PMID- 32577996 OWN - NLM STAT- MEDLINE DCOM- 20210827 LR - 20210827 IS - 1699-3055 (Electronic) IS - 1699-048X (Linking) VI - 23 IP - 2 DP - 2021 Feb TI - Expression levels of SCCA and CYFRA 21-1 in serum of patients with laryngeal squamous cell carcinoma and their correlation with tumorigenesis and progression. PG - 289-295 LID - 10.1007/s12094-020-02417-4 [doi] AB - PURPOSE: To explore the concentration of squamous cell carcinoma antigen (SCCA), cytokeratin fragment antigen 21-1 (CYFRA21-1) in patients with laryngeal squamous cell carcinoma (LSCC) and its correlation with tumorigenesis and progression. METHODS: A total of 78 patients with LSCC admitted to our hospital from February 2010 to January 2016 were enrolled as the research group (RG), and another 41 healthy volunteers from the same period were selected as the control group (CG). The serum concentrations of SCCA and CYFRA21-1 in patients with LSCC were detected by ELISA, whose diagnostic value in LSCC were further analyzed by ROC curve. The prognosis and survival curves of patients with LSCC were observed according to the median value of serum SCCA and CYFRA21-1 concentrations. RESULTS: The concentration of CYFRA21-1 and SCCA in the RG was significantly higher than that in the CG (p < 0.050). The SCCA and CYFRA21-1 identified a significant difference in smoking, lymphatic metastasis, TNM staging, and differentiation degree (p < 0.050). The survival rate of the SCCA low-concentration group was significantly better than that of the high-concentration group, p < 0.050. The survival rate of the CYFRA21-1 low-concentration group was markedly better than that of the high-concentration group, p < 0.050. CONCLUSIONS: SCCA and CYFRA21-1 are highly concentrated in LSCC patients, which have good diagnostic efficacy for LSCC. In addition, they play some certain role in the occurrence and development of LSCC, and are expected to be markers for early diagnosis and prognosis of this disease. FAU - Ji, M AU - Ji M AD - Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Kuiwen District, Weifang, 261031, P.R. China. FAU - Zhang, L J AU - Zhang LJ AUID- ORCID: 0000-0001-8013-4073 AD - Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Kuiwen District, Weifang, 261031, P.R. China. u8c2z9@163.com. LA - eng PT - Journal Article DEP - 20200623 PL - Italy TA - Clin Transl Oncol JT - Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico JID - 101247119 RN - 0 (Antigens, Neoplasm) RN - 0 (Biomarkers, Tumor) RN - 0 (Keratin-19) RN - 0 (Serpins) RN - 0 (antigen CYFRA21.1) RN - 0 (squamous cell carcinoma-related antigen) SB - IM MH - Antigens, Neoplasm/*blood MH - Biomarkers, Tumor/blood MH - Carcinogenesis MH - Case-Control Studies MH - Disease Progression MH - Enzyme-Linked Immunosorbent Assay MH - Female MH - Humans MH - Keratin-19/*blood MH - Laryngeal Neoplasms/*blood/etiology/mortality MH - Lymphatic Metastasis MH - Male MH - Middle Aged MH - Neoplasm Staging MH - Prognosis MH - ROC Curve MH - Serpins/*blood MH - Smoking/blood MH - Squamous Cell Carcinoma of Head and Neck/*blood/etiology/mortality MH - Survival Rate OTO - NOTNLM OT - CYFRA21-1 OT - Diagnostic value OT - Laryngeal squamous cell carcinoma OT - Prognosis OT - Squamous cell carcinoma antigen EDAT- 2020/06/25 06:00 MHDA- 2021/08/28 06:00 CRDT- 2020/06/25 06:00 PHST- 2020/02/17 00:00 [received] PHST- 2020/05/28 00:00 [accepted] PHST- 2020/06/25 06:00 [pubmed] PHST- 2021/08/28 06:00 [medline] PHST- 2020/06/25 06:00 [entrez] AID - 10.1007/s12094-020-02417-4 [pii] AID - 10.1007/s12094-020-02417-4 [doi] PST - ppublish SO - Clin Transl Oncol. 2021 Feb;23(2):289-295. doi: 10.1007/s12094-020-02417-4. Epub 2020 Jun 23.