PMID- 32581747
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 14
DP  - 2020
TI  - Hemispheric Differences in Functional Interactions Between the Dorsal Lateral 
      Prefrontal Cortex and Ipsilateral Motor Cortex.
PG  - 202
LID - 10.3389/fnhum.2020.00202 [doi]
LID - 202
AB  - Background: The dorsolateral prefrontal cortex (DLPFC) in both hemispheres have a 
      central integrative function for motor control and behavior. Understanding the 
      hemispheric difference between DLPFC and ipsilateral motor cortex connection in 
      the resting-state will provide fundamental knowledge to explain the different 
      roles DLPFC plays in motor behavior. Purpose: The current study tested the 
      interactions between the ipsilateral DLPFC and the primary motor cortex (M1) in 
      each hemisphere at rest. We hypothesized that left DLPFC has a greater inhibitory 
      effect on the ipsilateral M1 compared to the right DLPFC. Methods: Fourteen 
      right-handed subjects were tested in a dual-coil paired-pulse paradigm using 
      transcranial magnetic stimulation. The conditioning stimulus (CS) was applied to 
      the DLPFC and the test stimulus (TS) was applied to M1. Interstimulus intervals 
      (ISIs) between CS and TS were 2, 4, 6, 8, 10, 15, 20, 25, and 30 ms. The result 
      was expressed as a percentage of the mean peak-to-peak amplitude of the 
      unconditioned test pulse. Results: There was stronger inhibitory effect for the 
      left compared to the right hemisphere at ISIs of 2 (p = 0.045), 10 (p = 0.006), 
      15 (p = 0.029) and 20 (p = 0.024) ms. There was no significant inhibition or 
      facilitation at any ISI in the right hemisphere. Conclusions: The two hemispheres 
      have distinct DLPFC and M1 cortico-cortical connectivity at rest. Left hemisphere 
      DLPFC is dominant in inhibiting ipsilateral M1.
CI  - Copyright (c) 2020 Wang, Cao, Lin, Chen and Zhang.
FAU - Wang, Yanqiu
AU  - Wang Y
AD  - School of Psychology, Shanghai University of Sport, Shanghai, China.
AD  - Krembil Research Institute, University Health Network, Toronto, ON, Canada.
AD  - Division of Neurology, Department of Medicine, University of Toronto, Toronto, 
      ON, Canada.
FAU - Cao, Na
AU  - Cao N
AD  - School of Psychology, Shanghai University of Sport, Shanghai, China.
AD  - Department of Life Sciences, Graduate School of Arts and Sciences, University of 
      Tokyo, Tokyo, Japan.
FAU - Lin, Yitong
AU  - Lin Y
AD  - School of Psychology, Shanghai University of Sport, Shanghai, China.
FAU - Chen, Robert
AU  - Chen R
AD  - Krembil Research Institute, University Health Network, Toronto, ON, Canada.
AD  - Division of Neurology, Department of Medicine, University of Toronto, Toronto, 
      ON, Canada.
FAU - Zhang, Jian
AU  - Zhang J
AD  - School of Psychology, Shanghai University of Sport, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20200603
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC7283611
OTO - NOTNLM
OT  - dorsolateral prefrontal cortex
OT  - functional connectivity
OT  - hemispheric differences
OT  - primary motor cortex
OT  - transcranial magnetic stimulation
EDAT- 2020/06/26 06:00
MHDA- 2020/06/26 06:01
PMCR- 2020/01/01
CRDT- 2020/06/26 06:00
PHST- 2019/12/02 00:00 [received]
PHST- 2020/05/05 00:00 [accepted]
PHST- 2020/06/26 06:00 [entrez]
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2020/06/26 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2020.00202 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2020 Jun 3;14:202. doi: 10.3389/fnhum.2020.00202. eCollection 
      2020.