PMID- 32589879
OWN - NLM
STAT- MEDLINE
DCOM- 20201006
LR  - 20220824
IS  - 1678-4391 (Electronic)
IS  - 1413-8670 (Print)
IS  - 1413-8670 (Linking)
VI  - 24
IP  - 4
DP  - 2020 Jul-Aug
TI  - Association between NDO-LID and PGL-1 for leprosy and class I and II human 
      leukocyte antigen alleles in an indigenous community in Southwest Amazon.
PG  - 296-303
LID - S1413-8670(20)30079-9 [pii]
LID - 10.1016/j.bjid.2020.05.009 [doi]
AB  - The frequencies of the Human leukocyte antigen (HLA) alleles in the Puyanawa 
      indigenous reserve population and their association with the NDO-LID and ELISA 
      PGL-1 rapid serological test was assessed. This was a cross-sectional study with 
      an epidemiological clinical design conducted in two indigenous communities in the 
      state of Acre, Brazil. Blood was collected in a tube with EDTA to identify HLA 
      alleles and perform serological tests. DNA was obtained using the salting out 
      procedure. The LabType technique (One-Lambda-USA) was used for HLA class I (loci 
      A*, B* and C*) and II (loci DRB1*, DQA1* and DQB1*) typing. Allele frequency was 
      obtained by direct count, and the chi-square test was used to assess the 
      association with the NDO-LID and PGL-1 tests. The most frequent alleles in the 
      two communities were: HLA-A*02:01, HLA-B*40:02, HLA-DRB1*16:02, HLA-DQA1*05:05 
      and HLA-DQB1*03:01. The allele HLA-C*04:01 was the most common in the Barao 
      community, and the allele HLA-C*07:01 in Ipiranga. Among individuals who 
      presented seropositivity to the NDO-LID test, the association with alleles 
      HLA-A*02 (43.18% vs 24.8%, p=0.03, OR=2.35) and HLA-B*53 (6.83% vs 0.0%, p=0.03, 
      OR=8.95) was observed in the Barao community. HLA-B*15 was associated with 
      non-seroconversion to the NDO-LID test in Ipiranga. In both communities, HLA-B*40 
      and HLA-C*03 were associated with positive serological response to ELISA PGL-1. 
      The HLA class I and II alleles most frequently found in this study have already 
      been described among Terena indigenous groups, and HLA class I contributes to 
      seroconversion to NDO-LID and PGL-1 tests in inhabitants of the Barao and 
      Ipiranga communities.
CI  - Copyright (c) 2020 Sociedade Brasileira de Infectologia. Published by Elsevier 
      Espana, S.L.U. All rights reserved.
FAU - Teles, Stefanie Ferreira
AU  - Teles SF
AD  - Universidade Federal do Acre, Centro Multidisciplinar, Cruzeiro do Sul, AC, 
      Brazil. Electronic address: stefanieftm@hotmail.com.
FAU - Silva, Eliane Aparecida
AU  - Silva EA
AD  - Instituto Lauro de Souza Lima, Bauru/SP, Laboratorio de Imunologia, Bauru, SP, 
      Brazil.
FAU - Souza, Rodrigo Medeiros de
AU  - Souza RM
AD  - Universidade Federal do Acre, Centro Multidisciplinar, Laboratorio de Imunologia 
      e Microbiologia, Cruzeiro do Sul, AC, Brazil.
FAU - Tomimori, Jane
AU  - Tomimori J
AD  - Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Departamento de 
      Dermatologia, Sao Paulo, SP, Brazil.
FAU - Florian, Marcos Cesar
AU  - Florian MC
AD  - Universidade Federal de Sao Paulo, Escola Paulista de Medicina, Departamento de 
      Dermatologia, Sao Paulo, SP, Brazil.
FAU - Souza, Rogerio Oliveira
AU  - Souza RO
AD  - Universidade Federal do Acre, Centro Multidisciplinar, Cruzeiro do Sul, AC, 
      Brazil.
FAU - Marcos, Elaine Valim Camarinha
AU  - Marcos EVC
AD  - Instituto Lauro de Souza Lima, Bauru/SP, Laboratorio de Imunogenetica, Bauru, SP, 
      Brazil.
FAU - Souza-Santana, Fabiana Covolo de
AU  - Souza-Santana FC
AD  - Instituto Lauro de Souza Lima, Bauru/SP, Laboratorio de Imunogenetica, Bauru, SP, 
      Brazil.
FAU - Gamba, Monica Antar
AU  - Gamba MA
AD  - Universidade Federal de Sao Paulo, Escola Paulista de Enfermagem, Departamento de 
      Saude Coletiva, Sao Paulo, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20200624
PL  - Brazil
TA  - Braz J Infect Dis
JT  - The Brazilian journal of infectious diseases : an official publication of the 
      Brazilian Society of Infectious Diseases
JID - 9812937
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Brazil
MH  - Cross-Sectional Studies
MH  - Gene Frequency
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - *Leprosy
PMC - PMC9392080
OTO - NOTNLM
OT  - Class I MHC genes
OT  - Class II MHC genes
OT  - HLA
OT  - Leprosy
OT  - Nursing
OT  - South American indigenous populations
EDAT- 2020/06/27 06:00
MHDA- 2020/10/07 06:00
PMCR- 2020/06/24
CRDT- 2020/06/27 06:00
PHST- 2020/02/07 00:00 [received]
PHST- 2020/05/11 00:00 [revised]
PHST- 2020/05/31 00:00 [accepted]
PHST- 2020/06/27 06:00 [pubmed]
PHST- 2020/10/07 06:00 [medline]
PHST- 2020/06/27 06:00 [entrez]
PHST- 2020/06/24 00:00 [pmc-release]
AID - S1413-8670(20)30079-9 [pii]
AID - 10.1016/j.bjid.2020.05.009 [doi]
PST - ppublish
SO  - Braz J Infect Dis. 2020 Jul-Aug;24(4):296-303. doi: 10.1016/j.bjid.2020.05.009. 
      Epub 2020 Jun 24.