PMID- 32581697
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231111
IS  - 1662-4548 (Print)
IS  - 1662-453X (Electronic)
IS  - 1662-453X (Linking)
VI  - 14
DP  - 2020
TI  - Persistent Neurovascular Unit Dysfunction: Pathophysiological Substrate and 
      Trigger for Late-Onset Neurodegeneration After Traumatic Brain Injury.
PG  - 581
LID - 10.3389/fnins.2020.00581 [doi]
LID - 581
AB  - Traumatic brain injury (TBI) represents one of the major causes of death 
      worldwide and leads to persisting neurological deficits in many of the survivors. 
      One of the most significant long-term sequelae deriving from TBI is 
      neurodegenerative disease, which is a group of incurable diseases that impose a 
      heavy socio-economic burden. However, mechanisms underlying the increased 
      susceptibility of TBI to neurodegenerative disease remain elusive. The 
      neurovascular unit (NVU) is a functional unit composed of neurons, neuroglia, 
      vascular cells, and the basal lamina matrix. The key role of NVU dysfunction in 
      many central nervous system diseases has been revealed. Studies have proved the 
      presence of prolonged structural and functional abnormalities of the NVU after 
      TBI. Moreover, growing evidence suggests impaired NVU function is also implicated 
      in neurodegenerative diseases. Therefore, we propose the Neurovascular Unit 
      Dysfunction (NVUD) Hypothesis, in which the persistent NVU dysfunction is thought 
      to underlie the development of post-TBI neurodegeneration. We deduce NVUD 
      Hypothesis through relational inference and supporting evidence, and suggest 
      continued NVU abnormalities following TBI serve as the pathophysiological 
      substrate and trigger yielding chronic neuroinflammation, proteinopathies and 
      oxidative stress, consequently leading to the progression of neurodegenerative 
      diseases. The NVUD Hypothesis may provide potential treatment and prevention 
      strategies for TBI and late-onset neurodegenerative diseases.
CI  - Copyright (c) 2020 Zhou, Chen, Wang, Wu, Xu, Pan, Gao, Dong, Zhang and Shao.
FAU - Zhou, Yunxiang
AU  - Zhou Y
AD  - Department of Surgical Oncology, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Chen, Qiang
AU  - Chen Q
AD  - Department of Surgical Oncology, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Wang, Yali
AU  - Wang Y
AD  - Department of Surgical Oncology, The Second Affiliated Hospital, School of 
      Medicine, Zhejiang University, Hangzhou, China.
FAU - Wu, Haijian
AU  - Wu H
AD  - Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, China.
FAU - Xu, Weilin
AU  - Xu W
AD  - Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, China.
FAU - Pan, Yuanbo
AU  - Pan Y
AD  - Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, China.
FAU - Gao, Shiqi
AU  - Gao S
AD  - Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, China.
FAU - Dong, Xiao
AU  - Dong X
AD  - Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, China.
FAU - Zhang, John H
AU  - Zhang JH
AD  - Department of Physiology and Pharmacology, Basic Sciences, School of Medicine, 
      Loma Linda University, Loma Linda, CA, United States.
AD  - Department of Anesthesiology, Neurosurgery and Neurology, School of Medicine, 
      Loma Linda University, Loma Linda, CA, United States.
FAU - Shao, Anwen
AU  - Shao A
AD  - Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine, 
      Zhejiang University, Hangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20200609
PL  - Switzerland
TA  - Front Neurosci
JT  - Frontiers in neuroscience
JID - 101478481
PMC - PMC7296179
OTO - NOTNLM
OT  - blood-brain barrier
OT  - hypothesis
OT  - neurodegenerative disease
OT  - neuroinflammation
OT  - neurovascular unit
OT  - oxidative stress
OT  - proteinopathy
OT  - traumatic brain injury
EDAT- 2020/06/26 06:00
MHDA- 2020/06/26 06:01
PMCR- 2020/01/01
CRDT- 2020/06/26 06:00
PHST- 2020/02/03 00:00 [received]
PHST- 2020/05/12 00:00 [accepted]
PHST- 2020/06/26 06:00 [entrez]
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2020/06/26 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnins.2020.00581 [doi]
PST - epublish
SO  - Front Neurosci. 2020 Jun 9;14:581. doi: 10.3389/fnins.2020.00581. eCollection 
      2020.