT  - BMC pregnancy and childbirth
JID - 100967799
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Cardiomyopathies/epidemiology
MH  - China/epidemiology
MH  - Female
MH  - Gravidity
MH  - Heart Defects, Congenital/epidemiology
MH  - Heart Diseases/epidemiology
MH  - Heart Failure/*epidemiology
MH  - Hospitals
MH  - Humans
MH  - Hypertension, Pulmonary/epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/*epidemiology
MH  - Pregnancy Outcome
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Young Adult
PMC - PMC7310540
OTO - NOTNLM
OT  - Cardiac disease
OT  - Pregnancy
OT  - Pulmonary hypertension
OT  - Risk factors
COIS- The authors declare no conflict of interest.
EDAT- 2020/06/25 06:00
MHDA- 2021/03/16 06:00
PMCR- 2020/06/23
CRDT- 2020/06/25 06:00
PHST- 2020/01/23 00:00 [received]
PHST- 2020/06/16 00:00 [accepted]
PHST- 2020/06/25 06:00 [entrez]
PHST- 2020/06/25 06:00 [pubmed]
PHST- 2021/03/16 06:00 [medline]
PHST- 2020/06/23 00:00 [pmc-release]
AID - 10.1186/s12884-020-03058-9 [pii]
AID - 3058 [pii]
AID - 10.1186/s12884-020-03058-9 [doi]
PST - epublish
SO  - BMC Pregnancy Childbirth. 2020 Jun 23;20(1):372. doi: 10.1186/s12884-020-03058-9.