PMID- 32581580
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 1179-1322 (Print)
IS  - 1179-1322 (Electronic)
IS  - 1179-1322 (Linking)
VI  - 12
DP  - 2020
TI  - Postoperative Concurrent Chemoradiotherapy versus Postoperative Radiotherapy 
      Alone for Larynx Squamous Cell Carcinoma Patients with Lymphovascular Invasion: A 
      Propensity Score Matching Study.
PG  - 4063-4071
LID - 10.2147/CMAR.S250621 [doi]
AB  - PURPOSE: To date, no guidelines have been proposed for the ideal treatment of 
      postoperative larynx squamous cell carcinoma (LSCC) patients with lymphovascular 
      invasion due to a lack of similar studies. The present study was conducted to 
      compare the survival and toxicity in LSCC patients with lymphovascular invasion 
      receiving either postoperative radiotherapy (PORT) or postoperative 
      chemoradiotherapy (POCRT). The results can be applied for more appropriate 
      treatment of these patients. PATIENTS AND METHODS: Three hundred eighty-eight 
      eligible LSCC patients with lymphovascular invasion were enrolled in this 
      retrospective study. Survival and treatment-related toxicities were compared in 
      the POCRT and PORT group using propensity score matching (PSM) methodology (1:1). 
      RESULTS: Five-year overall survival (OS), disease-specific survival (DSS), and 
      recurrence-free survival (RFS) of all patients were 48.7%, 58.2%, and 56.0%, 
      respectively. Significantly, higher RFS rates (P=0.040) were found in the POCRT 
      group than the PORT group in the PSM cohort. In the multivariate analysis, higher 
      OS, DSS, and RFS rates were observed in the POCRT group than the PORT group 
      (P=0.049, 0.024, and 0.011 respectively). Patients in the POCRT group presented 
      more acute toxicities than those in the PORT group such as hematological 
      toxicities (25.0% vs 0.9%, P<0.001) and mucositis (35.0% vs 19.1%, P=0.002). 
      CONCLUSION: In the context of no ideal treatment for LSCC patients with 
      lymphovascular invasion, the present study proposes POCRT as a preferable 
      modality compared with PORT, as POCRT was associated with higher RFS rates. 
      Higher RFS, DFS, and OS rates were also observed in the POCRT group in the 
      multivariate analysis.
CI  - (c) 2020 Yu et al.
FAU - Yu, Shuting
AU  - Yu S
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, People's Republic of China.
FAU - Zhu, Yingying
AU  - Zhu Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, People's Republic of China.
FAU - Shi, Xiaohua
AU  - Shi X
AD  - Department of Pathology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, People's 
      Republic of China.
FAU - Hu, Ke
AU  - Hu K
AD  - Department of Radiotherapy, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, People's 
      Republic of China.
FAU - Bai, Chunmei
AU  - Bai C
AD  - Department of Oncology, Peking Union Medical College Hospital, Peking Union 
      Medical College and Chinese Academy of Medical Sciences, Beijing, People's 
      Republic of China.
FAU - Diao, Wenwen
AU  - Diao W
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, People's Republic of China.
FAU - Zhu, Xiaoli
AU  - Zhu X
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, People's Republic of China.
FAU - Gao, Zhiqiang
AU  - Gao Z
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, People's Republic of China.
FAU - Chen, Xingming
AU  - Chen X
AUID- ORCID: 0000-0002-9930-2185
AD  - Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College 
      Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 
      Beijing, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20200529
PL  - New Zealand
TA  - Cancer Manag Res
JT  - Cancer management and research
JID - 101512700
PMC - PMC7269631
OTO - NOTNLM
OT  - chemoradiotherapy
OT  - head and neck carcinoma
OT  - larynx carcinoma
OT  - lymphovascular invasion
OT  - propensity score
OT  - survival
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/06/26 06:00
MHDA- 2020/06/26 06:01
PMCR- 2020/05/29
CRDT- 2020/06/26 06:00
PHST- 2020/06/26 06:00 [entrez]
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2020/06/26 06:01 [medline]
PHST- 2020/05/29 00:00 [pmc-release]
AID - 250621 [pii]
AID - 10.2147/CMAR.S250621 [doi]
PST - epublish
SO  - Cancer Manag Res. 2020 May 29;12:4063-4071. doi: 10.2147/CMAR.S250621. 
      eCollection 2020.