PMID- 32578813
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20220415
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 47
DP  - 2020 Jun 3
TI  - Metabolic and Inflammatory Benefits of Reducing Preoperative Fasting Time in 
      Pediatric Surgery.
PG  - e20202353
LID - S0100-69912020000100153 [pii]
LID - 10.1590/0100-6991e-20202353 [doi]
AB  - OBJECTIVE: To investigate the metabolic/inflammatory impact of reducing the 
      preoperative fasting time in preschool children. METHODS: Forty children were 
      randomly assigned to a fasting group (absolute fasting after 00:00) and a 
      carbohydrate (CHO) group (allowed to ingest, two hours before surgery, a 
      carbohydrate-rich beverage). Blood samples were collected right before and after 
      surgery to quantify the levels of albumin, interleukin-6, glucose, insulin, 
      C-reactive protein and to calculate insulin resistance by the HOMA-IR index. 
      RESULTS: Preoperative fasting time in the CHO group were shorter than in the 
      fasting group (2.49h vs. 11.24h, p <0.001). Pre- and post-surgical CRP levels 
      were significantly lower in the CHO group (p = 0.05 and p = 0.02, respectively). 
      The preoperative CRP/albumin ratios in the CHO group were lower than in the 
      fasting group (p = 0.03). Four patients (21%) in the fasting group but none in 
      the CHO group were hyperglycemic before surgery (p = 0.04). The two groups had 
      similar levels of albumin, interleukin-6, insulin and HOMA index. There were no 
      adverse events. CONCLUSION: Reducing the preoperative fasting time with 
      carbohydrate-rich beverages improves the perioperative metabolic and inflammatory 
      responses of preschool children undergoing inguinal hernia surgery.
FAU - Carvalho, Carlos Augusto Leite de Barros
AU  - Carvalho CALB
AUID- ORCID: 0000-0001-5893-1877
AD  - Santa Casa de Misericordia de Cuiaba-MT, Cirurgia Pediatrica - Cuiaba - MT - 
      Brasil.
FAU - Carvalho, Augusto Aurelio de
AU  - Carvalho AA
AD  - Santa Casa de Misericordia de Cuiaba-MT, Cirurgia Pediatrica - Cuiaba - MT - 
      Brasil.
FAU - Preza, Antonio D'Oliveira Goncalves
AU  - Preza ADG
AD  - Santa Casa de Misericordia de Cuiaba-MT, Cirurgia Pediatrica - Cuiaba - MT - 
      Brasil.
FAU - Nogueira, Paulo Luiz Batista
AU  - Nogueira PLB
AD  - Centro Universitario de Varzea Grande, Faculdade de Medicina - Varzea Grande - MT 
      - Brasil.
FAU - Mendes, Katia Bezerra Veloso
AU  - Mendes KBV
AD  - SEDARE Anestesiologia, Anestesiologia - Cuiaba - MT - Brasil.
FAU - Dock-Nascimento, Diana Borges
AU  - Dock-Nascimento DB
AD  - Universidade Federal de Mato Grosso, Faculdade de Nutricao - Cuiaba - MT - 
      Brasil.
FAU - Aguilar-Nascimento, Jose Eduardo
AU  - Aguilar-Nascimento JE
AD  - Centro Universitario de Varzea Grande, Faculdade de Medicina - Varzea Grande - MT 
      - Brasil.
LA  - por
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
TT  - Beneficios Metabolicos e Inflamatorios da Abreviacao do Jejum Pre-operatorio em 
      Cirurgia Pediatrica.
DEP - 20200603
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Blood Glucose
MH  - C-Reactive Protein
MH  - Child, Preschool
MH  - *Fasting
MH  - Humans
MH  - Insulin
MH  - Insulin Resistance
MH  - Preoperative Care
EDAT- 2020/06/25 06:00
MHDA- 2020/09/01 06:00
CRDT- 2020/06/25 06:00
PHST- 2019/09/17 00:00 [received]
PHST- 2019/11/20 00:00 [accepted]
PHST- 2020/06/25 06:00 [entrez]
PHST- 2020/06/25 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
AID - S0100-69912020000100153 [pii]
AID - 10.1590/0100-6991e-20202353 [doi]
PST - epublish
SO  - Rev Col Bras Cir. 2020 Jun 3;47:e20202353. doi: 10.1590/0100-6991e-20202353.