PMID- 32584136
OWN - NLM
STAT- MEDLINE
DCOM- 20210708
LR  - 20220210
IS  - 1802-9973 (Electronic)
IS  - 0862-8408 (Print)
IS  - 0862-8408 (Linking)
VI  - 69
IP  - 4
DP  - 2020 Aug 31
TI  - Increasing Veno-Arterial Extracorporeal Membrane Oxygenation Flow Reduces 
      Electrical Impedance of the Lung Regions in Porcine Acute Heart Failure.
PG  - 609-620
AB  - Veno-arterial extracorporeal membrane oxygenation (VA ECMO) is a technique used 
      in patients with severe heart failure. The aim of this study was to evaluate its 
      effects on left ventricular afterload and fluid accumulation in lungs with 
      electrical impedance tomography (EIT). In eight swine, incremental increases of 
      extracorporeal blood flow (EBF) were applied before and after the induction of 
      ischemic heart failure. Hemodynamic parameters were continuously recorded and 
      computational analysis of EIT was used to determine lung fluid accumulation. With 
      an increase in EBF from 1 to 4 l/min in acute heart failure the associated 
      increase of arterial pressure (raised by 44%) was accompanied with significant 
      decrease of electrical impedance of lung regions. Increasing EBF in healthy 
      circulation did not cause lung impedance changes. Our findings indicate that in 
      severe heart failure EIT may reflect fluid accumulation in lungs due to 
      increasing EBF.
FAU - Popkova, M
AU  - Popkova M
AD  - Department of Physiology, First Faculty of Medicine, Charles University, Prague, 
      Czech Republic. mikulas.mlcek@lf1.cuni.cz.
FAU - Kuriscak, E
AU  - Kuriscak E
FAU - Hala, P
AU  - Hala P
FAU - Janak, D
AU  - Janak D
FAU - Tejkl, L
AU  - Tejkl L
FAU - Belohlavek, J
AU  - Belohlavek J
FAU - Ostadal, P
AU  - Ostadal P
FAU - Neuzil, P
AU  - Neuzil P
FAU - Kittnar, O
AU  - Kittnar O
FAU - Mlcek, M
AU  - Mlcek M
LA  - eng
PT  - Journal Article
DEP - 20200625
PL  - Czech Republic
TA  - Physiol Res
JT  - Physiological research
JID - 9112413
SB  - IM
MH  - Animals
MH  - Coronary Circulation/physiology
MH  - Disease Models, Animal
MH  - Electric Impedance
MH  - Extracorporeal Membrane Oxygenation/adverse effects/*methods
MH  - Female
MH  - Heart Failure/metabolism/pathology/*therapy
MH  - Hemodynamics
MH  - Lung/*physiopathology
MH  - Respiratory Insufficiency/etiology/*pathology
MH  - Swine
PMC - PMC8549886
COIS- Conflict of Interest There is no conflict of interest.
EDAT- 2020/06/26 06:00
MHDA- 2021/07/09 06:00
PMCR- 2020/06/25
CRDT- 2020/06/26 06:00
PHST- 2020/06/26 06:00 [pubmed]
PHST- 2021/07/09 06:00 [medline]
PHST- 2020/06/26 06:00 [entrez]
PHST- 2020/06/25 00:00 [pmc-release]
AID - 934429 [pii]
AID - pr69_609 [pii]
AID - 10.33549/physiolres.934429 [doi]
PST - ppublish
SO  - Physiol Res. 2020 Aug 31;69(4):609-620. doi: 10.33549/physiolres.934429. Epub 
      2020 Jun 25.