PMID- 32581841
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 1664-042X (Print)
IS  - 1664-042X (Electronic)
IS  - 1664-042X (Linking)
VI  - 11
DP  - 2020
TI  - Dysregulated Neurovascular Control Underlies Declining Microvascular 
      Functionality in People With Non-alcoholic Fatty Liver Disease (NAFLD) at Risk of 
      Liver Fibrosis.
PG  - 551
LID - 10.3389/fphys.2020.00551 [doi]
LID - 551
AB  - BACKGROUND/AIMS: Increasing evidence shows that non-alcoholic fatty liver disease 
      (NAFLD) is associated with dysregulation of microvascular perfusion independently 
      of established cardio-metabolic risk factors. We investigated whether hepatic 
      manifestations of NAFLD such as liver fibrosis and liver fat are associated with 
      microvascular hemodynamics through dysregulation of neurovascular control. 
      METHODS: Microvascular dilator (post-occlusive reactive hyperemia) and 
      sympathetically mediated constrictor (deep inspiratory breath-hold) responses 
      were measured at the forearm and finger, respectively, using laser Doppler 
      fluximetry. Non-linear complexity-based analysis was used to assess the 
      information content and variability of the resting blood flux (BF) signals, 
      attributable to oscillatory flow-motion activity, and over multiple sampling 
      frequencies. RESULTS: Measurements were made in 189 adults (113 men) with NAFLD, 
      with (n = 65) and without (n = 124) type 2 diabetes mellitus (T2DM), age = 50.9 +/- 
      11.7 years (mean +/- SD). Microvascular dilator and constrictor capacity were both 
      negatively associated with age (r = -0.178, p = 0.014, and r = -0.201, p = 0.007, 
      respectively) and enhanced liver fibrosis (ELF) score (r = -0.155, p = 0.038 and 
      r = -0.418, p < 0.0001, respectively). There was no association with measures of 
      liver fat, obesity or T2DM. Lempel-Ziv complexity (LZC) and sample entropy (SE) 
      of the BF signal measured at the two skin sites were associated negatively with 
      age (p < 0.01 and p < 0.001) and positively with ELF score (p < 0.05 and p < 
      0.0001). In individuals with an ELF score >/=7.8 the influence of both neurogenic 
      and respiratory flow-motion activity on LZC was up-rated (p < 0.0001). 
      CONCLUSION: Altered microvascular network functionality occurs in adults with 
      NAFLD suggesting a mechanistic role for dysregulated neurovascular control in 
      individuals at risk of severe liver fibrosis.
CI  - Copyright (c) 2020 Clough, Chipperfield, Thanaj, Scorletti, Calder and Byrne.
FAU - Clough, Geraldine F
AU  - Clough GF
AD  - Human Development and Health, Faculty of Medicine, University of Southampton, 
      Southampton, United Kingdom.
FAU - Chipperfield, Andrew J
AU  - Chipperfield AJ
AD  - Faculty of Engineering and Physical Sciences, University of Southampton, 
      Southampton, United Kingdom.
FAU - Thanaj, Marjola
AU  - Thanaj M
AD  - Faculty of Engineering and Physical Sciences, University of Southampton, 
      Southampton, United Kingdom.
FAU - Scorletti, Eleonora
AU  - Scorletti E
AD  - Human Development and Health, Faculty of Medicine, University of Southampton, 
      Southampton, United Kingdom.
AD  - National Institute for Health Research Southampton Biomedical Research Centre, 
      University of Southampton, University Hospital Southampton National Health 
      Service Foundation Trust, Southampton, United Kingdom.
AD  - Department of Gastroenterology, Perelman School of Medicine, University of 
      Pennsylvania, Philadelphia, PA, United States.
FAU - Calder, Philip C
AU  - Calder PC
AD  - Human Development and Health, Faculty of Medicine, University of Southampton, 
      Southampton, United Kingdom.
AD  - National Institute for Health Research Southampton Biomedical Research Centre, 
      University of Southampton, University Hospital Southampton National Health 
      Service Foundation Trust, Southampton, United Kingdom.
FAU - Byrne, Christopher D
AU  - Byrne CD
AD  - Human Development and Health, Faculty of Medicine, University of Southampton, 
      Southampton, United Kingdom.
AD  - National Institute for Health Research Southampton Biomedical Research Centre, 
      University of Southampton, University Hospital Southampton National Health 
      Service Foundation Trust, Southampton, United Kingdom.
LA  - eng
PT  - Journal Article
DEP - 20200603
PL  - Switzerland
TA  - Front Physiol
JT  - Frontiers in physiology
JID - 101549006
PMC - PMC7283580
OTO - NOTNLM
OT  - NAFLD
OT  - blood flow
OT  - flow-motion
OT  - liver fibrosis
OT  - microcirculation
OT  - non-linear complexity analysis
OT  - skin
OT  - sympathetic nervous system
EDAT- 2020/06/26 06:00
MHDA- 2020/06/26 06:01
PMCR- 2020/06/03
CRDT- 2020/06/26 06:00
PHST- 2020/03/16 00:00 [received]
PHST- 2020/04/30 00:00 [accepted]
PHST- 2020/06/26 06:00 [entrez]
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2020/06/26 06:01 [medline]
PHST- 2020/06/03 00:00 [pmc-release]
AID - 10.3389/fphys.2020.00551 [doi]
PST - epublish
SO  - Front Physiol. 2020 Jun 3;11:551. doi: 10.3389/fphys.2020.00551. eCollection 
      2020.