PMID- 32576790
OWN - NLM
STAT- MEDLINE
DCOM- 20220107
LR  - 20231003
IS  - 1535-1815 (Electronic)
IS  - 0749-5161 (Linking)
VI  - 38
IP  - 1
DP  - 2022 Jan 1
TI  - Adverse Events Related to Accidental Unintentional Ingestions From Cough and Cold 
      Medications in Children.
PG  - e100-e104
LID - 10.1097/PEC.0000000000002166 [doi]
AB  - OBJECTIVES: Previous research has demonstrated that accidental unsupervised 
      ingestions (AUIs) were responsible for the majority of cough and cold medication 
      (CCM) ingestions leading to significant adverse events (AEs) in children. The 
      objective of this analysis was to characterize the role of AUIs in the morbidity 
      associated with CCM exposure in children. METHODS: This surveillance study 
      collected data from 5 United States data sources from 2009 to 2016, in children 
      younger than 6 years with an AE from an AUI involving at least 1 CCM 
      over-the-counter pharmaceutical ingredient. An expert panel reviewed each case to 
      determine causality. RESULTS: From 4756 total cases reviewed, 3134 (65.9%) had an 
      AE from an AUI determined to be at least potentially related to a CCM ingredient. 
      The majority (61.3%) of cases occurred in children aged 2 to younger than 4 
      years. Most exposures occurred in the child's own residence (94.9%), and 43.8% 
      were admitted to a health care facility (22.0% to a critical care unit). 
      Dextromethorphan and diphenhydramine, when packaged alone or in combination 
      products, contributed to 96.0% of AUIs. The most common specific products 
      involved were single-ingredient pediatric liquid diphenhydramine (30.1%) and 
      single-ingredient pediatric liquid dextromethorphan (21.4%). There were 3 deaths 
      from solid diphenhydramine formulations. CONCLUSIONS: There continues to be 
      opportunities for the implementation of interventions to prevent AUIs of CCM in 
      children. Additional emphasis on engineering controls, such as flow restrictors 
      for liquid formulations targeting diphenhydramine and dextromethorphan products, 
      represent additional opportunities to further reduce AEs from AUIs of CCM.
CI  - Copyright (c) 2020 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Wang, George Sam
AU  - Wang GS
FAU - Reynolds, Kate M
AU  - Reynolds KM
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO.
FAU - Banner, William
AU  - Banner W
AD  - Oklahoma Center for Poison and Drug Information, Oklahoma University College of 
      Pharmacy, Oklahoma City, OK.
FAU - Bond, G Randall
AU  - Bond GR
AD  - Faculte de Medecine, Hope Africa University, Bujumbura, Burundi.
FAU - Kauffman, Ralph E
AU  - Kauffman RE
AD  - Department of Pediatrics, University of Missouri-Kansas City School of Medicine, 
      Kansas City, MO.
FAU - Palmer, Robert B
AU  - Palmer RB
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO.
FAU - Paul, Ian M
AU  - Paul IM
AD  - Pediatrics and Public Health Sciences, Penn State College of Medicine, Hershey, 
      PA.
FAU - Rapp-Olsson, Malin
AU  - Rapp-Olsson M
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO.
FAU - Green, Jody L
AU  - Green JL
FAU - Dart, Richard C
AU  - Dart RC
AD  - Rocky Mountain Poison and Drug Safety, Denver Health and Hospital Authority, 
      Denver, CO.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pediatr Emerg Care
JT  - Pediatric emergency care
JID - 8507560
RN  - 0 (Nonprescription Drugs)
RN  - 8GTS82S83M (Diphenhydramine)
SB  - IM
MH  - Child
MH  - *Cough/chemically induced/epidemiology
MH  - Diphenhydramine
MH  - Eating
MH  - Hospitalization
MH  - Humans
MH  - Infant
MH  - *Nonprescription Drugs/adverse effects
MH  - United States/epidemiology
EDAT- 2020/06/25 06:00
MHDA- 2022/01/08 06:00
CRDT- 2020/06/25 06:00
PHST- 2020/06/25 06:00 [pubmed]
PHST- 2022/01/08 06:00 [medline]
PHST- 2020/06/25 06:00 [entrez]
AID - 00006565-202201000-00036 [pii]
AID - 10.1097/PEC.0000000000002166 [doi]
PST - ppublish
SO  - Pediatr Emerg Care. 2022 Jan 1;38(1):e100-e104. doi: 
      10.1097/PEC.0000000000002166.