PMID- 32584032
OWN - NLM
STAT- MEDLINE
DCOM- 20210118
LR  - 20210118
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 68
IP  - 29
DP  - 2020 Jul 22
TI  - Toxicokinetic Studies in Piglets Reveal Age-Related Differences in Systemic 
      Exposure to Zearalenone, Zearalenone-14-Glucoside, and Zearalenone-14-Sulfate.
PG  - 7757-7764
LID - 10.1021/acs.jafc.0c01943 [doi]
AB  - Juveniles are considered as one of the most vulnerable population groups 
      concerning mycotoxins and their modified forms. The weaning stage is a 
      particularly vulnerable period in the life of mammals, reflected in intestinal 
      and immune dysfunction. The current study investigated the toxicokinetic (TK) 
      characteristics of zearalenone (ZEN), zearalenone-14-glucoside (ZEN14G), and 
      zearalenone-14-sulfate (ZEN14S) in weaned (4-week-old) piglets, by means of oral 
      and intravenous administration of equimolar doses, i.e., 331, 500, and 415 mug/kg 
      bodyweight, respectively. Plasma and urine were sampled pre- and 
      post-administration and were quantitatively analyzed for ZEN, ZEN14G, ZEN14S, and 
      in vivo metabolites by liquid chromatography-high-resolution mass spectrometry. 
      Tailor-made TK models were elaborated to process data. A statistical comparison 
      of the results was performed with TK data obtained in a previously reported study 
      in pigs of 8 weeks of age. Additionally, porcine plasma protein binding was 
      determined to support TK findings. The TK results for ZEN, ZEN14G, and ZEN14S, 
      obtained in 4- and 8-week-old pigs, revealed significant age-related differences, 
      based on differences in intestinal permeability, body fat content, 
      gastrointestinal transit time, and biotransformation, with a special emphasis on 
      an increased absorbed fraction of ZEN14G, i.e., 94 vs 61% in 4- compared to 
      8-week-old pigs. Since the growing pig has been reported to be a suitable 
      pediatric animal model for humans concerning TK processes, these results may 
      contribute to refine the risk assessment concerning modified ZEN forms in 
      juvenile animals and humans.
FAU - Catteuw, Amelie
AU  - Catteuw A
AUID- ORCID: 0000-0001-8463-2184
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
FAU - Devreese, Mathias
AU  - Devreese M
AUID- ORCID: 0000-0003-2512-4176
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
FAU - De Baere, Siegrid
AU  - De Baere S
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
FAU - Antonissen, Gunther
AU  - Antonissen G
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
AD  - Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary 
      Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
FAU - Huybrechts, Bart
AU  - Huybrechts B
AD  - Sciensano, Juliette Wytsmanstraat 14, 1050 Elsene, Belgium.
FAU - Ivanova, Lada
AU  - Ivanova L
AD  - Toxinology Research Group, Norwegian Veterinary Institute, Ullevalsveien 68, 0454 
      Oslo, Norway.
FAU - Uhlig, Silvio
AU  - Uhlig S
AUID- ORCID: 0000-0001-6419-9563
AD  - Toxinology Research Group, Norwegian Veterinary Institute, Ullevalsveien 68, 0454 
      Oslo, Norway.
FAU - Martens, Ann
AU  - Martens A
AD  - Department of Surgery and Anaesthesiology of Domestic Animals, Faculty of 
      Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, 
      Belgium.
FAU - De Saeger, Sarah
AU  - De Saeger S
AUID- ORCID: 0000-0002-2160-7253
AD  - Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, 
      Ottergemsesteenweg 460, 9000 Ghent, Belgium.
FAU - De Boevre, Marthe
AU  - De Boevre M
AUID- ORCID: 0000-0002-6151-5126
AD  - Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, 
      Ottergemsesteenweg 460, 9000 Ghent, Belgium.
FAU - Croubels, Siska
AU  - Croubels S
AUID- ORCID: 0000-0001-6357-3517
AD  - Department of Pharmacology, Toxicology and Biochemistry, Faculty of Veterinary 
      Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
LA  - eng
PT  - Journal Article
DEP - 20200709
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Glucosides)
RN  - 0 (Sulfates)
RN  - 0 (zearalenone-14-glucoside)
RN  - 5W827M159J (Zearalenone)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Female
MH  - Glucosides/blood/*pharmacokinetics/toxicity/urine
MH  - Male
MH  - Sulfates/blood/toxicity/urine
MH  - Swine/*blood/growth & development/*urine
MH  - Toxicokinetics
MH  - Zearalenone/*analogs & derivatives/blood/*pharmacokinetics/toxicity/urine
OTO - NOTNLM
OT  - pig
OT  - toxicokinetics
OT  - weaning
OT  - zearalenone
OT  - zearalenone-14-glucoside
OT  - zearalenone-14-sulfate
EDAT- 2020/06/26 06:00
MHDA- 2021/01/20 06:00
CRDT- 2020/06/26 06:00
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2021/01/20 06:00 [medline]
PHST- 2020/06/26 06:00 [entrez]
AID - 10.1021/acs.jafc.0c01943 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2020 Jul 22;68(29):7757-7764. doi: 10.1021/acs.jafc.0c01943. 
      Epub 2020 Jul 9.