PMID- 32589715
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1460-2431 (Electronic)
IS  - 0022-0957 (Linking)
VI  - 71
IP  - 19
DP  - 2020 Oct 7
TI  - Human-like telomeres in Zostera marina reveal a mode of transition from the plant 
      to the human telomeric sequences.
PG  - 5786-5793
LID - 10.1093/jxb/eraa293 [doi]
AB  - A previous study describing the genome of Zostera marina, the most widespread 
      seagrass in the Northern hemisphere, revealed some genomic signatures of 
      adaptation to the aquatic environment such as the loss of stomatal genes, while 
      other functions such as an algal-like cell wall composition were acquired. Beyond 
      these, the genome structure and organization were comparable with those of the 
      majority of plant genomes sequenced, except for one striking feature that went 
      unnoticed at that time: the presence of human-like instead of the expected 
      plant-type telomeric sequences. By using different experimental approaches 
      including fluorescence in situ hybridization (FISH), genome skimming by 
      next-generation sequencing (NGS), and analysis of non-coding transcriptome, we 
      have confirmed its telomeric location in the chromosomes of Z. marina. We have 
      also identified its telomerase RNA (TR) subunit, confirming the presence of the 
      human-type telomeric sequence in the template region. Remarkably, this region was 
      found to be very variable even in clades with a highly conserved telomeric 
      sequence across their species. Based on this observation, we propose that 
      alternative annealing preferences in the template borders can explain the 
      transition between the plant and human telomeric sequences. The further 
      identification of paralogues of TR in several plant genomes led us to the 
      hypothesis that plants may retain an increased ability to change their telomeric 
      sequence. We discuss the implications of this occurrence in the evolution of 
      telomeres while introducing a mechanistic model for the transition from the plant 
      to the human telomeric sequences.
CI  - (c) The Author(s) 2020. Published by Oxford University Press on behalf of the 
      Society for Experimental Biology. All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Peska, Vratislav
AU  - Peska V
AD  - Department of Cell Biology and Radiobiology, Institute of Biophysics of the Czech 
      Academy of Sciences, Brno, Czech Republic.
FAU - Matl, Martin
AU  - Matl M
AD  - Mendel Centre for Plant Genomics and Proteomics, CEITEC, Masaryk University, 
      Brno, Czech Republic.
FAU - Mandakova, Terezie
AU  - Mandakova T
AD  - Mendel Centre for Plant Genomics and Proteomics, CEITEC, Masaryk University, 
      Brno, Czech Republic.
AD  - Laboratory of Plant Molecular Genetics, Department of Experimental Biology, 
      Faculty of Science, Masaryk University, Brno, Czech Republic.
FAU - Vitales, Daniel
AU  - Vitales D
AD  - Institut Botanic de Barcelona (IBB, CSIC-Ajuntament de Barcelona), Passeig del 
      Migdia s/n, Barcelona, Catalonia, Spain.
FAU - Fajkus, Petr
AU  - Fajkus P
AD  - Department of Cell Biology and Radiobiology, Institute of Biophysics of the Czech 
      Academy of Sciences, Brno, Czech Republic.
AD  - Mendel Centre for Plant Genomics and Proteomics, CEITEC, Masaryk University, 
      Brno, Czech Republic.
FAU - Fajkus, Jiri
AU  - Fajkus J
AD  - Department of Cell Biology and Radiobiology, Institute of Biophysics of the Czech 
      Academy of Sciences, Brno, Czech Republic.
AD  - Mendel Centre for Plant Genomics and Proteomics, CEITEC, Masaryk University, 
      Brno, Czech Republic.
AD  - Laboratory of Functional Genomics and Proteomics, NCBR, Faculty of Science, 
      Masaryk University, Brno, Czech Republic.
FAU - Garcia, Sonia
AU  - Garcia S
AD  - Institut Botanic de Barcelona (IBB, CSIC-Ajuntament de Barcelona), Passeig del 
      Migdia s/n, Barcelona, Catalonia, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Exp Bot
JT  - Journal of experimental botany
JID - 9882906
SB  - IM
MH  - Base Sequence
MH  - Genome, Plant
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Telomere/genetics
MH  - *Zosteraceae
OTO - NOTNLM
OT  - Animal telomeres
OT  - Tandem Repeats Finder
OT  - chromosome
OT  - cytogenetics
OT  - plant telomeres
OT  - telomerase RNA
OT  - telomere template
EDAT- 2020/06/27 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/06/27 06:00
PHST- 2020/04/01 00:00 [received]
PHST- 2020/06/16 00:00 [accepted]
PHST- 2020/06/27 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/06/27 06:00 [entrez]
AID - 5863406 [pii]
AID - 10.1093/jxb/eraa293 [doi]
PST - ppublish
SO  - J Exp Bot. 2020 Oct 7;71(19):5786-5793. doi: 10.1093/jxb/eraa293.