PMID- 32589128
OWN - NLM
STAT- MEDLINE
DCOM- 20211026
LR  - 20211026
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 39
IP  - 6
DP  - 2020 Nov/Dec
TI  - MYB-QKI rearrangement in angiocentric glioma.
PG  - 263-270
LID - 10.5414/NP301284 [doi]
AB  - AIMS: To evaluate the occurrence and diagnostic value of MYB-QKI rearrangement 
      status in angiocentric glioma (AG) in Chinese patients. MATERIALS AND METHODS: 27 
      cases were collected from six hospitals, followed by a retrospective analysis of 
      clinical, radiological, and morphological data. MYB protein expression was 
      assessed by immunohistochemical staining (IHC), and the MYB-QKI rearrangement was 
      detected by fluorescence in situ hybridization (FISH). RESULTS: Among the 27 
      cases (16 males), the median age at surgery was 17 years (range 3 - 43 years); 24 
      (88.9%) cases had a history of refractory epilepsy, and the mean history of 
      pre-surgical epilepsy was 13 years (range 1.5 - 27 years); 26 (96.3%) cases had 
      lesions located in the superficial cerebrocortical regions, and 1 (3.7%) case had 
      a lesion in the brainstem. Except for the classic histological features, the 
      involvement of superficial cortex extending to the leptomeninges, 
      microcalcification, and cystic pattern with microcystic formations was observed 
      in 11 (40.7%), 3 (11.1%), and 4 (14.8%) cases, respectively. IHC showed that all 
      27 cases were positive for glial fibrillary acidic protein (GFAP) and vimentin, 
      and negative for neuronal nuclear antigen (NeuN). The positive rates of 
      epithelial membrane antigen (EMA) and D2-40 were 81.5% (22/27) and 74.1% (20/27), 
      respectively. A total of 14 (51.9%) cases were positive for MYB. The rate of 
      Ki-67 proliferation was 1 - 5% in 25 cases, and in 2 cases with anaplastic 
      features it was 10 and 20%. MYB-QKI rearrangement was revealed by FISH 
      examination in 95.8% (23/24) of the AGs, including 3 cases with atypical 
      histological appearance. CONCLUSION: Compared to IHC, FISH was more appropriate 
      for detecting MYB-QKI rearrangement. MYB-QKI rearrangement was detected in the 
      majority of Chinese AG cases, and therefore represents a potential diagnostic 
      biomarker for AG.
FAU - Lian, Fang
AU  - Lian F
FAU - Wang, Lei-Ming
AU  - Wang LM
FAU - Qi, Xue-Ling
AU  - Qi XL
FAU - Liu, Li-Na
AU  - Liu LN
FAU - Wang, Xing-Fu
AU  - Wang XF
FAU - Fu, Jing
AU  - Fu J
FAU - Xiong, Ji
AU  - Xiong J
FAU - Lu, De-Hong
AU  - Lu DH
FAU - Piao, Yue-Shan
AU  - Piao YS
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (MYB protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myb)
RN  - 0 (QKI protein, human)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Adenoid Cystic/metabolism/pathology
MH  - Child
MH  - Child, Preschool
MH  - Epilepsy/diagnosis/metabolism/pathology
MH  - Female
MH  - Glial Fibrillary Acidic Protein/metabolism
MH  - Glioma/*metabolism/*pathology
MH  - Humans
MH  - Male
MH  - Proto-Oncogene Proteins c-myb/*metabolism
MH  - RNA-Binding Proteins/genetics/*metabolism
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2020/06/27 06:00
MHDA- 2021/10/27 06:00
CRDT- 2020/06/27 06:00
PHST- 2020/10/22 00:00 [accepted]
PHST- 2020/06/27 06:00 [pubmed]
PHST- 2021/10/27 06:00 [medline]
PHST- 2020/06/27 06:00 [entrez]
AID - 186814 [pii]
AID - 10.5414/NP301284 [doi]
PST - ppublish
SO  - Clin Neuropathol. 2020 Nov/Dec;39(6):263-270. doi: 10.5414/NP301284.