PMID- 32583214
OWN - NLM
STAT- MEDLINE
DCOM- 20210414
LR  - 20210414
IS  - 1618-2650 (Electronic)
IS  - 1618-2642 (Print)
IS  - 1618-2642 (Linking)
VI  - 412
IP  - 22
DP  - 2020 Sep
TI  - Development and validation of a multi-analyte GC-MS method for the determination 
      of 84 substances from plastic food contact materials.
PG  - 5419-5434
LID - 10.1007/s00216-020-02758-7 [doi]
AB  - Chemical substances shall not migrate from food contact materials (FCM) at levels 
      that are potentially harmful for the consumers. Each of the current analytical 
      methods applied to verify the migration of substances from FCM covers only one or 
      few substances. There is a very limited number of publications on the development 
      of analytical methods allowing the simultaneous determination of several classes 
      of FCM substances, and almost none of them reported methods entirely dedicated to 
      the ones in the positive list of Commission Regulation (EU) No. 10/2011 for 
      plastic FCMs. Therefore, a simple, sensitive and reliable multi-analyte method 
      was developed for the analysis of FCM substances in food simulants. It employs an 
      optimised liquid-liquid extraction with dichloromethane as extraction solvent in 
      the presence of 10% m/v NaCl, followed by quantitative analysis with gas 
      chromatography coupled to mass spectrometry (GC-MS). A combination of total ion 
      chromatograms (TICs) and extracted ion chromatograms (EICs) was used. The 
      optimisation and validation of the method have been carried out according to 
      current international guidelines. Adequate sensitivity was demonstrated in the 
      selected concentration ranges for most of the analytes, with limits of 
      quantification (LOQs) at least three times lower than the legislative limit, when 
      existing. The results showed that the method is sufficiently accurate for the 
      majority of substances, with recoveries between 70 and 115% and relative standard 
      deviations (RSDs) smaller than 20% at three concentration levels. The method was 
      applied to the analysis of some FCM multilayers. The method allows, for the first 
      time, the simultaneous quantification of 84 FCM substances in two of the official 
      food simulants (A and C) at levels of a few ng g(-1). Graphical abstract.
FAU - Tsochatzis, Emmanouil D
AU  - Tsochatzis ED
AD  - European Commission, Joint Research Centre (JRC), Retieseweg 111, 2440, Geel, 
      Belgium.
FAU - Alberto Lopes, Joao
AU  - Alberto Lopes J
AD  - European Commission, Joint Research Centre (JRC), Retieseweg 111, 2440, Geel, 
      Belgium. joao-filipe.alberto-lopes@ec.europa.eu.
FAU - Hoekstra, Eddo
AU  - Hoekstra E
AD  - European Commission, Joint Research Centre (JRC), Via E. Fermi 2749, 21027, 
      Ispra, Italy.
FAU - Emons, Hendrik
AU  - Emons H
AD  - European Commission, Joint Research Centre (JRC), Retieseweg 111, 2440, Geel, 
      Belgium.
LA  - eng
PT  - Journal Article
PT  - Validation Study
DEP - 20200624
PL  - Germany
TA  - Anal Bioanal Chem
JT  - Analytical and bioanalytical chemistry
JID - 101134327
RN  - 0 (Plastics)
SB  - IM
MH  - Dietary Exposure
MH  - Food Contamination/*analysis
MH  - *Food Packaging
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Humans
MH  - Limit of Detection
MH  - Liquid-Liquid Extraction
MH  - Plastics/*analysis
PMC - PMC7387375
OTO - NOTNLM
OT  - Food contact materials
OT  - GC-MS
OT  - Migration into food simulants
OT  - Multi-analyte method
OT  - Substances migrating from plastic food packaging
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/06/26 06:00
MHDA- 2021/04/15 06:00
PMCR- 2020/06/24
CRDT- 2020/06/26 06:00
PHST- 2020/04/27 00:00 [received]
PHST- 2020/06/04 00:00 [accepted]
PHST- 2020/05/28 00:00 [revised]
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2021/04/15 06:00 [medline]
PHST- 2020/06/26 06:00 [entrez]
PHST- 2020/06/24 00:00 [pmc-release]
AID - 10.1007/s00216-020-02758-7 [pii]
AID - 2758 [pii]
AID - 10.1007/s00216-020-02758-7 [doi]
PST - ppublish
SO  - Anal Bioanal Chem. 2020 Sep;412(22):5419-5434. doi: 10.1007/s00216-020-02758-7. 
      Epub 2020 Jun 24.