PMID- 32580192
OWN - NLM
STAT- MEDLINE
DCOM- 20220124
LR  - 20220124
IS  - 1423-0194 (Electronic)
IS  - 0028-3835 (Linking)
VI  - 111
IP  - 7
DP  - 2021
TI  - Pancreatic Neuroendocrine Tumors in Patients with Multiple Endocrine Neoplasia 
      Type 1: Diagnostic Value of Different MRI Sequences.
PG  - 696-704
LID - 10.1159/000509647 [doi]
AB  - BACKGROUND: MRI is a useful imaging modality to assess the presence of pancreatic 
      neuroendocrine tumors (PNETs), allowing repeat monitoring examinations in 
      multiple endocrine neoplasia type 1 (MEN-1) patients. OBJECTIVES: We aimed to 
      compare the diagnostic accuracy of conventional MRI sequences to identify which 
      sequence better depicts the presence of PNETs in MEN-1 patients. METHOD: We 
      performed a retrospective analysis of consecutive MEN-1 patients who underwent a 
      conventional MRI protocol to monitor previously proven PNETs. MRI sequences T1-w 
      chemical shift (CS), T2-w HASTE, fat-suppressed (FS) T2-w HASTE, 
      diffusion-weighted imaging (DWI), and pre- and post-contrast FS T1-w sequences 
      were independently analyzed by 2 experienced radiologists using a 3-grade score 
      (no lesion, uncertain lesion, and certain lesion); lesion size and signal 
      intensity were recorded. A Friedman ANOVA and a Wilcoxon pairwise test for the 
      post hoc analysis were used. The sensitivity of each sequence was measured, and 
      the results were analyzed with the chi2 test. RESULTS: We included 21 patients with 
      a total of 45 PNETs proven by histology, endoscopic ultrasonography-guided 
      fine-needle aspiration, CT, and nuclear medicine studies. A statistically 
      significant (p < 0.01) difference was observed in the detection performance of 
      each MRI sequence, particularly between DWI (91%) and T2-w FS (85%) sequences in 
      comparison to the others (T1-w CS, T2-w, and pre- and post-contrast FS T1-w, </=56% 
      for all); no significant (p = 0.5) difference was found between the detection 
      performance of DWI and T2-w FS sequences. No correlation was observed between the 
      qualitative score of each sequence and lesion tumor size. CONCLUSIONS: DWI and 
      T2-w FS sequences proved to be the most accurate in the detection of PNETs, thus 
      suggesting a role for an abbreviated MRI protocol without contrast medium 
      administration for monitoring MEN-1 patients.
CI  - (c) 2020 S. Karger AG, Basel.
FAU - Verde, Francesco
AU  - Verde F
AD  - Department of Advanced Biomedical Sciences, University of Naples "Federico II,", 
      Naples, Italy.
FAU - Galatola, Roberta
AU  - Galatola R
AD  - Department of Advanced Biomedical Sciences, University of Naples "Federico II,", 
      Naples, Italy.
FAU - Romeo, Valeria
AU  - Romeo V
AD  - Department of Advanced Biomedical Sciences, University of Naples "Federico II,", 
      Naples, Italy, valeria.romeo@unina.it.
FAU - Perillo, Teresa
AU  - Perillo T
AD  - Department of Advanced Biomedical Sciences, University of Naples "Federico II,", 
      Naples, Italy.
FAU - Liuzzi, Raffaele
AU  - Liuzzi R
AD  - Institute of Biostructures and Bioimaging of the National Council of Research 
      (CNR), Naples, Italy.
FAU - Camera, Luigi
AU  - Camera L
AD  - Department of Advanced Biomedical Sciences, University of Naples "Federico II,", 
      Naples, Italy.
FAU - Klain, Michele
AU  - Klain M
AD  - Department of Advanced Biomedical Sciences, University of Naples "Federico II,", 
      Naples, Italy.
FAU - Modica, Roberta
AU  - Modica R
AD  - Department of Clinical Medicine and Surgery, University of Naples "Federico II,", 
      Naples, Italy.
FAU - Faggiano, Antongiulio
AU  - Faggiano A
AD  - Department of Clinical Medicine and Surgery, University of Naples "Federico II,", 
      Naples, Italy.
FAU - Napolitano, Vincenzo
AU  - Napolitano V
AD  - Department of Translational Medical Sciences, University of Campania "L. 
      Vanvitelli,", Naples, Italy.
FAU - Colao, Annamaria
AU  - Colao A
AD  - Department of Clinical Medicine and Surgery, University of Naples "Federico II,", 
      Naples, Italy.
FAU - Brunetti, Arturo
AU  - Brunetti A
AD  - Department of Advanced Biomedical Sciences, University of Naples "Federico II,", 
      Naples, Italy.
FAU - Maurea, Simone
AU  - Maurea S
AD  - Department of Advanced Biomedical Sciences, University of Naples "Federico II,", 
      Naples, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200624
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/methods/*standards
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*diagnostic imaging
MH  - Pancreatic Neoplasms/*diagnostic imaging
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Imaging
OT  - Magnetic resonance imaging
OT  - Multiple endocrine neoplasia type 1
OT  - Pancreas
OT  - Pancreatic neuroendocrine tumors
EDAT- 2020/06/25 06:00
MHDA- 2022/01/27 06:00
CRDT- 2020/06/25 06:00
PHST- 2020/04/22 00:00 [received]
PHST- 2020/06/23 00:00 [accepted]
PHST- 2020/06/25 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2020/06/25 06:00 [entrez]
AID - 000509647 [pii]
AID - 10.1159/000509647 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2021;111(7):696-704. doi: 10.1159/000509647. Epub 2020 Jun 
      24.