PMID- 3258434
OWN - NLM
STAT- MEDLINE
DCOM- 19880505
LR  - 20151119
IS  - 0034-5164 (Print)
IS  - 0034-5164 (Linking)
VI  - 59
IP  - 1
DP  - 1988 Jan
TI  - Toxicity of citreoviridin.
PG  - 31-52
AB  - The mycotoxin citreoviridin (CIT) isolated from Penicillium citreoviride was 
      studied to elucidate the mechanism of its toxic actions. In CF#1 mice, near 
      lethal doses of CIT decreased motor activities, body temperature and had 
      cataleptic effects. Male mice appeared to be more susceptible to CIT and had 
      lower subcutaneous (sc) LD50 values and longer CIT-induced hypothermia and 
      hypokinesia. In CIT-treated mice the weights and histology of liver, kidneys and 
      adrenals were normal one week after sc treatment, except for the increased 
      adrenal weights in female mice. Single doses of CIT (sc), given on either day 4 
      or 5 of pregnancy (perinidation period), had no adverse effect on the rates of 
      pregnancy, implantation of ova and embryonal resorptions in those mice examined 
      on day 12 of pregnancy. CIT (40 mg/kg ip) produced a brief 
      electro-encephalographic (EEG) activation, cardiac sinus arrhythmias and 
      tachypnea in the rabbit. Intravenous (iv) lethal doses of CIT (greater than or 
      equal to 5 mg/kg) caused an EEG activation followed by high voltage delta waves, 
      increased the T wave in the electrocardiogram (ECG) and depressed the respiratory 
      amplitude. The death caused by iv CIT started with the respiratory arrest, 
      followed by isoelectric EEG and ECG was the last to stop. In 
      urethane-anesthetized rabbits CIT decreased the blood pressure, and in succession 
      it lowered, flattened and inverted the T wave of ECG suggesting heart ischemia. 
      These observations indicated that the toxic effects of CIT resulted from 
      respiratory and cardiovascular failures (apnea, delta EEG waves, sinus 
      arrhythmia, hypotension) leading to central nervous system depression due to 
      systemic hypoxia.
FAU - Nishie, K
AU  - Nishie K
AD  - U. S. Department of Agriculture, R. B. Russell Agricultural Research Center, 
      Athens, GA 30613.
FAU - Cole, R J
AU  - Cole RJ
FAU - Dorner, J W
AU  - Dorner JW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Res Commun Chem Pathol Pharmacol
JT  - Research communications in chemical pathology and pharmacology
JID - 0244734
RN  - 0 (Aurovertins)
RN  - 0 (Mycotoxins)
RN  - 0 (Pyrans)
RN  - OWX7Q6CF4F (citreoviridin)
SB  - IM
MH  - Adrenal Glands/drug effects
MH  - Animals
MH  - Aurovertins/*toxicity
MH  - Body Temperature/drug effects
MH  - Body Weight/drug effects
MH  - Cardiovascular System/drug effects
MH  - Electroencephalography
MH  - Female
MH  - In Vitro Techniques
MH  - Kidney/drug effects
MH  - Lethal Dose 50
MH  - Liver/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Motor Activity/drug effects
MH  - Mycotoxins/*toxicity
MH  - Myocardial Contraction/drug effects
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Pyrans/*toxicity
MH  - Rabbits
MH  - Rana pipiens
MH  - Reaction Time/drug effects
MH  - Respiration/drug effects
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Res Commun Chem Pathol Pharmacol. 1988 Jan;59(1):31-52.