PMID- 32581390
OWN - NLM
STAT- MEDLINE
DCOM- 20210708
LR  - 20220503
IS  - 1476-5454 (Electronic)
IS  - 0950-222X (Print)
IS  - 0950-222X (Linking)
VI  - 35
IP  - 5
DP  - 2021 May
TI  - Assessment of retinal neurodegeneration with spectral-domain optical coherence 
      tomography: a systematic review and meta-analysis.
PG  - 1317-1325
LID - 10.1038/s41433-020-1020-z [doi]
AB  - OBJECTIVES: To comprehensively assess diabetic retinopathy neurodegeneration 
      (DRN) as quantified by retinal neuronal and axonal layers measured with 
      spectral-domain optical coherence tomography (SD-OCT) in subjects with diabetes 
      mellitus (DM). METHODS: Articles on the topic of examining macular ganglion 
      cell-inner plexiform layer (m-GCIPL), macular retinal nerve fibre layer (m-RNFL), 
      macular ganglion cell complex (m-GCC), and peripapillary RNFL (p-RNFL) measured 
      with SD-OCT in DM subjects without DR (NDR) or with non-proliferative DR (NPDR) 
      were searched in PubMed and Embase up to November 31, 2019. Standardized mean 
      difference (SMD) as effect size were pooled using random-effects model. RESULTS: 
      Thirty-six studies searched from online databases and the CUHK DM cohort were 
      included in the meta-analysis. In the comparison between NDR and control, macular 
      measures including mean m-GCIPL (SMD = -0.26, p = 0.003), m-RNFL (SMD = -0.26, 
      p = 0.046), and m-GCC (SMD = -0.28; p = 0.009) were significantly thinner in the 
      NDR group. In the comparison between NPDR and NDR, only mean p-RNFL was 
      significantly thinner in the NPDR group (SMD = -0.27; p = 0.03), but not other 
      macular measures. CONCLUSIONS: Thinning of retinal neuronal and axonal layers at 
      macula as measured by SD-OCT are presented in eyes with NDR, supporting DRN may 
      be the early pathogenesis in the DM patients without the presence of clinical 
      signs of DR. In the future, these SD-OCT measures may be used as surrogates of 
      DRN to stratify DM patients with a high risk of DR, and may be used as a 
      therapeutic target if neuroprotection treatment for DR is available.
FAU - Tang, Ziqi
AU  - Tang Z
AUID- ORCID: 0000-0002-4728-0076
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
FAU - Chan, Ming Yan
AU  - Chan MY
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
FAU - Leung, Wai Yin
AU  - Leung WY
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
FAU - Wong, Ho Yeung
AU  - Wong HY
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
FAU - Ng, Ching Man
AU  - Ng CM
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
FAU - Chan, Victor T T
AU  - Chan VTT
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
FAU - Wong, Raymond
AU  - Wong R
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
AD  - Hong Kong Eye Hospital, Hong Kong, SAR, China.
FAU - Lok, Jerry
AU  - Lok J
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
AD  - Hong Kong Eye Hospital, Hong Kong, SAR, China.
FAU - Szeto, Simon
AU  - Szeto S
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
AD  - Hong Kong Eye Hospital, Hong Kong, SAR, China.
FAU - Chan, Jason C K
AU  - Chan JCK
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
AD  - Hong Kong Eye Hospital, Hong Kong, SAR, China.
FAU - Tham, Clement C
AU  - Tham CC
AUID- ORCID: 0000-0003-4407-6907
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China.
AD  - Hong Kong Eye Hospital, Hong Kong, SAR, China.
FAU - Wong, Tien Y
AU  - Wong TY
AD  - Singapore Eye Research Institute, Singapore National Eye Center, Singapore, 
      Singapore.
FAU - Cheung, Carol Y
AU  - Cheung CY
AD  - Department of Ophthalmology and Visual Sciences, The Chinese University of Hong 
      Kong, Hong Kong, SAR, China. carolcheung@cuhk.edu.hk.
LA  - eng
GR  - No. 2017.054/Chinese University of Hong Kong (CUHK)/
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20200624
PL  - England
TA  - Eye (Lond)
JT  - Eye (London, England)
JID - 8703986
SB  - IM
MH  - Humans
MH  - *Macula Lutea/diagnostic imaging
MH  - Nerve Fibers
MH  - Retina
MH  - Retinal Ganglion Cells
MH  - *Tomography, Optical Coherence
PMC - PMC8182828
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/06/26 06:00
MHDA- 2021/07/09 06:00
PMCR- 2022/05/01
CRDT- 2020/06/26 06:00
PHST- 2020/03/13 00:00 [received]
PHST- 2020/06/03 00:00 [accepted]
PHST- 2020/05/28 00:00 [revised]
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2021/07/09 06:00 [medline]
PHST- 2020/06/26 06:00 [entrez]
PHST- 2022/05/01 00:00 [pmc-release]
AID - 10.1038/s41433-020-1020-z [pii]
AID - 1020 [pii]
AID - 10.1038/s41433-020-1020-z [doi]
PST - ppublish
SO  - Eye (Lond). 2021 May;35(5):1317-1325. doi: 10.1038/s41433-020-1020-z. Epub 2020 
      Jun 24.