PMID- 32588382
OWN - NLM
STAT- MEDLINE
DCOM- 20211011
LR  - 20221207
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 44
IP  - 3
DP  - 2021 Mar
TI  - Association between lower plasma adiponectin levels and higher plasma thrombin 
      generation parameters in men with type 2 diabetes: role of plasma triglycerides.
PG  - 547-555
LID - 10.1007/s40618-020-01340-3 [doi]
AB  - OBJECTIVE: Previous studies showed a significant association between lower plasma 
      adiponectin levels and higher risk of adverse cardiovascular outcomes in patients 
      with and without type 2 diabetes mellitus (T2DM). Presently, it is uncertain 
      whether lower plasma adiponectin levels are associated with greater plasma 
      thrombin generation in patients with T2DM. PATIENTS AND METHODS: We studied 82 
      middle-aged men with non-insulin-treated T2DM [mean age +/- SD: 64.1 +/- 8 years; 
      median duration of diabetes: 12.5 (inter-quartile range 6-19) years; mean 
      hemoglobin A1c 7.0 +/- 0.7%], consecutively attending our diabetes outpatient 
      service over a 6-month period. Using the newly developed fully automated thrombin 
      generation analyzer ST Genesia(R), we measured the plasma parameters lag time (LT), 
      time to peak (TP), peak height (PH) and endogenous thrombin potential (ETP) in 
      all participants. RESULTS: In univariable linear regression analyses, lower 
      plasma adiponectin levels were significantly associated with higher plasma 
      thrombin generation parameters, as reflected by higher values of PH (Pearson's r 
      coefficient = - 0.228, p = 0.039) and EPT (r = - 0.293, p = 0.007). Plasma 
      adiponectin levels were not significantly associated with other thrombin 
      generation parameters (LT and TP). Notably, the significant associations of 
      plasma adiponectin levels with thrombin PH and EPT values persisted after 
      adjustment for age and adiposity measures, but they were lost after additional 
      adjustment for plasma triglycerides. CONCLUSION: Our findings show for the first 
      time the existence of a significant association between lower levels of plasma 
      adiponectin and greater plasma thrombin generation (as assessed by the ST 
      Genesia(R) analyzer) in men with non-insulin-treated T2DM, which appears to be 
      largely mediated by plasma triglycerides.
FAU - Mantovani, A
AU  - Mantovani A
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy. alessandro.mantovani@univr.it.
FAU - Danese, E
AU  - Danese E
AD  - Section of Clinical Biochemistry, Department of Medicine, University and Azienda 
      Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
FAU - Salvagno, G L
AU  - Salvagno GL
AD  - Section of Clinical Biochemistry, Department of Medicine, University and Azienda 
      Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
FAU - Gelati, M
AU  - Gelati M
AD  - Section of Clinical Biochemistry, Department of Medicine, University and Azienda 
      Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
FAU - Turino, T
AU  - Turino T
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy.
FAU - Bovo, C
AU  - Bovo C
AD  - Medical Direction, University and Azienda Ospedaliera Universitaria Integrata of 
      Verona, Verona, Italy.
FAU - Lippi, G
AU  - Lippi G
AD  - Section of Clinical Biochemistry, Department of Medicine, University and Azienda 
      Ospedaliera Universitaria Integrata of Verona, Verona, Italy.
FAU - Targher, G
AU  - Targher G
AD  - Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, 
      University and Azienda Ospedaliera Universitaria Integrata of Verona, Piazzale 
      Stefani, 1, 37126, Verona, Italy.
LA  - eng
PT  - Journal Article
DEP - 20200625
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Triglycerides)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Adiponectin/*blood
MH  - Aged
MH  - Biomarkers/*blood
MH  - Blood Glucose/analysis
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*pathology
MH  - Follow-Up Studies
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Prospective Studies
MH  - Thrombin/*analysis
MH  - Triglycerides/*blood
OTO - NOTNLM
OT  - Adiponectin
OT  - Plasma thrombin generation
OT  - Triglycerides
OT  - Type 2 diabetes
EDAT- 2020/06/27 06:00
MHDA- 2021/10/12 06:00
CRDT- 2020/06/27 06:00
PHST- 2020/05/14 00:00 [received]
PHST- 2020/06/19 00:00 [accepted]
PHST- 2020/06/27 06:00 [pubmed]
PHST- 2021/10/12 06:00 [medline]
PHST- 2020/06/27 06:00 [entrez]
AID - 10.1007/s40618-020-01340-3 [pii]
AID - 10.1007/s40618-020-01340-3 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2021 Mar;44(3):547-555. doi: 10.1007/s40618-020-01340-3. 
      Epub 2020 Jun 25.