PMID- 3258782
OWN - NLM
STAT- MEDLINE
DCOM- 19880609
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 441
IP  - 1-2
DP  - 1988 Feb 16
TI  - Evidence for the involvement of corticotropin-releasing factor in the 
      gastrointestinal disturbances induced by acoustic and cold stress in mice.
PG  - 1-4
AB  - The influence of acoustic (AS) and cold (CS) stress on gastric emptying and 
      intestinal transit were evaluated in mice using a radiolabelled 51chromium test 
      meal. AS was produced by playing music through loudspeakers (less than 86 dB) in 
      a confined box at room temperature (20 degrees C) and CS was obtained by exposure 
      to 10 degrees C. Twenty minutes exposure to AS or CS caused a significant (P less 
      than 0.05) increase in gastric emptying in mice. Intracerebroventricular (i.c.v.) 
      administration of 150 ng of rat corticotropin-releasing factor (rCRF), 30 min 
      before the test meal, also increased gastric emptying but neither intraperitoneal 
      (i.p.) administration of rCRF at the same dosage nor corticosterone (300 ng) and 
      ACTH (375 microU) were able to induce significant changes in gastric emptying. 
      The increase in gastric emptying induced by AS and CS and by i.c.v. injection of 
      rCRF were blocked by previous i.p. administration of an antiserum against rCRF. 
      These findings strongly support the hypothesis that alterations in gastric 
      emptying induced by AS and CS in mice are due to the release of CRF acting 
      directly on central structures involved in the control of gastrointestinal 
      motility.
FAU - Bueno, L
AU  - Bueno L
AD  - Department of Pharmacology and Toxicology INRA, Toulouse, France.
FAU - Gue, M
AU  - Gue M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Cerebral Ventricles/drug effects/*physiology/physiopathology
MH  - Cold Temperature
MH  - Corticotropin-Releasing Hormone/administration & dosage/*pharmacology
MH  - Gastric Emptying/*drug effects
MH  - Gastrointestinal Motility/drug effects
MH  - Gastrointestinal Transit/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Noise
MH  - Stress, Physiological/*physiopathology
EDAT- 1988/02/16 00:00
MHDA- 1988/02/16 00:01
CRDT- 1988/02/16 00:00
PHST- 1988/02/16 00:00 [pubmed]
PHST- 1988/02/16 00:01 [medline]
PHST- 1988/02/16 00:00 [entrez]
AID - 0006-8993(88)91376-5 [pii]
AID - 10.1016/0006-8993(88)91376-5 [doi]
PST - ppublish
SO  - Brain Res. 1988 Feb 16;441(1-2):1-4. doi: 10.1016/0006-8993(88)91376-5.