PMID- 32582017
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 1664-2295 (Print)
IS  - 1664-2295 (Electronic)
IS  - 1664-2295 (Linking)
VI  - 11
DP  - 2020
TI  - Retinal Changes After Posterior Cerebral Artery Infarctions Display Different 
      Patterns of the Nasal und Temporal Sector in a Case Series.
PG  - 508
LID - 10.3389/fneur.2020.00508 [doi]
LID - 508
AB  - Background: Visual field defects are a common and disabling consequence of stroke 
      and a negative prognostic factor of patient's quality of life. They result from 
      lesions in different parts of the visual system, most commonly the visual cortex 
      and optic radiation. An important pathophysiological mechanism is transsynaptic 
      retrograde degeneration (TRD). Methods: In a case series 21 patients with 
      posterior cerebral artery (PCA) territory infarctions were analyzed by 
      spectral-domain optical coherence tomography (SD-OCT) and multifocal visual 
      evoked potentials (mfVEPs) cross-sectionally and longitudinally for up to 6 
      months. In OCT, symptomatic affected nasal and temporal sectors and corresponding 
      visual fields in mfVEPs were compared to the contralateral side. Results: SD-OCT 
      revealed a significant reduction (-2.92 +/-2.53 mum, mean +/- SD) of the symptomatic 
      nasal macular retinal nerve fiber layer (RNFL) thickness and of the symptomatic 
      temporal peripapillary RNFL after 6 months compared to baseline whereas the 
      symptomatic temporal macular quadrant already showed a significantly thinner RNFL 
      at baseline. The mfVEP first peak latency at baseline was significantly different 
      (nasal visual field +11.69 +/-11.17 ms, mean +/- SD; temporal visual field +16.63 
      +/-7.97 ms, mean +/- SD) on the symptomatic compared to the asymptomatic field. The 
      nasal visual fields partly recovered in amplitude and first peak latency of 
      mfVEPs over the following 6 months compared to baseline. Conclusion: The dynamics 
      of OCT and mfVEP outcomes for degeneration and recovery after PCA infarction 
      differ between the nasal and temporal retinal sector. We postulate that retinal 
      sectors may differ in their temporal pattern of TRD over time after 
      retrogeniculate cerebral infarction.
CI  - Copyright (c) 2020 Lee, Boerker, Gemerzki, Harmel, Guthoff, Aktas, Gliem, Jander, 
      Hartung and Albrecht.
FAU - Lee, John-Ih
AU  - Lee JI
AD  - Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, 
      Germany.
FAU - Boerker, Laura
AU  - Boerker L
AD  - Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, 
      Germany.
FAU - Gemerzki, Lena
AU  - Gemerzki L
AD  - Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, 
      Germany.
FAU - Harmel, Jens
AU  - Harmel J
AD  - Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, 
      Germany.
FAU - Guthoff, Rainer
AU  - Guthoff R
AD  - Department of Ophthalmology, Medical Faculty, Heinrich-Heine-University, 
      Duesseldorf, Germany.
FAU - Aktas, Orhan
AU  - Aktas O
AD  - Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, 
      Germany.
FAU - Gliem, Michael
AU  - Gliem M
AD  - Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, 
      Germany.
FAU - Jander, Sebastian
AU  - Jander S
AD  - Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, 
      Germany.
FAU - Hartung, Hans-Peter
AU  - Hartung HP
AD  - Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, 
      Germany.
FAU - Albrecht, Philipp
AU  - Albrecht P
AD  - Department of Neurology, Medical Faculty, Heinrich-Heine-University, Duesseldorf, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20200605
PL  - Switzerland
TA  - Front Neurol
JT  - Frontiers in neurology
JID - 101546899
PMC - PMC7290045
OTO - NOTNLM
OT  - ischemic stroke
OT  - multifocal visual evoked potential
OT  - optical coherence tomography
OT  - posterior cerebral artery infarction
OT  - retinal layer
EDAT- 2020/06/26 06:00
MHDA- 2020/06/26 06:01
PMCR- 2020/06/05
CRDT- 2020/06/26 06:00
PHST- 2019/10/28 00:00 [received]
PHST- 2020/05/07 00:00 [accepted]
PHST- 2020/06/26 06:00 [entrez]
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2020/06/26 06:01 [medline]
PHST- 2020/06/05 00:00 [pmc-release]
AID - 10.3389/fneur.2020.00508 [doi]
PST - epublish
SO  - Front Neurol. 2020 Jun 5;11:508. doi: 10.3389/fneur.2020.00508. eCollection 2020.