PMID- 32587931
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220415
IS  - 2456-8007 (Electronic)
IS  - 2456-8007 (Linking)
VI  - 5
IP  - 1
DP  - 2020
TI  - Obstructive Sleep Apnea Risk and Stroke among Blacks with Metabolic Syndrome: 
      Results from Metabolic Syndrome Outcome (MetSO) Registry.
LID - 143 [pii]
LID - 10.15344/2456-8007/2020/143 [doi]
AB  - INTRODUCTION: The American Stroke Association estimates that stroke is the fifth 
      leading cause of death in the United States. According to the Center for Disease 
      Control and Prevention someone in the United States has a stoke every 40 seconds, 
      affecting more than 795,000 people of which 140,000 result in death [1]. Emerging 
      evidence suggests that obstructive sleep apnea (OSA) is a strong risk factor for 
      stroke. This study using The Metabolic Syndrome Outcome (MetSO) registry explored 
      whether blacks at risk for obstructive sleep apnea (OSA) are at greater risk for 
      a stroke. METHOD: The present study utilized data from the MetSO study, an 
      NIH-funded cohort study of blacks with metabolic syndrome (MetS). Patients were 
      diagnosed with MetS using standard criteria articulated in the joint interim 
      statement for harmonizing the MetS. The study assessed OSA risk using the Apnea 
      Risk Evaluation System (ARES); defining high risk as a total ARES score >/=6. Data 
      was coded and analyzed by an experienced statistician using SPSS 20.0. RESULTS: A 
      total of 1035 participants were screened for MetS in the MetSO registry. During 
      the data collection period 875 participants were enrolled during the time of 
      analysis. The average age of the sample was 62+/-14 years (range: 20-97); 71% were 
      female, and all were of black race/ethnicity. Seventy-one percent reported 
      finishing high school, and 43% reported annual income <10K. Descriptive analyses 
      showed 93% of the participants were diagnosed with hypertension; 61%, diabetes; 
      72%, dyslipidemia; 90% were overweight/obese; 33% had a history of heart disease 
      and 10% had a stroke history. Using the ARES screener, we estimated that 48% were 
      at high risk for OSA. Logistic regression analysis, adjusting for age and gender, 
      showed that patients at high risk for OSA had a nearly three-fold increase in the 
      odds of having a stroke (OR = 2.79, 95% CI: 1.64-4.73). CONCLUSION: In the MetSO 
      registry, a cohort of blacks with MetS, the prevalence of stroke is greater than 
      in the general US population. Blacks at risk for OSA are particularly vulnerable 
      to experiencing a stroke.
FAU - Rogers, April J
AU  - Rogers AJ
AD  - St. John's University, Division of Health and Human Services, College of 
      Professional Studies, Queens, New York, USA.
FAU - Kaplan, Ian
AU  - Kaplan I
AD  - SUNY Down State Medical, Department of Internal Medicine Center Brooklyn, New 
      York, USA.
FAU - Chung, Alicia
AU  - Chung A
AD  - Center for Healthful Behavior Change (CHBC), Department of Population Health, NYU 
      Grossman School of Medicine, New York, NY, USA.
FAU - McFarlane, Samy I
AU  - McFarlane SI
AD  - SUNY Down State Medical, Department of Internal Medicine Center Brooklyn, New 
      York, USA.
FAU - Jean-Louis, Girardin
AU  - Jean-Louis G
AD  - Center for Healthful Behavior Change (CHBC), Department of Population Health, NYU 
      Grossman School of Medicine, New York, NY, USA.
LA  - eng
GR  - R01 HL095799/HL/NHLBI NIH HHS/United States
GR  - R01 MD004113/MD/NIMHD NIH HHS/United States
GR  - R25 HL105444/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20200226
PL  - India
TA  - Int J Clin Res Trials
JT  - International journal of clinical research & trials
JID - 101737788
PMC - PMC7316191
MID - NIHMS1592646
OTO - NOTNLM
OT  - Blacks
OT  - MetSO
OT  - Metabolic Syndrome
OT  - Obesity
OT  - Obstructive Sleep Apnea
OT  - Risk factor
OT  - Stroke
COIS- Competing Interests The authors have read the journal's policy and have the 
      following potential conflicts: All authors declare that they have no proprietary, 
      financial, professional, nor any other personal interest of any nature or kind in 
      any product or services and/or company that could be construed or considered to 
      be a potential conflict of interest that might have influenced the views 
      expressed in this manuscript.
EDAT- 2020/06/27 06:00
MHDA- 2020/06/27 06:01
PMCR- 2020/06/25
CRDT- 2020/06/27 06:00
PHST- 2020/06/27 06:00 [entrez]
PHST- 2020/06/27 06:00 [pubmed]
PHST- 2020/06/27 06:01 [medline]
PHST- 2020/06/25 00:00 [pmc-release]
AID - 143 [pii]
AID - 10.15344/2456-8007/2020/143 [doi]
PST - ppublish
SO  - Int J Clin Res Trials. 2020;5(1):143. doi: 10.15344/2456-8007/2020/143. Epub 2020 
      Feb 26.