PMID- 32576588
OWN - NLM
STAT- MEDLINE
DCOM- 20210211
LR  - 20240329
IS  - 1790-6245 (Electronic)
IS  - 1109-6535 (Print)
IS  - 1109-6535 (Linking)
VI  - 17
IP  - 4
DP  - 2020 Jul-Aug
TI  - Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide 
      Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma.
PG  - 431-439
LID - 10.21873/cgp.20202 [doi]
AB  - BACKGROUND/AIM: The study aimed to evaluate associations of relative leukocyte 
      telomere length (LTL) and polymorphisms of telomere length-associated genes TERT 
      (rs2736098), TERT-CLPTM1L (rs401681), TRF1 (rs1545827, rs10107605) and TNKS2 
      (rs10509637, rs10509639) in patients with laryngeal squamous cell carcinoma 
      (LSCC). MATERIALS AND METHODS: The study consisted of 300 patients with LSCC and 
      369 healthy control subjects. Genotyping and relative LTL measuring were carried 
      out using qPCR. RESULTS: Relative LTL was statistically significantly shorter in 
      the G3 (tumor differentiation grade) subgroup of patients with LSCC compared to 
      the G1 and G2 subgroups. Significant differences were found in genotype 
      distributions of TERT rs401681 and TNKS2 rs10509639 between the study groups. 
      TERT rs401681 C/T and T/T genotypes were associated with approximately 30% 
      decreased odds of LSCC development. CONCLUSION: LTL was shorter in the G3 
      subgroup compared to the G2 and G1 subgroups of LSCC patients. TERT rs401681 and 
      its C/T and T/T genotypes were associated with decreased odds of overall LSCC 
      development.
CI  - Copyright(c) 2020, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Vaiciulis, Paulius
AU  - Vaiciulis P
AD  - Department of Otorhinolaryngology, Lithuanian University of Health Sciences, 
      Kaunas, Lithuania paulius.vaiciulis@lsmuni.lt.
FAU - Liutkeviciene, Rasa
AU  - Liutkeviciene R
AD  - Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania.
FAU - Liutkevicius, Vykintas
AU  - Liutkevicius V
AD  - Department of Otorhinolaryngology, Lithuanian University of Health Sciences, 
      Kaunas, Lithuania.
FAU - Vilkeviciute, Alvita
AU  - Vilkeviciute A
AD  - Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania.
FAU - Gedvilaite, Greta
AU  - Gedvilaite G
AD  - Neuroscience Institute, Lithuanian University of Health Sciences, Kaunas, 
      Lithuania.
FAU - Uloza, Virgilijus
AU  - Uloza V
AD  - Department of Otorhinolaryngology, Lithuanian University of Health Sciences, 
      Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Cancer Genomics Proteomics
JT  - Cancer genomics & proteomics
JID - 101188791
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Shelterin Complex)
RN  - 0 (TERF1 protein, human)
RN  - 0 (Telomere-Binding Proteins)
RN  - EC 2.4.2.30 (TNKS2 protein, human)
RN  - EC 2.4.2.30 (Tankyrases)
RN  - EC 2.7.7.49 (TERT protein, human)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Biomarkers, Tumor/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - Head and Neck Neoplasms/genetics/pathology
MH  - Humans
MH  - Leukocytes/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Prognosis
MH  - Shelterin Complex
MH  - Squamous Cell Carcinoma of Head and Neck/genetics/*pathology
MH  - Tankyrases/*genetics
MH  - Telomerase/*genetics
MH  - Telomere Homeostasis/*genetics
MH  - Telomere-Binding Proteins/*genetics
PMC - PMC7367600
OTO - NOTNLM
OT  - Leucocyte telomeres
OT  - TERT
OT  - TNKS2
OT  - TRF1
OT  - gene polymorphisms
OT  - laryngeal carcinoma
COIS- The Authors declare no potential conflicts of interest associated with this 
      study.
EDAT- 2020/06/25 06:00
MHDA- 2021/02/12 06:00
PMCR- 2020/07/03
CRDT- 2020/06/25 06:00
PHST- 2020/04/30 00:00 [received]
PHST- 2020/05/09 00:00 [revised]
PHST- 2020/05/14 00:00 [accepted]
PHST- 2020/06/25 06:00 [entrez]
PHST- 2020/06/25 06:00 [pubmed]
PHST- 2021/02/12 06:00 [medline]
PHST- 2020/07/03 00:00 [pmc-release]
AID - 17/4/431 [pii]
AID - 10.21873/cgp.20202 [doi]
PST - ppublish
SO  - Cancer Genomics Proteomics. 2020 Jul-Aug;17(4):431-439. doi: 10.21873/cgp.20202.