PMID- 32577198
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 2042-0188 (Print)
IS  - 2042-0196 (Electronic)
IS  - 2042-0188 (Linking)
VI  - 11
DP  - 2020
TI  - Incidence and risk factors of type 2 diabetes mellitus in individuals with 
      different fasting plasma glucose levels.
PG  - 2042018820928844
LID - 10.1177/2042018820928844 [doi]
LID - 2042018820928844
AB  - OBJECTIVE: Our aim was to examine the incidence and risk factors of type 2 
      diabetes mellitus (T2DM) among individuals with different fasting plasma glucose 
      (FPG) levels. METHODS: According to the first FPG value recorded between January 
      2006 and December 2017, individuals without T2DM (FPG <7 mmol/L) were divided 
      into three groups: normal fasting glucose (NFG, FPG < 5.6 mmol/L), slightly 
      impaired fasting glucose (IFG(low), 5.6 mmol/L ⩽ FPG < 6.1 mmol/L), and severely 
      impaired fasting glucose (IFG(high), 6.1 mmol/L ⩽ FPG < 7.0 mmol/L). Physical 
      examination results, blood biochemical indicators, and questionnaire survey data 
      were collected and the T2DM incidence was examined during the follow-up period. A 
      Cox regression model was used to analyze the T2DM risk factors in the three 
      groups. RESULTS: A total of 44,852 individuals (55.33% men) were included in our 
      study. During the follow-up period (mean follow-up time: 3.73 +/- 0.01 years), 2912 
      T2DM cases occurred. The T2DM incidence rate of the NFG, IFG(low), and IFG(high) 
      groups were 1.5%, 22.2%, and 43.8%, respectively (p < 0.05). In the NFG group, 
      the risk factors for T2DM were older age, overweight, obesity, hypertension, 
      hyperuricemia, and increased estimated glomerular filtration rate (eGFR); the 
      protective factors were female sex and high high-density lipoprotein cholesterol 
      (HDL-C). In the IFG(low) group, the risk factors for T2DM were older age, 
      overweight, obesity, hypertension, and high total cholesterol (TC); the 
      protective factors were increased triglyceride, low-density lipoprotein 
      cholesterol (LDL-C), and HDL-C. In the IFG(high) group, the risk factors for T2DM 
      were older age, obesity, high eGFR, and high TC; the protective factors were 
      female sex, hyperuricemia, high LDL-C, and high HDL-C (all, p < 0.05). 
      CONCLUSIONS: The increased T2DM rates were associated with increased FPG. Risk 
      factors for T2DM vary in the NFG, IFG(low), and IFG(high) groups.
CI  - (c) The Author(s), 2020.
FAU - Han, Yumei
AU  - Han Y
AD  - Beijing Physical Examination Center, Beijing, China.
FAU - Zhang, Shan
AU  - Zhang S
AD  - School of Public Health, Capital Medical University, Beijing, China.
FAU - Chen, Shuo
AU  - Chen S
AD  - Beijing Physical Examination Center, Beijing, China.
FAU - Zhang, Jingbo
AU  - Zhang J
AD  - Beijing Physical Examination Center, Beijing, China.
FAU - Guo, Xiuhua
AU  - Guo X
AD  - School of Public Health, Capital Medical University, Beijing, China.
FAU - Yang, Xinghua
AU  - Yang X
AUID- ORCID: 0000-0001-5608-0255
AD  - School of Public Health, Capital Medical University, 10 Xitoutiao, Youanmen, 
      Fengtai District, Beijing 100069, China.
LA  - eng
PT  - Journal Article
DEP - 20200610
PL  - United States
TA  - Ther Adv Endocrinol Metab
JT  - Therapeutic advances in endocrinology and metabolism
JID - 101532143
PMC - PMC7288838
OTO - NOTNLM
OT  - fasting plasma glucose
OT  - risk factor
OT  - type 2 diabetes mellitus
COIS- Conflict of interest statement: The authors declare that there is no conflict of 
      interest.
EDAT- 2020/06/25 06:00
MHDA- 2020/06/25 06:01
PMCR- 2020/06/10
CRDT- 2020/06/25 06:00
PHST- 2019/12/11 00:00 [received]
PHST- 2020/05/03 00:00 [accepted]
PHST- 2020/06/25 06:00 [entrez]
PHST- 2020/06/25 06:00 [pubmed]
PHST- 2020/06/25 06:01 [medline]
PHST- 2020/06/10 00:00 [pmc-release]
AID - 10.1177_2042018820928844 [pii]
AID - 10.1177/2042018820928844 [doi]
PST - epublish
SO  - Ther Adv Endocrinol Metab. 2020 Jun 10;11:2042018820928844. doi: 
      10.1177/2042018820928844. eCollection 2020.