PMID- 32584132
OWN - NLM
STAT- MEDLINE
DCOM- 20210708
LR  - 20220210
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Print)
IS  - 0862-8408 (Linking)
VI  - 69
IP  - 4
DP  - 2020 Aug 31
TI  - Wnt/beta-Catenin Signaling Contributes to Vincristine-Induced Neuropathic Pain.
PG  - 701-710
AB  - Chemotherapy-induced neuropathic pain (CNP) is the major dose-limiting factor in 
      cancer chemotherapy. However, the mechanisms underlying CNP remain elusive. In 
      the present study, CNP was induced by repeated intraperitoneal injection of 
      vincristine (VCR) into male C57BL/6J mice. VCR administration caused significant 
      activation of Wnt/beta-catenin signaling, which led to the activation of 
      astrocytes, microglia, the release of inflammatory cytokines tumour necrosis 
      factor (TNF)-alpha, monocyte chemoattractant protein-1 (MCP-1) and the activation 
      of subsequent mitogen-activated protein kinase (MAPK)/extracellular 
      signal-regulated protein kinase (ERK) signaling pathway in CNP mice. Blocking 
      Wnt/beta-catenin signaling by intrathecal administration of the inhibitors of Wnt 
      response (IWR) effectively attenuated VCR-induced neuropathic pain. Furthermore, 
      IWR inhibited the activation of astrocytes, microglia, TNF-alpha, MCP-1 and 
      MAPK/ERK signaling in the spinal cord, which was triggered by VCR-induced 
      Wnt/beta-catenin signaling upregulation. These results suggest that 
      Wnt/beta-catenin signaling plays a critical role in VCR-induced neuropathic pain 
      and provides evidence for potential interfering with Wnt/beta-catenin signaling 
      to ameliorate VCR-induced neuropathic pain.
FAU - Hu, C
AU  - Hu C
AD  - Department of Bioengineering, College of Food Science, Guangdong Ocean 
      University, Zhanjiang, Guangdong, China. liuy6254282@163.com, College of 
      Agriculture, Guangdong Ocean University, Zhanjiang, Guangdong, China. 
      lyf201809@163.com.
FAU - Zhao, Y-T
AU  - Zhao YT
FAU - Cui, Y-B
AU  - Cui YB
FAU - Zhang, H-H
AU  - Zhang HH
FAU - Huang, G-L
AU  - Huang GL
FAU - Liu, Y
AU  - Liu Y
FAU - Liu, Y-F
AU  - Liu YF
LA  - eng
PT  - Journal Article
DEP - 20200625
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 0 (CTNNB1 protein, mouse)
RN  - 0 (Wnt Proteins)
RN  - 0 (beta Catenin)
RN  - 5J49Q6B70F (Vincristine)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents, Phytogenic/adverse effects/pharmacology
MH  - Disease Models, Animal
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neoplasms/*drug therapy/metabolism/pathology
MH  - Neuralgia/chemically induced/metabolism/*pathology
MH  - Signal Transduction
MH  - Vincristine/*adverse effects/pharmacology
MH  - Wnt Proteins/*metabolism
MH  - *Wnt Signaling Pathway
MH  - beta Catenin/*metabolism
PMC - PMC8549884
COIS- Conflict of Interest There is no conflict of interest.
EDAT- 2020/06/26 06:00
MHDA- 2021/07/09 06:00
PMCR- 2020/06/25
CRDT- 2020/06/26 06:00
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2021/07/09 06:00 [medline]
PHST- 2020/06/26 06:00 [entrez]
PHST- 2020/06/25 00:00 [pmc-release]
AID - 934314 [pii]
AID - pr69_701 [pii]
AID - 10.33549/physiolres.934314 [doi]
PST - ppublish
SO  - Physiol Res. 2020 Aug 31;69(4):701-710. doi: 10.33549/physiolres.934314. Epub 
      2020 Jun 25.