PMID- 3258745
OWN - NLM
STAT- MEDLINE
DCOM- 19880524
LR  - 20190612
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 152
IP  - 1
DP  - 1988 Apr 15
TI  - Transforming growth factor alpha (TGF alpha) induction of C-FOS and C-MYC 
      expression in C3H 10T1/2 cells.
PG  - 216-22
AB  - We have investigated the effects of transforming growth factor alpha (TGF alpha) 
      in C3H10T1/2 cells, on S phase entry and early gene activation events associated 
      with cell cycle progression. We find that EGF and TGF alpha, which both utilize 
      the EGF receptor for signal generation, are able to stimulate DNA synthesis in 
      these cells with nearly superimposable kinetics; however, the stimulation by TGF 
      alpha was slightly greater at nearly all time points assayed. This report is the 
      first showing that TGF alpha, like EGF, vigorously induces c-myc and c-fos gene 
      expression in these cells. A significant stimulation of c-myc and c-fos mRNA 
      levels is observed with both TGF alpha and EGF; c-myc mRNA levels show an 8-fold 
      induction with both mitogens, while c-fos inductions were on the order of 12 to 
      14-fold at maximum. However, the induction of c-myc mRNA by TGF alpha has slower 
      kinetics than by EGF.
FAU - Cutry, A F
AU  - Cutry AF
AD  - Department of Experimental Biology, Roswell Park Memorial Institute, Buffalo, NY 
      14263.
FAU - Kinniburgh, A J
AU  - Kinniburgh AJ
FAU - Twardzik, D R
AU  - Twardzik DR
FAU - Wenner, C E
AU  - Wenner CE
LA  - eng
GR  - 2 S07 RR05648 21/RR/NCRR NIH HHS/United States
GR  - CA43661/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Growth Substances)
RN  - 0 (Peptides)
RN  - 62229-50-9 (Epidermal Growth Factor)
RN  - 76057-06-2 (Transforming Growth Factors)
SB  - IM
MH  - Animals
MH  - Cells, Cultured
MH  - DNA Replication/drug effects
MH  - Epidermal Growth Factor/pharmacology
MH  - Growth Substances/*pharmacology
MH  - Kinetics
MH  - Mice
MH  - Peptides/*pharmacology
MH  - Proto-Oncogenes/*drug effects
MH  - Transcription, Genetic/*drug effects
MH  - Transforming Growth Factors
EDAT- 1988/04/15 00:00
MHDA- 1988/04/15 00:01
CRDT- 1988/04/15 00:00
PHST- 1988/04/15 00:00 [pubmed]
PHST- 1988/04/15 00:01 [medline]
PHST- 1988/04/15 00:00 [entrez]
AID - S0006-291X(88)80702-2 [pii]
AID - 10.1016/s0006-291x(88)80702-2 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 1988 Apr 15;152(1):216-22. doi: 
      10.1016/s0006-291x(88)80702-2.